Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

NCT00152724 | Completed

• 1 other identifier: CP96-04
• Study Type: observational
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.

Conditions

Healthy Volunteers

Keywords

Physiology; Microcirculation; Laser-Doppler Flowmetry

Outcome Measures

Primary Outcomes (1)

• Amplitude of the vasomotor response to stimuli

  1 hour

Secondary Outcomes (1)

• Kinetics of the vasomotor response to stimuli

  1 hour

Interventions

pressure strain system, iontophoresis DEVICE

scopolamin DRUG

emla DRUG

capsaicin DRUG

aspirin DRUG

clopidogrel DRUG

celecoxib DRUG

indomethacin DRUG

acetylcholine DRUG

sodium nitroprusside DRUG

brethyllium DRUG

general and local heating DEVICE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteers with no clinical signs of, or risk factors for, vascular disease

You may not qualify if:

• Smokers, Pregnancy, Allergy,

Sponsors & Collaborators

• University Hospital, Angers: lead

Study Sites (1)

Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers

Angers, 49033, France

Location

Related Publications (7)

• Tartas M, Durand S, Koitka A, Bouye P, Saumet JL, Abraham P. Anodal current intensities above 40 microA interfere with current-induced axon-reflex vasodilatation in human skin. J Vasc Res. 2004 May-Jun;41(3):261-7. doi: 10.1159/000078665. Epub 2004 May 19.

  PMID: 15153776 RESULT

• Durand S, Fromy B, Humeau A, Sigaudo-Roussel D, Saumet JL, Abraham P. Break excitation alone does not explain the delay and amplitude of anodal current-induced vasodilatation in human skin. J Physiol. 2002 Jul 15;542(Pt 2):549-57. doi: 10.1113/jphysiol.2002.022731.

  PMID: 12122152 RESULT

• Tartas M, Bouye P, Koitka A, Durand S, Gallois Y, Saumet JL, Abraham P. Early vasodilator response to anodal current application in human is not impaired by cyclooxygenase-2 blockade. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1668-73. doi: 10.1152/ajpheart.00415.2004. Epub 2004 Nov 24.

  PMID: 15563538 RESULT

• Durand S, Tartas M, Bouye P, Koitka A, Saumet JL, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol. 2004 Dec 15;561(Pt 3):811-9. doi: 10.1113/jphysiol.2004.069997. Epub 2004 Oct 21.

  PMID: 15498811 RESULT

• Durand S, Fromy B, Tartas M, Jardel A, Saumet JL, Abraham P. Prolonged aspirin inhibition of anodal vasodilation is not due to the trafficking delay of neural mediators. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R155-61. doi: 10.1152/ajpregu.00742.2002.

  PMID: 12793996 RESULT

• Durand S, Fromy B, Koitka A, Tartas M, Saumet JL, Abraham P. Oral single high-dose aspirin results in a long-lived inhibition of anodal current-induced vasodilatation. Br J Pharmacol. 2002 Oct;137(3):384-90. doi: 10.1038/sj.bjp.0704868.

  PMID: 12237259 RESULT

• Durand S, Fromy B, Bouye P, Saumet JL, Abraham P. Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms. J Physiol. 2002 Apr 1;540(Pt 1):261-9. doi: 10.1113/jphysiol.2001.013364.

  PMID: 11927685 RESULT

MeSH Terms

Interventions

Iontophoresis; Lidocaine, Prilocaine Drug Combination; Capsaicin; Aspirin; Clopidogrel; Celecoxib; Indomethacin; Acetylcholine; Nitroprusside

Intervention Hierarchy (Ancestors)

Drug Administration Routes; Drug Therapy; Therapeutics; Electrophoresis; Electrochemical Techniques; Investigative Techniques; Lidocaine; Acetanilides; Anilides; Amides; Organic Chemicals; Prilocaine; Aniline Compounds; Amines; Drug Combinations; Pharmaceutical Preparations; Polyunsaturated Alkamides; Alkenes; Hydrocarbons, Acyclic; Hydrocarbons; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Solanaceous Alkaloids; Alkaloids; Heterocyclic Compounds; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Fatty Acids; Lipids; Salicylates; Hydroxybenzoates; Ticlopidine; Thienopyridines; Thiophenes; Sulfur Compounds; Pyridines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Benzenesulfonamides; Sulfonamides; Sulfones; Pyrazoles; Azoles; Indoles; Biogenic Amines; Ferricyanides; Cyanides; Anions; Ions; Electrolytes; Inorganic Chemicals; Ferric Compounds; Iron Compounds; Hydrogen Cyanide; Nitrogen Compounds

Study Officials

• Jean Louis SAUMET, MD - PhD

  University Hospital, Angers

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2005
• First Posted: September 9, 2005
• Study Start: January 1, 1996
• Primary Completion: November 1, 2008
• Study Completion: November 1, 2008
• Last Updated: November 1, 2017

Record last verified: 2007-03

Locations

FR (1)