Prevalence of Hepatitis C Virus Infection in HIV-Infected Children
Hepatitis C Prevalence in Perinatally Infected HIV-Positive Children Enrolled in PACTG 219C
2 other identifiers
observational
600
2 countries
39
Brief Summary
The purpose of this study is to find out how many children who are infected with HIV are also infected with hepatitis C virus (HCV). HCV infection is a major health concern. HIV-infected adults who are co-infected with HCV appear to have more rapid HIV disease progression. There is little data on how widespread HCV is among children who are HIV-infected. Information from this study will help determine the need for future HCV studies. This study also will obtain blood samples for future testing for other hepatitis viruses such as hepatitis G virus (HGV or GB virus C).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
39 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 14, 2002
CompletedFirst Posted
Study publicly available on registry
May 15, 2002
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2003
CompletedOctober 31, 2012
October 1, 2012
May 14, 2002
October 30, 2012
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- Patients may be eligible for this substudy if they:
- Are between 1 year and 20 years of age.
- Were infected with HIV from the mother at or around the time of birth.
- Are enrolled in PACTG 219C.
- Children known to be HCV-infected will be permitted to enter the substudy.
You may not qualify if:
- Patients may not be eligible for this substudy if they:
- Have hemophilia.
- Contracted HIV through a route other than from the mother around the time of birth.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (39)
Univ of Alabama at Birmingham - Pediatric
Birmingham, Alabama, 35233, United States
Phoenix Childrens Hosp
Phoenix, Arizona, 85006, United States
Los Angeles County - USC Med Ctr
Los Angeles, California, 90033, United States
Children's Hosp of Oakland
Oakland, California, 94609-1809, United States
Univ of California, San Diego
San Diego, California, 92103, United States
UCSF, Moffitt Hospital (Pediatric)
San Francisco, California, 94143, United States
Children's Hosp of Denver
Denver, Colorado, 802181088, United States
Connecticut Childrens Med Ctr (Pediatric)
Farmington, Connecticut, 06030, United States
Yale Univ Med School
New Haven, Connecticut, 06504, United States
Howard Univ Hosp
Washington D.C., District of Columbia, 20060, United States
Univ of Miami (Pediatric)
Miami, Florida, 33161, United States
Med College of Georgia
Augusta, Georgia, 30912, United States
The Med Ctr Inc
Columbus, Georgia, 31901, United States
Mt Sinai Hosp Med Ctr / Dept of Pediatrics
Chicago, Illinois, 60608, United States
The Univ of Chicago Children's Hosp
Chicago, Illinois, 60612, United States
University of Illinois
Chicago, Illinois, 60612, United States
Tulane Univ / Charity Hosp of New Orleans
New Orleans, Louisiana, 701122699, United States
Univ of Maryland at Baltimore / Univ Med Ctr
Baltimore, Maryland, 21201, United States
Johns Hopkins Hosp - Pediatric
Baltimore, Maryland, 21287-4933, United States
Baystate Med Ctr of Springfield
Springfield, Massachusetts, 01199, United States
Univ of Massachusetts Med School
Worcester, Massachusetts, 016550001, United States
Children's Hosp of Michigan
Detroit, Michigan, 48201, United States
Univ of Medicine & Dentistry of New Jersey / Univ Hosp
Newark, New Jersey, 071032714, United States
Children's Hospital at SUNY Downstate
Brooklyn, New York, 11203, United States
Mount Sinai Med Ctr
New York, New York, 10029, United States
Columbia Presbyterian Med Ctr
New York, New York, 10032, United States
Univ of Rochester Med Ctr
Rochester, New York, 146420001, United States
State Univ of New York at Stony Brook
Stony Brook, New York, 117948111, United States
SUNY Health Sciences Ctr at Syracuse / Pediatrics
Syracuse, New York, 13210, United States
Univ of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Duke University (Pediatric)
Durham, North Carolina, 27705, United States
Childrens Hosp of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
St. Christopher's Hosp for Children, Philadelphia
Philadelphia, Pennsylvania, 19134, United States
Saint Jude Children's Research Hosp of Memphis
Memphis, Tennessee, 381052794, United States
Vanderbilt Univ Med Ctr
Nashville, Tennessee, 372322581, United States
Children's Med Ctr of Dallas
Dallas, Texas, 75235, United States
Texas Children's Hosp / Baylor Univ
Houston, Texas, 77030, United States
Univ. of Puerto Rico, U. Children's Hospital AIDS
San Juan, 00936-5067, Puerto Rico
San Juan City Hosp
San Juan, 009367344, Puerto Rico
Related Publications (5)
Tajiri H, Miyoshi Y, Funada S, Etani Y, Abe J, Onodera T, Goto M, Funato M, Ida S, Noda C, Nakayama M, Okada S. Prospective study of mother-to-infant transmission of hepatitis C virus. Pediatr Infect Dis J. 2001 Jan;20(1):10-4. doi: 10.1097/00006454-200101000-00003.
PMID: 11176560BACKGROUNDTillmann HL, Heiken H, Knapik-Botor A, Heringlake S, Ockenga J, Wilber JC, Goergen B, Detmer J, McMorrow M, Stoll M, Schmidt RE, Manns MP. Infection with GB virus C and reduced mortality among HIV-infected patients. N Engl J Med. 2001 Sep 6;345(10):715-24. doi: 10.1056/NEJMoa010398.
PMID: 11547740BACKGROUNDXiang J, Wunschmann S, Diekema DJ, Klinzman D, Patrick KD, George SL, Stapleton JT. Effect of coinfection with GB virus C on survival among patients with HIV infection. N Engl J Med. 2001 Sep 6;345(10):707-14. doi: 10.1056/NEJMoa003364.
PMID: 11547739BACKGROUNDThomas SL, Newell ML, Peckham CS, Ades AE, Hall AJ. A review of hepatitis C virus (HCV) vertical transmission: risks of transmission to infants born to mothers with and without HCV viraemia or human immunodeficiency virus infection. Int J Epidemiol. 1998 Feb;27(1):108-17. doi: 10.1093/ije/27.1.108.
PMID: 9563703BACKGROUNDPapaevangelou V, Pollack H, Rochford G, Kokka R, Hou Z, Chernoff D, Hanna B, Krasinski K, Borkowsky W. Increased transmission of vertical hepatitis C virus (HCV) infection to human immunodeficiency virus (HIV)-infected infants of HIV- and HCV-coinfected women. J Infect Dis. 1998 Oct;178(4):1047-52. doi: 10.1086/515668.
PMID: 9806033BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Susan Schuval