Associations, Outcomes and Genomics of GB Virus C, Hepatitis C Virus and Human Immunodeficiency Virus Infection

NCT00164060 | Terminated

• 1 other identifier: 35/04
• Study Type: observational
• Target: 158
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the effect of GB virus C (GBV-C) on the natural history of chronic hepatitis C virus (HCV) infection in subjects co-infected with HIV and HCV. The other aspect of the study is to assess the effect of GBV-C on the severity of liver disease due to chronic hepatitis C in subjects co-infected with HIV and HCV. This will be done by determining the point prevalence of co-infection retrospectively then following that cohort prospectively. In addition, further individuals will be recruited in a prospective manner.

Conditions

Hepatitis C; HIV Infections

Keywords

HCV; HIV co-infection

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sera available and appropriate for testing, including serial sera over a period of time (retrospective analysis)
• HIV serology positive.
• Unequivocal HCV antibody positive or HCV RNA positive.

You may not qualify if:

• Those without sera available.
• Those unwilling to give informed consent.
• Persons with hepatitis B virus infection, as defined by the presence of hepatitis B surface antigen and/or hepatitis B virus DNA positive.

Sponsors & Collaborators

• Bayside Health: lead

Study Sites (1)

Alfred Hospital

Melbourne, Victoria, 3181, Australia

Location

Related Publications (2)

• Berzsenyi MD, Bowden DS, Roberts SK. GB virus C: insights into co-infection. J Clin Virol. 2005 Aug;33(4):257-66. doi: 10.1016/j.jcv.2005.04.002.

  PMID: 15922655 RESULT

• Berzsenyi MD, Bowden DS, Kelly HA, Watson KM, Mijch AM, Hammond RA, Crowe SM, Roberts SK. Reduction in hepatitis C-related liver disease associated with GB virus C in human immunodeficiency virus coinfection. Gastroenterology. 2007 Dec;133(6):1821-30. doi: 10.1053/j.gastro.2007.08.076. Epub 2007 Sep 5.

  PMID: 18054555 DERIVED

MeSH Terms

Conditions

Hepatitis C; HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Hepatitis, Viral, Human; Virus Diseases; Flaviviridae Infections; RNA Virus Infections; Hepatitis; Liver Diseases; Digestive System Diseases; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Mark D Berzsenyi, MBBS

  Alfred Hospital/Bayside Health

  PRINCIPAL INVESTIGATOR

• Stuart R Roberts, MBBS

  Alfred Hospital/Bayside Health

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: September 13, 2005
• First Posted: September 14, 2005
• Study Start: February 1, 2004
• Primary Completion: May 1, 2007
• Study Completion: May 1, 2007
• Last Updated: December 5, 2013

Record last verified: 2005-09

Locations

AU (1)