NCT00087828

Brief Summary

The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2000

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2000

Completed
3.7 years until next milestone

First Submitted

Initial submission to the registry

July 14, 2004

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 16, 2004

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2005

Completed
Last Updated

August 18, 2006

Status Verified

August 1, 2006

First QC Date

July 14, 2004

Last Update Submit

August 16, 2006

Conditions

Urinary Tract Infections

Keywords

Vaccinium macrocarpon

Interventions

Cranberry juice cocktailDRUG

Eligibility Criteria

Age18 Years - 64 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Good overall health

You may not qualify if:

  • History of urinary tract infections
  • Use of cranberry products or antibiotics within 1 week of study start
  • Current use of any other medication
  • Hypertension
  • Diabetes
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dept Medicinal Chemistry & Pharmacognosy, COP, UIC

Chicago, Illinois, 60612, United States

Location

Related Publications (5)

  • Ahuja S, Kaack B, Roberts J. Loss of fimbrial adhesion with the addition of Vaccinum macrocarpon to the growth medium of P-fimbriated Escherichia coli. J Urol. 1998 Feb;159(2):559-62. doi: 10.1016/s0022-5347(01)63983-1.

    PMID: 9649291BACKGROUND

  • Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994 Mar 9;271(10):751-4. doi: 10.1001/jama.1994.03510340041031.

    PMID: 8093138BACKGROUND

  • Foo LY, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod. 2000 Sep;63(9):1225-8. doi: 10.1021/np000128u.

    PMID: 11000024BACKGROUND

  • Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry. 2000 May;54(2):173-81. doi: 10.1016/s0031-9422(99)00573-7.

    PMID: 10872208BACKGROUND

  • Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios. 1988;55(224-225):173-81.

    PMID: 3063927BACKGROUND

MeSH Terms

Conditions

Urinary Tract Infections

Condition Hierarchy (Ancestors)

InfectionsUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Susan Turner, MD

    UIC

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
NIH

Study Record Dates

First Submitted

July 14, 2004

First Posted

July 16, 2004

Study Start

November 1, 2000

Study Completion

June 1, 2005

Last Updated

August 18, 2006

Record last verified: 2006-08

Locations

US(1)