NCT00143520

Brief Summary

This is a 6-month study to evaluate the effects of monotherapy with rivoglitazone, an insulin sensitizer, on glycemic control in newly identified type 2 diabetics or diabetics not adequately treated with other antidiabetic agents. The study tests rivoglitazone and uses a placebo and active treatment group for comparison.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
441

participants targeted

Target at P75+ for phase_2 type-2-diabetes

Timeline
Completed

Started Dec 2004

Shorter than P25 for phase_2 type-2-diabetes

Geographic Reach
1 country

74 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2004

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

September 1, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 2, 2005

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
Last Updated

May 10, 2021

Status Verified

May 1, 2021

Enrollment Period

1 year

First QC Date

September 1, 2005

Last Update Submit

May 6, 2021

Conditions

Keywords

Placebo and active control dose response study of rivoglitazone in type 2 diabetics

Outcome Measures

Primary Outcomes (1)

  • Change in HbA1c

Secondary Outcomes (1)

  • FPG, Lipids, hsCRP, Adiponectin

Interventions

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Type 2 diabetes in male or female patients
  • Between 18 and 75 years of age
  • With a HbA1c greater than or equal to 7.5% and less than 10.5% at randomization

You may not qualify if:

  • Type 1 diabetics or type 2 diabetics currently on insulin therapy
  • Patients unwilling or unable to discontinue their anti-diabetic medication(s)
  • History of ketoacidosis
  • History of therapy with rosiglitazone, troglitazone, pioglitazone

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (74)

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Birmingham, Alabama, United States

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Columbiana, Alabama, United States

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Huntsville, Alabama, United States

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Muscle Shoals, Alabama, United States

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Hot Springs, Arkansas, United States

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Jonesboro, Arkansas, United States

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Little Rock, Arkansas, United States

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Searcy, Arkansas, United States

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Sherwood, Arkansas, United States

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Los Angeles, California, United States

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Moreno Valley, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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San Mateo, California, United States

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Santa Monica, California, United States

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Torrance, California, United States

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Vista, California, United States

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West Hills, California, United States

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Newark, Delaware, United States

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Clearwater, Florida, United States

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Cocoa Beach, Florida, United States

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Jupiter, Florida, United States

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Largo, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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Palm Harbor, Florida, United States

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Pembroke Pines, Florida, United States

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Tampa, Florida, United States

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West Palm Beach, Florida, United States

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Warner Robins, Georgia, United States

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Chicago, Illinois, United States

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Gurnee, Illinois, United States

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Evansville, Indiana, United States

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Lexington, Kentucky, United States

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New Orleans, Louisiana, United States

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Detroit, Michigan, United States

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Livonia, Michigan, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Bozeman, Montana, United States

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Butte, Montana, United States

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Great Falls, Montana, United States

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Voorhees Township, New Jersey, United States

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Rochester, New York, United States

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Charlotte, North Carolina, United States

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Statesville, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Marion, Ohio, United States

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Clinton, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Medford, Oregon, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Charleston, South Carolina, United States

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Simpsonville, South Carolina, United States

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Bristol, Tennessee, United States

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Carrollton, Texas, United States

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Conroe, Texas, United States

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Houston, Texas, United States

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Midland, Texas, United States

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San Antonio, Texas, United States

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Spring, Texas, United States

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Sugar Land, Texas, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Virginia Beach, Virginia, United States

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Lakewood, Washington, United States

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Olympia, Washington, United States

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Renton, Washington, United States

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Spokane, Washington, United States

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Milwaukee, Wisconsin, United States

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Related Publications (1)

  • Truitt KE, Goldberg RB, Rosenstock J, Chou HS, Merante D, Triscari J, Wang AC. A 26-week, placebo- and pioglitazone-controlled, dose-ranging study of rivoglitazone, a novel thiazolidinedione for the treatment of type 2 diabetes. Curr Med Res Opin. 2010 Jun;26(6):1321-31. doi: 10.1185/03007991003715079.

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

rivoglitazonePioglitazone

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

ThiazolidinedionesThiazolesSulfur CompoundsOrganic ChemicalsAzolesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

September 1, 2005

First Posted

September 2, 2005

Study Start

December 1, 2004

Primary Completion

December 1, 2005

Study Completion

December 1, 2005

Last Updated

May 10, 2021

Record last verified: 2021-05

Data Sharing

IPD Sharing
Will not share

Locations