Immune and Endocrine Function in Post-Traumatic Stress Disorder

NCT00100490 | Completed

• 1 other identifier: CADE-RCD3
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This is a study investigating immune function and relationships to the hypothalamic-pituitary-adrenal (HPA) axis in Post-traumatic stress disorder (PTSD) compared to controls without PTSD. The study involves 99 adult veterans and civilian subjects over a 3 year period. The study involves measuring immune and neuroendocrine parameters from blood samples obtained before and after a dexamethasone suppression test. The aim of the study is to determine whether immune alterations exist in PTSD and whether the immune-HPA axis interactions in this disorder are different from non-PTSD subjects with the future aim of studying whether immune dysregulation in PTSD may be linked to the increased risk for medical and psychiatric comorbidity in this population.

Conditions

Post-Traumatic Stress Disorders

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

* Subjects with DSM-IV criteria of PTSD and control subjects without any Axis I diagnosis, both groups of subjects are not on any psychotropic medications or medications that could interfere with the biological results, and do not have unstabilized medical conditions or neuroendocrine or immune disorders; * Do not have comorbid psychosis, bipolar disorder, or substance use disorders; * Have the capacity to give written informed consent; * Do not have abnormalities on medical evaluation/physical examination; * Are not a danger to self or others; * Women subjects are not pregnant or lactacting, and use a safe form of contraception with a negative pregnancy test.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• US Department of Veterans Affairs: lead

Study Sites (1)

Bronx VAMC

The Bronx, New York, 10468, United States

Location

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Officials

• Rachel Yehuda, Ph.D.

• Lloyd Mayer, M.D.

• Esther Sternberg, M.D.

• Bruce McEwen, Ph.D.

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: FED

Study Record Dates

• First Submitted: December 30, 2004
• First Posted: December 31, 2004
• Study Start: October 1, 1999
• Study Completion: September 1, 2002
• Last Updated: January 21, 2009

Record last verified: 2004-12

Locations

US (1)