Prevalence of HIV and Tuberculosis in Masiphumelele Township, Cape Town, South Africa

NCT00096681 | Completed Results

• 4 other identifiers: CIPRA-SA Project 3AU19AI053217CIPRAProject 3A
• Study Type: observational
• Target: 762
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to estimate the amount of HIV and tuberculosis (TB) infection in individuals 15 years and older in the Masiphumelele township of Cape Town, South Africa. Data collected in this study will be used to predict the effect of introducing anti-HIV therapy in this community.

Conditions

HIV Infections; Tuberculosis

Outcome Measures

Primary Outcomes (1)

• Number of Participants With Microbiologically Confirmed Pulmonary Tuberculosis

  Confirmed Pulmonary Tuberculosis based on the sputum smear and culture results. The sputum sample was obtained at the once off study visit.

  Pulmonary Tuberculosis diagnosed from sputum sample obtained at the study visit

Secondary Outcomes (1)

• Number of Participants With a Positive HIV Test

  HIV status at the time of the study visit

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Residents of the Masiphumelele township of Cape Town, South Africa

You may qualify if:

• Resident of the Masiphumelele township for at least 1 week prior to study entry
• Willing to provide informed consent
• Willing to comply with study requirements

Sponsors & Collaborators

• CIPRA SA: lead
• National Institute of Allergy and Infectious Diseases (NIAID): collaborator

Related Publications (2)

• Aaron L, Saadoun D, Calatroni I, Launay O, Memain N, Vincent V, Marchal G, Dupont B, Bouchaud O, Valeyre D, Lortholary O. Tuberculosis in HIV-infected patients: a comprehensive review. Clin Microbiol Infect. 2004 May;10(5):388-98. doi: 10.1111/j.1469-0691.2004.00758.x.

  PMID: 15113314 BACKGROUND

• Badri M, Wilson D, Wood R. Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: a cohort study. Lancet. 2002 Jun 15;359(9323):2059-64. doi: 10.1016/S0140-6736(02)08904-3.

  PMID: 12086758 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Sputum samples

MeSH Terms

Conditions

HIV Infections; Tuberculosis

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses

Results Point of Contact

• Title: Prof LG Bekker
• Organization: Desmond Tutu HIV Centre

Linda-Gail.Bekker@hiv-research.org.za

+2721 633 6599

Study Officials

• Linda Gail Bekker, MBChB, FCP, PhD

  Department of Medicine, University of Cape Town

  STUDY CHAIR

• James McIntyre, MBChB, MRCOG

  University of the Witwatersrand and Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK

Study Record Dates

• First Submitted: November 12, 2004
• First Posted: November 15, 2004
• Study Start: February 1, 2005
• Primary Completion: August 1, 2005
• Study Completion: February 1, 2006
• Last Updated: March 14, 2011
• Results First Posted: February 17, 2011

Record last verified: 2011-02