Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
APEX-AMI - Pexelizumab in Conjunction With Angioplasty
1 other identifier
interventional
5,745
16 countries
328
Brief Summary
In the setting of reperfusion therapy in an acute myocardial infarction using primary percutaneous intervention (PCI), the body's own inflammatory system involving the complement cascade may be harmful. This study will test the safety and efficacy of a novel complement inhibitor, pexelizumab to reduce mortality at 30 days.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Apr 2004
Typical duration for phase_3
328 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2004
CompletedFirst Submitted
Initial submission to the registry
September 14, 2004
CompletedFirst Posted
Study publicly available on registry
September 16, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2007
CompletedNovember 18, 2023
November 1, 2023
3.1 years
September 14, 2004
November 17, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Reduction of all causes of mortality
day 30
Study Arms (2)
1
PLACEBO COMPARATORPlacebo infusion
2
EXPERIMENTALPexelizumab infusion
Interventions
Eligibility Criteria
You may qualify if:
- Cardiac symptoms for at least 20 minutes within past 6 hours;
- Will undergo primary PCI;
- Has ECG evidence of acute high risk ST elevation myocardial infarction;
- Willing and able to be followed for at least 12 months.
You may not qualify if:
- Isolated low risk inferior wall myocardial infarction;
- Received fibrinolytic therapy;
- History of complement deficiency;
- Suspected neisserial infection;
- Participating in other investigational study;
- Pregnancy;
- Previous enrollment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (349)
Huntsville Hospital
Huntsville, Alabama, 35801, United States
Mayo Clinic Hospital
Phoenix, Arizona, 85054, United States
North Phoenix Heart Center
Phoenix, Arizona, United States
Northwest Medical Center
Tucson, Arizona, 85741, United States
Sparks Regional Medical Center
Fort Smith, Arkansas, 72901, United States
Arkansas State Hospital
Little Rock, Arkansas, 72211, United States
Brotman Medical Center
Beverly Hills, California, 90230, United States
Providence Saint Joseph Medical Center
Burbank, California, 91505, United States
Palomar Medical Center
Escondido, California, 92025, United States
Los Angeles Community Hospital
Los Angeles, California, 90033, United States
Memorial Medical Center
Modesto, California, 48201, United States
Sutter Memorial Hospital
Sacramento, California, 95825, United States
University of CA, San Diego Medical
San Diego, California, 92103-8784, United States
Sutter Medical Center of Santa Rosa
Santa Rosa, California, 95403, United States
Providence Holy Cross Medical Center
Valencia, California, 91355, United States
University of Colorado Hospital
Denver, Colorado, 80262, United States
St. Vincent Medical Center
Bridgeport, Connecticut, 06606, United States
University of Connecticut Health Center
Farmington, Connecticut, 06030-2202, United States
Yale - New Haven
New Haven, Connecticut, 06520, United States
George Washington University Hospital
Washington D.C., District of Columbia, 20037, United States
JFK Medical Center
Atlantis, Florida, 33462, United States
Morton Plant Hospital
Clearwater, Florida, 33756, United States
North Ridge Medical Center
Fort Lauderdale, Florida, 33308, United States
St. Luke's Hospital
Jacksonville, Florida, 32224, United States
Health First Holmes Regional Medical Center
Melbourne, Florida, 32001, United States
Florida Heart Hospital
Orlando, Florida, 32803, United States
Sarasota Memorial Hospital
Sarasota, Florida, 34239, United States
University Community Hospital
Tampa, Florida, 33613, United States
St. Luke's Regional Medical Center
Boise, Idaho, 63704, United States
Highland Park Hospital
Bannockburn, Illinois, 60015, United States
Ingalls Hospital
Harvey, Illinois, 80426, United States
Advocate Good Samaritan
Lombard, Illinois, 60148, United States
Elmhurst Hospital
Lombard, Illinois, 60148, United States
Trinity Medical Center
Moline, Illinois, 61265, United States
Saint Francis Medical Center
Peoria, Illinois, 61603, United States
Trinity Medical Center
Rock Island, Illinois, 61201, United States
Methodist Hospital
Indianapolis, Indiana, 46202, United States
VAMC
Indianapolis, Indiana, 46202, United States
Community Hospital South
Indianapolis, Indiana, 46227, United States
The Indiana Heart Hospital
Indianapolis, Indiana, 56250, United States
Munster Community Hospital
Munster, Indiana, 46321, United States
Iowa Heart
Des Moines, Iowa, 50314, United States
Via Christi Reginal Medical Center
Wichita, Kansas, 67214, United States
Central Baptist Hospital
Lexington, Kentucky, 40503, United States
University of Kentucky
Lexington, Kentucky, 40536-0200, United States
The Jewish Hospital
Louisville, Kentucky, 40202, United States
Baptist Hospital East
Louisville, Kentucky, 40207, United States
Lousiana Heart Center
Chalmette, Louisiana, 70043, United States
Lousiana Heart Hospital
Lacombe, Louisiana, 70445, United States
MCLNO at New Orleans University Campus
New Orleans, Louisiana, 70112, United States
Tulane University Hospital and Clinic
New Orleans, Louisiana, 70112, United States
Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Maine Medical Center
Portland, Maine, 04102, United States
St. Joseph Medical Center
Towson, Maryland, 21204, United States
Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
Sinai-Grace Hospital
Detroit, Michigan, 48235, United States
Spectrum Health
Grand Rapids, Michigan, 49503, United States
Borgess Medical Center
Kalamazoo, Michigan, 49048, United States
Mercy General Health Partners
Muskegon, Michigan, 49444, United States
Northern Michigan Hospital
Petoskey, Michigan, 49770, United States
St. Joseph Mercy-Oakland
Pontiac, Michigan, 48341-2982, United States
William Beaumont Hospital
Royal Oak, Michigan, 48073, United States
Covenant Medical Center
Saginaw, Michigan, 48601, United States
Saint Mary Medical Center
Saginaw, Michigan, 48601, United States
Providence Hospital
Southfield, Michigan, 48075, United States
William Beaumont Hospital
Troy, Michigan, 48085, United States
Harper University Hospital
Warren, Michigan, 48201, United States
Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
St. Mary's Duluth Clinic Health System
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Abbott Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
North Memorial Medical Center
Minneapolis, Minnesota, 55422, United States
Saint Mary Hospital
Rochester, Minnesota, 55902, United States
St. Cloud Hospital
Saint Cloud, Minnesota, 56303, United States
Methodist Hospital
Saint Louis Park, Minnesota, 55426, United States
Health East St. Joseph Hospital
Saint Paul, Minnesota, 55102, United States
University of Missouri Health Sciences Center
Columbia, Missouri, 65212, United States
St. John's Hospital
Springfield, Missouri, 65807, United States
St. Louis University Hospital
St Louis, Missouri, 63110, United States
Barnes St. Peters Hospital
St Louis, Missouri, 63122, United States
Deaconess Billings Clinic
Billings, Montana, 59101, United States
St. Elizabeth Medical Center
Lincoln, Nebraska, 68510, United States
Sunrise Hospital
Las Vegas, Nevada, 89109, United States
Trinitas Hospital
Elizabeth, New Jersey, 07202, United States
St. Joseph's Regional Medical Center
Fair Lawn, New Jersey, 07410, United States
New Mexico Heart Institute
Albuquerque, New Mexico, 87102, United States
Albany Medical Center
Albany, New York, 12211, United States
Maimonides Medical Center
Brooklyn, New York, 11219, United States
Wilson Memorial Medical Center
Johnson City, New York, 13790, United States
Winthrop University Hospital
Mineola, New York, 11504, United States
St. Vincent's Catholic Medical Center
New York, New York, 10011, United States
Bellevue Hospital Center
New York, New York, 10016, United States
Vassar Brothers Medical Center
Poughkeepsie, New York, 12601, United States
Rochester General Hospital
Rochester, New York, 14621, United States
SUNY - Upstate Medical University
Syracuse, New York, 13210, United States
Monteflore Medical Center
The Bronx, New York, 10467, United States
Presbyterian Hospital
Charlotte, North Carolina, 28204, United States
Duke University Health Systems
Durham, North Carolina, 27705, United States
Moses Cone Hospital/LeBauer Healthcare
Greensboro, North Carolina, 27401, United States
Pitt County Memorial Hospital
Greenville, North Carolina, 27834, United States
High Point Regional Health System
High Point, North Carolina, 27262, United States
Trinity Hospital
Minot, North Dakota, 58701, United States
Akron General Medical Center
Akron, Ohio, 44307, United States
VAMC Cincinnati
Cincinnati, Ohio, 45220, United States
Bethesda North Hospital
Cincinnati, Ohio, 45242, United States
The University Hospital
Cincinnati, Ohio, 45267, United States
University Hospitals of Cleveland
Cleveland, Ohio, 44103, United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
MidWest Cardiology Research Foundation
Columbus, Ohio, 43214, United States
Med Central Mansfield
Mansfield, Ohio, 44906, United States
Genesis Healthcare System
Zanesville, Ohio, 43701, United States
Midwest Regional Medical Center
Midwest City, Oklahoma, 73110, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
VA Medical Center
Oklahoma City, Oklahoma, 73104, United States
Integris Baptist Medical Center, Inc.
Oklahoma City, Oklahoma, 73112, United States
Oklahoma Heart Hospital
Oklahoma City, Oklahoma, 73120, United States
St. Charles Medical Center
Bend, Oregon, 97701, United States
Providence Portland Medical Center
Portland, Oregon, 97213, United States
Lehigh Valley Hospital
Allentown, Pennsylvania, 18105, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-2160, United States
Genesis Medical Center
Davenport, Pennsylvania, 58803, United States
Hamot Medical Center
Erie, Pennsylvania, 16550, United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
Jefferson Regional Medical Center
Pittsburgh, Pennsylvania, 15025, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15215, United States
VA Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, 15240, United States
The Chester County Hospital
West Chester, Pennsylvania, 19380, United States
York Hospital
York, Pennsylvania, 17405, United States
Rhode Island Hospital
Providence, Rhode Island, 02903, United States
Palmetto Richland Memorial Hospital
Columbia, South Carolina, 29203, United States
Sisters of Charity Providence Hospitals
Columbia, South Carolina, 29204, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57719, United States
Heart Hospital of South Dakota
Sioux Falls, South Dakota, 57108, United States
Jackson-Madison County General Hospital
Jackson, Tennessee, 38301, United States
Wellmont Holston Valley Medical Center
Kingsport, Tennessee, 37660, United States
Fort Sanders Rgional Medical Center
Knoxville, Tennessee, 37916, United States
Baptist Hospital of East Tennessee
Knoxville, Tennessee, 37920, United States
Centennial Medical Center
Nashville, Tennessee, 37203, United States
Methodist Medical Center
Oak Ridge, Tennessee, 37830, United States
Northwest Texas Healthcare System
Amarillo, Texas, 79106, United States
Seton Medical Center
Austin, Texas, 78705, United States
Presbyterian Hospital of Dallas
Dallas, Texas, 57231, United States
Medical City Dallas
Dallas, Texas, 75230, United States
Dallas Medical Center
Dallas, Texas, 75390, United States
Parkland Health & Hospital System
Dallas, Texas, 75390, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
Ben Taub General Hospital
Houston, Texas, 77030, United States
Memorial Hermann Hospital
Houston, Texas, 77030, United States
Michael E. DeBakey VA Medical Center
Houston, Texas, 77030, United States
Houston Northwest Medical Center
Houston, Texas, 77090, United States
Covenant Medical Center
Lubbock, Texas, 79410, United States
Northeast Baptist Hospital
San Antonio, Texas, 78217, United States
South Texas Veterans Health Care System Audie L. Murphy Division
San Antonio, Texas, 78258, United States
Scott & White Memorial Hospital
Temple, Texas, 76508, United States
East Texas Medical Center
Tyler, Texas, 75701, United States
Trinity Mother Frances Hospital
Tyler, Texas, 75701, United States
Citizens Medical Center
Victoria, Texas, 77901, United States
Detar Hospital
Victoria, Texas, 77901, United States
Cottonwood Hospital
Murray, Utah, 84107, United States
Inova Alexandria Hospital
Alexandria, Virginia, 22306, United States
Universitiy of Virginia Health Science Center
Charlottesville, Virginia, 22908, United States
Rockingham Memorial Hospital
Harrisonburg, Virginia, 22801, United States
Lynchburg General Hospital
Lynchburg, Virginia, 24501, United States
Herrico Doctors' Hospital - Forest
Richmond, Virginia, United States
Sentara Virginia Beach General Hospital
Virginia Beach, Virginia, 23454, United States
Winchester Medical Center
Winchester, Virginia, 22601, United States
Overtake Hospital Medical Center
Bellevue, Washington, 98004, United States
Skagit Valley Hospital
Mount Vernon, Washington, 98274, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
MultiCare Medical Center (Tacoma General Hospital)
Tacoma, Washington, 98405, United States
St. Joseph Medical Center
Tacoma, Washington, 98405, United States
West Virginia University Hospital
Morgantown, West Virginia, 26506-9157, United States
Franciscan Skemp Healthcare
La Crosse, Wisconsin, 54601, United States
Froedtert Hospital
Milwaukee, Wisconsin, 53226, United States
Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188, United States
Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
Concord Hospital
Concord, New South Wales, 2137, Australia
Gosford Hospital
Gosford, New South Wales, 2250, Australia
St. George Hospital
Kogarah, New South Wales, 2217, Australia
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
Prince of Wales Hospital
Randwick, New South Wales, 2031, Australia
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
Prince Charles Hospital
Chermside, Queensland, 4032, Australia
Townsville Hospital
Douglas, Queensland, 4814, Australia
Princess Alexandra Hospital
Wooloong Abba, Queensland, 4102, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
The Queen Elizabeth Hospital
Woodville South, South Australia, 5011, Australia
Austin Hospital
Box Hill, Victoria, 3084, Australia
Box Hill Hospital
Box Hill, Victoria, 3128, Australia
Monash Medical Centre
Clayton, Victoria, 3162, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Victorian Heart Clinic
Richmond, Victoria, 3121, Australia
Fremantle Hospital
Fremantle, Western Australia, 6160, Australia
Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
Royal Perth Hospital
Perth, Western Australia, 6000, Australia
Krankenhaus der Barmherzigen Schwestern
Linz, 4010, Austria
Univ. Klinik f. Innere Medizin II
Vienna, 1090, Austria
Wilhelminenspital
Vienna, 1171, Austria
U.Z. Gasthuisberg
Leuven, Brabant, 3000, Belgium
Helig Hartziekenhuis
Roeselare, Flanders, 8800, Belgium
ZOL Campus Sint-Jan
Genk, Limburg, 3600, Belgium
AZ Middelheim
Antwerp, 2020, Belgium
CHR de la Citadelle
Liège, 4000, Belgium
Foothills Medical Centre
Calgary, Alberta, T2N 2W8, Canada
University of Alberta Hospital
Edmonton, Alberta, T6G 2B7, Canada
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1L8, Canada
St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6, Canada
Royal Jubilee Hospital
Victoria, British Columbia, V8R 4R2, Canada
Saint John Regional Hospital - New Brunswick Heart Centre
Saint John, New Brunswick, E2L 4L2, Canada
General Hospital Health Sciences Centre
St. John's, Newfoundland and Labrador, A1B 3E4, Canada
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2, Canada
Trillium Health Center
Mississauga, Ontario, L58 2P7, Canada
Sunnybrook & Women's Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
Montreal Heart Institute/Research Centre
Montreal, Quebec, H1T 1C8, Canada
Centre Hospitale de'Universite de Montreal (Pav Notre-Dame)_
Montreal, Quebec, H2L 4M1, Canada
Hopital Sacre-Coeur de Montreal
Montreal, Quebec, H4J 1C5, Canada
Quebec Heart Institute/Laval Hospital
Sainte-Foy, Quebec, G1V 4G5, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, J1H 5N4, Canada
Regina General Hospital
Regina, Saskatchewan, S4P 0W5, Canada
Kardiologicke odd. Nemocnice Ceske Budejovice as
Caske Budejovice, Ceske Budejovice, 370 878, Czechia
I. Interni klinika, Fakultni nemocnice Hradec
Kradec Kralove, Hradec Kralove, 500 05, Czechia
Klinika kardiologie, IKEM
Prague, Prague, 14021, Czechia
Kardiologicke oddeleni, Masarykova nemocnice
Labem, Usti Nad Labem, 401 13, Czechia
Interni kardiologicka klinika, Fakultni nemocnice Brno
Brno, 625 00, Czechia
I. interni kardioangiologicka klinika, Fakultni nemocnice u Sv. Anny
Brno, 656 91, Czechia
Kardiologicke odd., Krajska neocnice Liberec
Liberec, 460 63, Czechia
I. Interni klinika, FN Olomouc
Olomouc, 775-20, Czechia
Interni klinika, FNsP Ostrava
Ostrava, 708 52, Czechia
Kardio-Troll sro and Krajska nemocnice Pardubice
Pardubice, 532 03, Czechia
Kardio-Troll sro and Krajska nemocnice Pardubice
Pardubice, 53203, Czechia
I. Interni klinika, Fakultni nemocnice Plzen
Pilsen, 304 60, Czechia
Kardiocentrum, Fakultni nemocnice Kralovske Vinohrady
Prague, 10034, Czechia
II. Interni klinika, Vseobecna fakultni nemocnice
Prague, 128 08, Czechia
Kardiologicke odd., Nemocnice Na Homoice
Prague, 150 30, Czechia
Kardiologicka klinika FN v Motole
Prague, 15006, Czechia
Kardiocentrum, Nemocnice Podlesi sro
Třinec, 739 61, Czechia
Interni klinika, Batova nemocnice
Zlín, 462 75, Czechia
Aalborg Sygehus
Aalborg, Danmark, 9100, Denmark
Skejby Sygehus
Aarhus, Danmark, 8200, Denmark
Rigshospitalet
Copenhagen, Danmark, DK-2100, Denmark
Amtssygehuset i Gentofte
Hellerup, Danmark, 2900, Denmark
Odense Universitets Hospital
Odense, 5000, Denmark
CHRU de Angers
Angers, 49100, France
Clinique Saint Joseph
Colmar, 66027, France
Cardiologie Hopital Simone Veil
Eaubonne-Montmorency, 95601, France
Centre Hospitalier de Haguenau
Haguenau, 67504, France
CHRU de Nantes
Nantes, 44000, France
Hopital Lariboisiere
Paris, 75010, France
Hopital Bichat
Paris, 75018, France
Hopital a Pitie Salpetriere
Paris, 75743, France
Hopital du Haut Leveque
Pessac, 33604, France
Hopital Pontchaillou
Rennes, 35000, France
CHRU de Rouen
Rouen, 76000, France
Centre Cardiologique du Nord
Saint-Denis, 93200, France
CHRU Hautepierre
Strasbourg, 67100, France
Hopital Rangueil
Toulouse, 31059, France
Hopital d'adultes de Brabois (CHU de Nancy)
Vandœuvre-lès-Nancy, 54511, France
Universitatsklinikum Mannheim
Mannheim, Baden-Wurttemberg, 66167, Germany
Klinikum Augsburg, Stenglinstr. 2.
Augsburg, Bavaria, 86156, Germany
Klinikum Coburg
Coburg, Bavaria, 96450, Germany
Stadt Krankenhaus Muenchen-Bogenhausen
München, Bavaria, 81925, Germany
Kerckhoff-Klinik Bad Anuheim
Bad Nauheim, Hesse, 61231, Germany
Stadt. Kliniken Kassel
Kassel, Hesse, 34125, Germany
Allgemeines Krankenhaus Celle
Celle, Lower Saxony, 29223, Germany
Herzzentrum Gottingen
Göttingen, Lower Saxony, 37075, Germany
St. Johannes Krankenhaus
Dortmund, Nordhein Westfalen, 44137, Germany
Herzzentrum Duisburg
Duisburg, Nordhein Westfalen, 47137, Germany
Kliniken der Stadt Koln
Cologne, North Rhine-Westphalia, 51109, Germany
Klinikkum Lippe
Detmold, North Rhine-Westphalia, 32756, Germany
Helios Klinikum Wuppertal GmbH
Wuppertal, North Rhine-Westphalia, 42117, Germany
Klinikkum Ludwigshafen
Ludwigshafen am Rhein, Rhineland-Palatinate, 67063, Germany
Herzzentrum
Bad Segeberg, Schleswig-Holstein, 23795, Germany
Universitatsklinik Lubeck
Lübeck, Schleswig-Holstein, 23538, Germany
Klinik fur Innere Medizin 1
Jena, Thuringia, 07740, Germany
Herz-Zentrum Bad Krozingen
Krozingen, Wurrtemberg, 79189, Germany
Universitatsklinik der Ruhr-Universitat Bochum
Bad Oeynhausen, 32545, Germany
Vivantes Klinikkum im Friedrichshain
Berlin, 10249, Germany
Vivantes Klinikum am Urban
Berlin, 10967, Germany
Allgemeines Krankenhaus St. Georg
Hamburg, 20099, Germany
Universitatsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
Centro E Malan
San Donato Milanese, Milano, 20097, Italy
Presidio Ospedaliero di Cittadella
Cittadella, Padova, 35013, Italy
U.O. Cardiologia
Reggio Emilia, Reggio Emilla, 42100, Italy
Osepdale degli Intermi
Rimni, Rimni, 47900, Italy
A.O. SS. Antonio e Biagio e Cesare Arrigo
Alessandria, 15100, Italy
Policlinico Sant'Orsola-Malpighi
Bologna, 40128, Italy
Ospedale Centrale di Bolzano
Bolzano, 39100, Italy
A.O. Spedali di Civili
Brescia, 25123, Italy
A.O. della Regione Lombardia Presidio Ospedaliero Sant'Anna
Como, 22100, Italy
Ospedale Alessandro Manzoni
Lecco, 23900, Italy
Azienda Ospedaliera Carlo Poma
Mantova, 46100, Italy
Azienda Ospedaliera di Parma - Ospedale Maggiore
Parma, 43100, Italy
Policlinico San Matteo - I.R.C.C.S.
Pavia, 27100, Italy
A. O. S. Salvatore
Pesaro, 46100, Italy
AO S. Camillo Forlanini
Roma, 00152, Italy
Cardiologia Universitaria
Torino, 10126, Italy
Ospedale S. Maria di Ca'Foncello
Treviso, 31100, Italy
Catharina Hospital
Eindhovenb, BR, 5623 EJ, Netherlands
Academic Hospital Maastricht
Maastricht, LI, 6229 HX, Netherlands
Medeisch Centrum Alkmaar
Alkmaar, North Holland, 1800 AM, Netherlands
VUMC
Amsterdam, North Holland, 1081 HV, Netherlands
OLVG
Amsterdam, North Holland, 1091 HD, Netherlands
Isla Klinieken Location De Weezenlanden
Zwolle, Overijssel, 8011 JW, Netherlands
Erasmus Medical Centre
Rotterdam, South Holland, 3015 GD, Netherlands
Medisch Centrum Rijnmond-Zuid
Rotterdam, South Holland, 3075 EA, Netherlands
Sint Antonius Hospital
Nieuwegein, Utrecht, 3435 CM, Netherlands
University Medical Center Utrecht
Ultrecht, Utrecht, 3584 CX, Netherlands
Christchurch Hospital
Christchurch, Canterbury, 8001, New Zealand
Dunedin Hospital
Dunedin, Otago, 9001, New Zealand
Waikato Hospital
Hamilton, Waikoto, 2001, New Zealand
Auckland City Hospital
Auckland, 1003, New Zealand
Wellington Hospital
Wellington, 6002, New Zealand
I Klinika Kardiologii
Katowice - Ochojec, 40-635, Poland
Klinika Chorob Serca i Naczyn
Krakow, 31-202, Poland
II Katedra i Klinika Kardiologii
Lodz, 91-347, Poland
I Klinika Choroby Wiencowej
Warsaw, 04-628, Poland
SPZOZ Dolnoslaski Szpital Specjalistyczny
Wroclaw, 50-420, Poland
Hospital Garcia de Orta - Servico de Cardiologia
Almada, Lisbon District, 2801-951 Almada, Portugal
Hospital Santa Cruz
Carnaxide, Lisbon District, 270-134, Portugal
H. Fernando da Fonesca
Amadora, 3700-376 Amadora, Portugal
Hospitals da Universidade de Coimbra
Coimbra, 3000-075 Coimbra, Portugal
Hospital Curry Cabral
Lisbon, 1069-166 Lisboa, Portugal
H. Santa Maria
Lisbon, 1600-190 LISBOA, Portugal
Hospital Sao Joao - Servico de Cardiologia
Porto, 4200-319 Porto, Portugal
Centro Hospitalar de Vila Nova de Gala
Vila Nova de Gala, 4434-502 Vila Nova de Gala, Portugal
Ciutat Sanitaria i Universitaria de Bellvitge
L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Virgen da la Arrixaca
El Palmar, Murcia, 30120, Spain
Hospital de Navarra
Pamplona, Navarre, 31008, Spain
Hospital General Universitario de Alicante
Alicante, 03010, Spain
Hospital Clinic i Provincial
Barcelona, 08036, Spain
Hospital de Leon
León, 24008, Spain
Hospital General Universitario Gregorio Maranon
Madrid, 28007, Spain
Hospital Puerta de Hierro
Madrid, 28035, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, 29010, Spain
Hopspital Virgen del Rocio
Seville, 41013, Spain
Universitetetssjukhuset Umea
Umeå, SE-901-85, Sweden
Uppsala University Hospital
Uppsala, Sweden
Kantonsspital Basel
Bassel, Bassel, 4031, Switzerland
University Hospital of Geneva
Geneva, Canton of Geneva, CH-1211, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Canton of St. Gallen, CH-9007, Switzerland
Cardiocentro Ticino
Lugano, Canton Ticino, 6900, Switzerland
Herzklinik Bodensee am Weinberg AG
Kreuzlingen, Thurgau, 8280, Switzerland
Related Publications (16)
Bagai A, Armstrong PW, Stebbins A, Mahaffey KW, Hochman JS, Weaver WD, Patel MR, Granger CB, Lopes RD. Prognostic implications of left ventricular end-diastolic pressure during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Findings from the Assessment of Pexelizumab in Acute Myocardial Infarction study. Am Heart J. 2013 Nov;166(5):913-9. doi: 10.1016/j.ahj.2013.08.006. Epub 2013 Sep 24.
PMID: 24176448DERIVEDGuptill JT, Mehta RH, Armstrong PW, Horton J, Laskowitz D, James S, Granger CB, Lopes RD. Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes. Circ Cardiovasc Interv. 2013 Apr;6(2):176-83. doi: 10.1161/CIRCINTERVENTIONS.112.000159. Epub 2013 Apr 2.
PMID: 23549644DERIVEDWesterhout CM, Pieper KS, James SK, Mahaffey KW, de Werf FV, Califf RM, Granger CB, Armstrong PW. Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Am Heart J. 2013 Mar;165(3):354-62.e2. doi: 10.1016/j.ahj.2012.12.001. Epub 2013 Jan 15.
PMID: 23453104DERIVEDPatel MR, Westerhout CM, Granger CB, Brener SJ, Fu Y, Siha H, Kim RJ, Armstrong PW. Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2013 Feb;165(2):226-33. doi: 10.1016/j.ahj.2012.10.028. Epub 2012 Nov 24.
PMID: 23351826DERIVEDTruffa AA, Granger CB, White KR, Newby LK, Mehta RH, Hochman JS, Patel MR, Pieper KS, Al-Khalidi HR, Armstrong PW, Lopes RD. Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes. JACC Cardiovasc Interv. 2012 Jul;5(7):769-76. doi: 10.1016/j.jcin.2012.03.018.
PMID: 22814783DERIVEDMartel C, Granger CB, Ghitescu M, Stebbins A, Fortier A, Armstrong PW, Bonnefoy A, Theroux P. Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2012 Jul;164(1):43-51. doi: 10.1016/j.ahj.2012.04.007. Epub 2012 Jun 15.
PMID: 22795281DERIVEDvan Diepen S, Widimsky P, Lopes RD, White KR, Weaver WD, Van de Werf F, Ardissino D, van't Hof AW, Armstrong PW, Granger CB. Transfer times and outcomes in patients with ST-segment-elevation myocardial infarction undergoing interhospital transfer for primary percutaneous coronary intervention: APEX-AMI insights. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):437-44. doi: 10.1161/CIRCOUTCOMES.112.965160. Epub 2012 May 15.
PMID: 22589297DERIVEDHudson MP, Armstrong PW, O'Neil WW, Stebbins AL, Weaver WD, Widimsky P, Aylward PE, Ruzyllo W, Holmes D, Mahaffey KW, Granger CB. Mortality implications of primary percutaneous coronary intervention treatment delays: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Circ Cardiovasc Qual Outcomes. 2011 Mar;4(2):183-92. doi: 10.1161/CIRCOUTCOMES.110.945311. Epub 2011 Feb 8.
PMID: 21304097DERIVEDHuber K, Holmes DR Jr, van 't Hof AW, Montalescot G, Aylward PE, Betriu GA, Widimsky P, Westerhout CM, Granger CB, Armstrong PW. Use of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial. Eur Heart J. 2010 Jul;31(14):1708-16. doi: 10.1093/eurheartj/ehq143. Epub 2010 May 25.
PMID: 20501476DERIVEDAlhadramy O, Westerhout CM, Brener SJ, Granger CB, Armstrong PW; APEX AMI Investigators. Is visual interpretation of coronary epicardial flow reliable in patients with ST-elevation myocardial infarction undergoing primary angioplasty? Insights from the angiographic substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2010 May;159(5):899-904. doi: 10.1016/j.ahj.2010.02.028.
PMID: 20435202DERIVEDPatel MR, Worthley SG, Stebbins A, Dill T, Rademakers FE, Valeti US, Barsness GW, Van de Werf F, Hamm CW, Armstrong PW, Granger CB, Kim RJ. Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. JACC Cardiovasc Imaging. 2010 Jan;3(1):52-60. doi: 10.1016/j.jcmg.2009.09.014. Epub 2010 Jan 12.
PMID: 20129531DERIVEDTrendelenburg M, Theroux P, Stebbins A, Granger C, Armstrong P, Pfisterer M. Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2010 May;31(10):1181-7. doi: 10.1093/eurheartj/ehp597. Epub 2010 Jan 19.
PMID: 20089518DERIVEDBrener SJ, Westerhout CM, Fu Y, Todaro TG, Moliterno DJ, Wagner GS, Granger CB, Armstrong PW; APEX-AMI Investigators. Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Am Heart J. 2009 Nov;158(5):755-60. doi: 10.1016/j.ahj.2009.09.009. Epub 2009 Oct 3.
PMID: 19853693DERIVEDArmstrong PW, Fu Y, Westerhout CM, Hudson MP, Mahaffey KW, White HD, Todaro TG, Adams PX, Aylward PE, Granger CB. Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2009 Apr 28;53(17):1503-9. doi: 10.1016/j.jacc.2009.01.046.
PMID: 19389560DERIVEDBuller CE, Fu Y, Mahaffey KW, Todaro TG, Adams P, Westerhout CM, White HD, van 't Hof AW, Van de Werf FJ, Wagner GS, Granger CB, Armstrong PW. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation. 2008 Sep 23;118(13):1335-46. doi: 10.1161/CIRCULATIONAHA.108.767772. Epub 2008 Sep 8.
PMID: 18779444DERIVEDAPEX AMI Investigators; Armstrong PW, Granger CB, Adams PX, Hamm C, Holmes D Jr, O'Neill WW, Todaro TG, Vahanian A, Van de Werf F. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51. doi: 10.1001/jama.297.1.43.
PMID: 17200474DERIVED
MeSH Terms
Interventions
Study Officials
- STUDY DIRECTOR
Thomas G Todaro, MD, JD, FACC
Procter and Gamble
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
September 14, 2004
First Posted
September 16, 2004
Study Start
April 1, 2004
Primary Completion
May 1, 2007
Study Completion
May 1, 2007
Last Updated
November 18, 2023
Record last verified: 2023-11