NCT00121498|Completed
Preemptive Analgesia for Abdominal Hysterectomy
Preemptive Analgesia for Post Abdominal Hysterectomy Pain Management
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Preemptive Analgesia for Post Abdominal Hysterectomy Pain Management
Sponsor study identifier
interventional
32
1 country
2
Study Start
November 2002
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
September 2003
Date type not reportedThis date has not been verified as actual or estimated.
Preemptive analgesia is defined as "analgesic intervention provided before surgery to prevent or reduce subsequent pain". By preventing central sensitization using nociceptive blockers by regional analgesia we may able to produce a painless postsurgical state. The use of preemptive analgesia was reported in various surgical procedures, such as in limb surgeries, laparoscopic procedures, mastectomy and vaginal hysterectomy. Regarding abdominal hysterectomy there are only few reports, however both, malignancies and benign cases were included and conflicting results were obtained regarding the value of preemptive analgesia. Since hysterectomy is the most frequent major surgical procedure performed in gynecology, and it is estimated that by age 64 years, 40 % of women will have had a hysterectomy, it would be of great value to optimize pain treatment in these patients. The aim of the present study was to evaluate the effectiveness of preemptive analgesia in women who undergo a transabdominal hysterectomy for benign uterine abnormalities. Hypothesis: Lidocaine (5%) injection to the scar area before incision is effective in pain reduction among women who undergo a transabdominal hysterectomy for benign uterine abnormalities .
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2003
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2002
Date type not reportedThis date has not been verified as actual or estimated.
September 2003
Date type not reportedThis date has not been verified as actual or estimated.
July 13, 2005
Actual (reported)July 21, 2005
Actual (reported)Postoperative pain scores: they were significantly lower in the study group in the first postoperative 8 hours
No significant differences between the groups were noted in analgesic consumption on the second post- operative day
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Dept. OBGYN, Rambam Medical Center
Haifa, 9602, Israel
Rambam Medical Center, Dept OBGYN
Haifa, 9602, Israel
Ali PB, Cotton BR, Williamson KM, Smith G. Intraperitoneal bupivacaine or lidocaine does not provide analgesia after total abdominal hysterectomy. Br J Anaesth. 1998 Feb;80(2):245-7. doi: 10.1093/bja/80.2.245.
Peter Jakobi, MD
Department of OBGYN, Rambam Medical Center, Technion the Bruce Rappaort Faculty of Medicine
First Submitted
July 13, 2005
First Posted
July 21, 2005
Study Start
November 2002
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
September 2003
Date type not reportedMechanism-based Choice of Therapy for Neuropathic Pain
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This date has not been verified as actual or estimated.
Last Updated
September 14, 2005
Record last verified: 2004-12
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Source: ClinicalTrials.gov.
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