NCT00138814|UnknownPhase 3
Boost Use in Breast Conservation Radiotherapy
A Randomised Comparison of Breast Conservation With or Without Lumpectomy Radiotherapy Boost
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A Randomised Comparison of Breast Conservation With or Without Lumpectomy Radiotherapy Boost
Sponsor study identifier
interventional
680
1 country
3
Study Start
January 1997
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
December 2015
Date type not reportedThis date has not been verified as actual or estimated.
This is a two arm randomized study for patients who are undergoing radiotherapy following breast conservation surgery for breast cancer. Local recurrence of breast cancer will be compared for patients receiving boost or no boost radiotherapy.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2015
Date type not reportedThis date has not been verified as actual or estimated.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1997
Date type not reportedThis date has not been verified as actual or estimated.
August 29, 2005
Actual (reported)August 30, 2005
Actual (reported)December 2015
Date type not reportedThis date has not been verified as actual or estimated.
Local failure of breast cancer at 72 month median follow-up and 10 year median follow-up for final analysis
Local control translating to survival over 10 year median follow-up
Quality of life at yearly intervals with reference to baseline
Breast cosmesis - patient assessment and photos
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Liverpool Hospital
Sydney, New South Wales, 2170, Australia
Cancer Care Centre, St George Hospital
Sydney, New South Wales, 2217, Australia
Browne LH, Graham PH. Good intentions and ICH-GCP: Trial conduct training needs to go beyond the ICH-GCP document and include the intention-to-treat principle. Clin Trials. 2014 Dec;11(6):629-34. doi: 10.1177/1740774514542620. Epub 2014 Jul 14.
Hau E, Browne L, Capp A, Delaney GP, Fox C, Kearsley JH, Millar E, Nasser EH, Papadatos G, Graham PH. The impact of breast cosmetic and functional outcomes on quality of life: long-term results from the St. George and Wollongong randomized breast boost trial. Breast Cancer Res Treat. 2013 May;139(1):115-23. doi: 10.1007/s10549-013-2508-z. Epub 2013 Apr 12.
Associate Prof. Peter H Graham, MBBS FRANZCR
Cancer Care Centre, St George Hospital, Sydney, Australia
Dr Geoff Delaney, MBBS FRANZCR
Liverpool Hospital, Sydney, Australia
Dr Chris Fox, MBBS FRANZCR
Wollongong Hospital, Wollongong, Australia
First Submitted
August 29, 2005
First Posted
August 30, 2005
Study Start
January 1997
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
December 2015
Date type not reportedPhase 3 Study of LY353381 Vs Tamoxifen in Women With Locally Advanced or Metastatic Breast Cancer.
Contact the study team to confirm eligibility.
Wollongong Hospital
Wollongong, New South Wales, 2500, Australia
Hau E, Browne LH, Khanna S, Cail S, Cert G, Chin Y, Clark C, Inder S, Szwajcer A, Graham PH. Radiotherapy breast boost with reduced whole-breast dose is associated with improved cosmesis: the results of a comprehensive assessment from the St. George and Wollongong randomized breast boost trial. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):682-9. doi: 10.1016/j.ijrobp.2010.11.025. Epub 2011 Jan 20.
Millar EK, Graham PH, O'Toole SA, McNeil CM, Browne L, Morey AL, Eggleton S, Beretov J, Theocharous C, Capp A, Nasser E, Kearsley JH, Delaney G, Papadatos G, Fox C, Sutherland RL. Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. J Clin Oncol. 2009 Oct 1;27(28):4701-8. doi: 10.1200/JCO.2008.21.7075. Epub 2009 Aug 31.
This date has not been verified as actual or estimated.
Last Updated
December 15, 2005
Record last verified: 2005-09
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