Microvascular Response in Diabetes Mellitus

NCT00160927 | Unknown

• 1 other identifier: PHRC 02-03
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We recently reported on the hand an original transient pressure-induced vasodilation (PIV) during a 5 mmHg/min increase of pressure strain using laser Doppler flowmetry. This physiological response to non noxious external local pressure strain is a widely protective cutaneous mechanism. The impairment of PIV in diabetic subjects may be relevant to the high prevalence of foot ulcer that occurs in these individuals. The aim of the project is to analyse the different physiopathological processes involved in PIV impairment in diabetic subjects as compared to matched controls.

Conditions

Diabetes Mellitus

Keywords

microcirculation; Laser doppler flowmetry; neuropathy; endothelial function

Interventions

local heating DEVICE

iontophoresis DEVICE

actylcholine DRUG

sodium nitroprusside DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diabetes

You may not qualify if:

• Non diabetic neuropathy
• Peripheral arterial disease
• pregnancy

Sponsors & Collaborators

• University Hospital, Angers: lead
• Alfediam: collaborator
• UNIVALOIRE: collaborator

Study Sites (1)

Centre hospitalier universitaire

Angers, 49933, France

RECRUITING

Related Publications (2)

• Koitka A, Legrand-Fernandez MS, Abraham P, Fizanne L, Fromy B, Sigaudo-Roussel D, Saumet JL. Low skin temperature impairs the cutaneous vasodilator response to local progressive pressure strain. Microvasc Res. 2004 Mar;67(2):203-6. doi: 10.1016/j.mvr.2003.12.001.

  PMID: 15020212 BACKGROUND

• Koitka A, Abraham P, Bouhanick B, Sigaudo-Roussel D, Demiot C, Saumet JL. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes. 2004 Mar;53(3):721-5. doi: 10.2337/diabetes.53.3.721.

  PMID: 14988257 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus

Interventions

Iontophoresis; Nitroprusside

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Therapeutics; Electrophoresis; Electrochemical Techniques; Investigative Techniques; Ferricyanides; Cyanides; Anions; Ions; Electrolytes; Inorganic Chemicals; Ferric Compounds; Iron Compounds; Hydrogen Cyanide; Nitrogen Compounds

Study Officials

• Jean Louis Saumet, MD PhD

  Centre Hospitalier Universitaire Angers

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jean Louis Saumet, MD PhD

CONTACT

+33 (0) 241.35.36.89

Pierre Abraham

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: September 9, 2005
• First Posted: September 12, 2005
• Study Start: January 1, 2003
• Study Completion: January 1, 2008
• Last Updated: March 19, 2007

Record last verified: 2007-03

Locations

FR (1)