Nitric Oxide, Endothelin-1, and the Patency of Ductus Arteriosus in Preterm Infants

NCT00162903 | Completed

• 1 other identifier: 26955
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

BACKGROUND Patent ductus arteriosus (PDA) is a frequent clinical event in preterm infant. The cardiopulmonary functions of these preterm babies may be adversely affected by the patency of ductus arteriosus. Ductal tissues are sensitive to the constricting effect of endothelin-1 and the dilating effect of prostaglandins, inflammatory mediators, and concentration of oxygen. OBJECTIVE To examine the role of endogenous nitric oxide (NO) and endothelin-1 (ET-1) in the pathogenesis of patent ductus arteriosus of the preterm infants. We hypothesize that the patency of ductus arterious in preterm infants is probably due to inappropriate production of endogenous nitric oxide and the interaction with various inflammatory mediators and prostaglandins, which is different from those of term infants. In addition, the secretion of endothelin is probably decreased. The purpose of this study is to monitor the changes of these substance sequentially, and to evaluate the relationship among endothelin-1, endogenous nitric oxide, and inflammatory mediators in the pathophysiology of patent ductus arteriosus in preterm infants. METHODS AND MATERIALS

1. 1.Inclusion criteria:
2. 2.Preterm infants with gestational age less than 32 weeks or birth weight less than 2000 gm.
3. 3.Informed consent
4. 4.Numbers of study population:
5. 5.Blood sample, collecting on day 1,3,7 after regular echocardiographic evaluation, is assessed for inflammatory mediator (IL-8, IL-10), nitric oxide metabolites (nitrite and nitrate), endothelin-1, and cGMP
6. 6.Statistical analysis: Student t-test testing the differences of clinical data, Wilcoxon signed rank test for comparing data obtained between the PDA and non-PDA patients, the PDA patients before and after intravenous indomethacin, and those who are responsive or refractory to the therapy.

Conditions

Patent Ductus Arteriosus

Keywords

Preterm infant, Patent ductus arteriosus, Nitric oxide,Endothelin-1

Eligibility Criteria

• Age: 0 Years - 1 Year
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Clinical diagnosis of the patency of ductus arteriosus

You may not qualify if:

• Congenital anomalies

Sponsors & Collaborators

• National Taiwan University Hospital: lead

MeSH Terms

Conditions

Ductus Arteriosus, Patent; Premature Birth

Condition Hierarchy (Ancestors)

Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Wu Shiun Hsieh, M.D

  National Taiwan University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 13, 2005
• Study Start: January 1, 2002
• Study Completion: December 1, 2002
• Last Updated: November 23, 2005

Record last verified: 2001-10