NCT00145678

Brief Summary

The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at P25-P50 for phase_2

Timeline
Completed

Started Jun 2004

Longer than P75 for phase_2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2004

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

September 1, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 5, 2005

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2010

Completed
Last Updated

January 6, 2015

Status Verified

January 1, 2015

Enrollment Period

5.9 years

First QC Date

September 1, 2005

Last Update Submit

January 5, 2015

Conditions

Borderline Personality DisorderAlcohol Use Disorder

Keywords

borderlinealcoholsubstancepsychodynamicpsychotherapypsychoanalytic

Outcome Measures

Primary Outcomes (1)

  • episodes of parasuicide, alcohol intoxication, institutional care

    12 months

Secondary Outcomes (1)

  • depression, dissociation, core symptoms of borderline pd, perceived social support

    12 months

Study Arms (2)

dynamic deconstructive psychotherapy

EXPERIMENTAL

weekly individual psychotherapy of 50 minute duration lasting 12-18 months

Behavioral: Psychodynamic Therapy

optimized community care

ACTIVE COMPARATOR

eclectic weekly individual and group psychotherapy, as well as drug and alcohol rehabilitation

Behavioral: Optimized Community Care

Interventions

Psychodynamic TherapyBEHAVIORAL

Dynamic deconstructive psychotherapy is a time-limited (12-18 month) manual-based form of psychodynamic therapy that aims to remediate specific neurocognitive capacities responsible for processing of emotional experiences.

Also known as: Dynamic Deconstructive Psychotherapy
dynamic deconstructive psychotherapy
Optimized Community CareBEHAVIORAL

individual and group psychotherapy in a private practice, clinic, and/or rehab setting, with an eclectic orientation

Also known as: Treatment as Usual
optimized community care

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age between 18 and 45 years
  • Meets diagnostic criteria for borderline personality disorder and for active alcohol abuse or dependence
  • At least average intelligence

You may not qualify if:

  • Meets diagnostic criteria for schizophrenia, or schizoaffective disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

SUNY Upstate Medical University, University Hospital

Syracuse, New York, 13210, United States

Location

Related Publications (4)

  • Gregory RJ. Thematic stages of recovery in the treatment of borderline personality disorder. Am J Psychother. 2004;58(3):335-48. doi: 10.1176/appi.psychotherapy.2004.58.3.335.

    PMID: 15675256BACKGROUND

  • Gregory RJ. Borderline attributions. Am J Psychother. 2007;61(2):131-47. doi: 10.1176/appi.psychotherapy.2007.61.2.131.

    PMID: 17760318BACKGROUND

  • Gregory RJ. The deconstructive experience. Am J Psychother. 2005;59(4):295-305. doi: 10.1176/appi.psychotherapy.2005.59.4.295.

    PMID: 16555459BACKGROUND

  • Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.

    PMID: 32368793DERIVED

MeSH Terms

Conditions

Borderline Personality DisorderAlcoholism

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Personality DisordersMental DisordersAlcohol-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Study Officials

  • Robert J. Gregory, M.D.

    State University of New York - Upstate Medical University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 1, 2005

First Posted

September 5, 2005

Study Start

June 1, 2004

Primary Completion

May 1, 2010

Study Completion

May 1, 2010

Last Updated

January 6, 2015

Record last verified: 2015-01

Locations

US(1)