NCT00127309

Brief Summary

Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant. As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid. In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect. The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jun 2005

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2005

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2005

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

August 4, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 5, 2005

Completed
Last Updated

August 24, 2005

Status Verified

July 1, 2005

First QC Date

August 4, 2005

Last Update Submit

August 23, 2005

Conditions

Alcohol Drinking

Keywords

hangoverhangover symptoms

Interventions

GlutathioneDRUG

Eligibility Criteria

Age20 Years - 40 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy
  • Males 20-40 years old
  • No allergies to alcohol

You may not qualify if:

  • Chronic disease
  • Increase in hepatic enzyme SGPT
  • Impending danger

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Piyavate Hospital

Bangkok, Bangkok, 10320, Thailand

Location

Related Publications (1)

  • L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986)

    BACKGROUND

MeSH Terms

Conditions

Alcohol Drinking

Interventions

Glutathione

Condition Hierarchy (Ancestors)

Drinking BehaviorBehavior

Intervention Hierarchy (Ancestors)

OligopeptidesPeptidesAmino Acids, Peptides, and Proteins

Study Officials

  • Staporn Jinaratana, M.D

    Piyavate Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 4, 2005

First Posted

August 5, 2005

Study Start

June 1, 2005

Study Completion

August 1, 2005

Last Updated

August 24, 2005

Record last verified: 2005-07

Locations

TH(1)