NCT00137306

Brief Summary

Comorbid depression has been consistently linked to worse outcomes for patients in substance abuse treatment programs. Practice guidelines recommend pharmacotherapy for comorbid depression if symptoms persist after a 4-week "wash-out" period for detoxification (e.g., Veterans Health Administration; American Psychiatric Association). Medications may be considered earlier if a patient has current symptoms and a history of major depressive disorder (MDD) during periods of sobriety. Current efficacy data suggest that antidepressant medication can improve both depression and substance use outcomes among comorbid patients Guideline-concordant use of antidepressant medication for persons with comorbid substance use and depressive disorders, however, is not routine in many VA substance abuse treatment settings.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Jan 2004

Typical duration for phase_4

Geographic Reach
1 country

5 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2004

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

August 25, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 29, 2005

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2006

Completed
Last Updated

April 7, 2015

Status Verified

February 1, 2007

Enrollment Period

2.8 years

First QC Date

August 25, 2005

Last Update Submit

April 6, 2015

Conditions

Mood DisordersSubstance-Related Disorders

Keywords

Guideline AdherenceQuality Assurance, Health Care

Outcome Measures

Primary Outcomes (1)

  • Program: extent, quality of adoption of protocolPatient: scores on-depression, substance use, and functioning scales

Secondary Outcomes (1)

  • Programs: Staff satisfaction with protocol/intervention Patients: medication adherence

Study Arms (1)

Arm 1

OTHER
Procedure: Facilitate evidence-based treatment for depression

Interventions

Facilitate evidence-based treatment for depressionPROCEDURE
Arm 1

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Programs: VA's offering residential or intensive outpatient treatment for substance-related disorders in VISN 16 Patients: Veterans in residential or intensive outpatient treatment for substance-related disorders; positive screen for non-substance-induced depressive disorder

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR

No. Little Rock, Arkansas, 72114-1706, United States

Location

Southeast Louisiana Veterans Health Care System, New Orleans, LA

New Orleans, Louisiana, 70112, United States

Location

VA Gulf Coast Veterans Health Care System

Biloxi, Mississippi, 39531, United States

Location

G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS

Jackson, Mississippi, 39216, United States

Location

Oklahoma City, OK

Oklahoma City, Oklahoma, 73104, United States

Location

Related Publications (2)

  • Curran GM, Mukherjee S, Allee E, Owen RR. A process for developing an implementation intervention: QUERI Series. Implement Sci. 2008 Mar 19;3:17. doi: 10.1186/1748-5908-3-17.

    PMID: 18353186RESULT

  • Curran GM, Kirchner JE, Worley M, Rookey C, Booth BM. Depressive symptomatology and early attrition from intensive outpatient substance use treatment. J Behav Health Serv Res. 2002 May;29(2):138-43. doi: 10.1007/BF02287700.

    PMID: 12032971RESULT

MeSH Terms

Conditions

Mood DisordersSubstance-Related Disorders

Condition Hierarchy (Ancestors)

Mental DisordersChemically-Induced Disorders

Study Officials

  • Geoffrey M. Curran, PhD

    Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 25, 2005

First Posted

August 29, 2005

Study Start

January 1, 2004

Primary Completion

October 1, 2006

Study Completion

October 1, 2006

Last Updated

April 7, 2015

Record last verified: 2007-02

Locations

US(5)