NCT00087724

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of five fixed dosage levels of FK962 or placebo for 24 weeks in subjects with mild to moderate Alzheimer's disease. Patient visits are every six weeks with limited efficacy measurements at week 6 and 18.

Trial Health

60
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
510

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jul 2004

Geographic Reach
2 countries

84 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2004

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

July 12, 2004

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 14, 2004

Completed
2.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2006

Completed
Last Updated

June 7, 2012

Status Verified

June 1, 2012

First QC Date

July 12, 2004

Last Update Submit

June 6, 2012

Conditions

Interventions

FK962DRUG

Eligibility Criteria

Age50 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subject satisfies the criteria for the clinical diagnosis of probable AD
  • Subject has a score =\< 4 on the Modified Hachinski Ischemia Scale at the screening visit

You may not qualify if:

  • Subject has history or evidence of significant neurologic disease other than AD
  • Subject has a history of stroke
  • Subject has been treated for schizophrenia or recurrent mood disorder within the previous three years
  • Subject has a hematologic or solid malignancy diagnosed within five years prior to study entry
  • Subject has medically unstable COPD or asthma
  • Subject has end stage CHF (NYHA Class III or IV) or unstable angina
  • Subject has evidence of significant renal insufficiency
  • Subject has insulin-dependent diabetes mellitus or HbA1C\>8.5% at screening

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (84)

Investigational Site

Phoenix, Arizona, 85013, United States

Location

Investigational Site

Phoenix, Arizona, 85032, United States

Location

Unknown Facility

Sun City, Arizona, 85351, United States

Location

Investigational Site

Tucson, Arizona, 85724, United States

Location

Investigational Site

Little Rock, Arkansas, 72205, United States

Location

Investigational Site

Little Rock, Arkansas, 72211, United States

Location

Investigational Site

Fresno, California, 93720, United States

Location

Investigational Site

Irvine, California, 92618, United States

Location

Investigational Site

Orange, California, 92656, United States

Location

Investigational Site

San Francisco, California, 94115, United States

Location

Investigational Site

Sherman Oaks, California, 91403, United States

Location

Investigational Site

Torrance, California, 90505, United States

Location

Investigative Site

Denver, Colorado, 80249, United States

Location

Investigational Site

Denver, Colorado, 80262, United States

Location

Investigational Site

Darien, Connecticut, 06820, United States

Location

Investigational Site

Hamden, Connecticut, 06518, United States

Location

Unknown Facility

Hamden, Connecticut, 06518, United States

Location

Investigational Site

Stamford, Connecticut, 06902, United States

Location

Investigational Site

Fort Myers, Florida, 33912, United States

Location

Investigational Site

Hialeah, Florida, 33016, United States

Location

Investigational Site

Hollywood, Florida, 33021, United States

Location

Investigational Site

Miami, Florida, 33176, United States

Location

Investigational Site

North Miami, Florida, 33161, United States

Location

Investigational Site

Ocala, Florida, 34471, United States

Location

Investigational Site

Port Charlotte, Florida, 33952, United States

Location

Investigational Site

Sarasota, Florida, 34243, United States

Location

Investigational Site

Sebring, Florida, 33872, United States

Location

Investigational Site

Tampa, Florida, 33613, United States

Location

Unknown Facility

West Palm Beach, Florida, 33407, United States

Location

Investigational Site

Snellville, Georgia, 30078, United States

Location

Unknown Facility

Snellville, Georgia, 30078, United States

Location

Investigational Site

Elk Grove, Illinois, 60007, United States

Location

Investigational Site

Wichita, Kansas, 67207, United States

Location

Investigational Site

New Orleans, Louisiana, 70112, United States

Location

Unknown Facility

Baltimore, Maryland, 21208, United States

Location

Investigational Site

Newton, Massachusetts, 02459, United States

Location

Unknown Facility

Livonia, Michigan, 48152, United States

Location

Unknown Facility

Hattiesburg, Mississippi, 32401, United States

Location

Investigational Site

St Louis, Missouri, 63128, United States

Location

Investigational Site

Las Vegas, Nevada, 89102, United States

Location

Investigational Site

Long Branch, New Jersey, 07740, United States

Location

Investigational Site

Paterson, New Jersey, 08759, United States

Location

Investigational Site

Piscataway, New Jersey, 08855, United States

Location

Investigational Site

Albuquerque, New Mexico, 87102, United States

Location

Investigational Site

Albany, New York, 12208, United States

Location

Investigational Site

Buffalo, New York, 14221, United States

Location

Investigational Site

Lawrence, New York, 11559, United States

Location

Investigational Site

New York, New York, 10021, United States

Location

Investigational Site

White Plains, New York, 10605, United States

Location

Unknown Facility

Charlotte, North Carolina, 28204, United States

Location

Investigational Site

Centerville, Ohio, 45459, United States

Location

Investigational Site

Columbus, Ohio, 43210, United States

Location

Unknown Facility

Dayton, Ohio, 45408, United States

Location

Investigational Site

Dayton, Ohio, 45415, United States

Location

Investigational Site

Toledo, Ohio, 43623, United States

Location

Investigational Site

Oklahoma City, Oklahoma, 73112, United States

Location

Investigational Site

Tulsa, Oklahoma, 74104, United States

Location

Investigational Site

Eugene, Oregon, 97401, United States

Location

Investigational Site

Medford, Oregon, 97504, United States

Location

Investigational Site

Bala-Cynwyd, Pennsylvania, 19004, United States

Location

Investigational Site

Jenkintown, Pennsylvania, 19046, United States

Location

Investigational Site

Pawtucket, Rhode Island, 02860, United States

Location

Investigational Site

Johnson City, Tennessee, 37601, United States

Location

Investigational Site

Nashville, Tennessee, 37203, United States

Location

Investigational Site

Houston, Texas, 77063, United States

Location

Investigational Site

San Antonio, Texas, 78229, United States

Location

Investigational Site

Wichita Falls, Texas, 76309, United States

Location

Investigational Site

Salt Lake City, Utah, 84121, United States

Location

Investigational Site

Bennington, Vermont, 05201, United States

Location

Unknown Facility

Burlington, Vermont, 05401, United States

Location

Investigational Site

Norfolk, Virginia, 23507, United States

Location

Investigational Site

Milwaukee, Wisconsin, 53227, United States

Location

Investigational Site

Kelowna, British Columbia, V1Y3G8, Canada

Location

Investigational Site

Penticton, British Columbia, V2A5C8, Canada

Location

Investigational Site

Victoria, British Columbia, V8T5G1, Canada

Location

Investigational Site

Sydney, Nova Scotia, B1P1C6, Canada

Location

Investigational Site

Barrie, Ontario, L4M4S5, Canada

Location

Investigational Site

Greater Sudbury, Ontario, P3E6B4, Canada

Location

Investigational Site

North York, Ontario, M2J5A3, Canada

Location

Investigational Site

North York, Ontario, M6M3C5, Canada

Location

Investigational Site

Ottawa, Ontario, K1G 4C3, Canada

Location

Investigational Site

Toronto, Ontario, M6M3Z5, Canada

Location

Investigational Site

Willowdale, Ontario, M2K2Z3, Canada

Location

Investigational Site

Regina, Saskatchewan, S4T1A5, Canada

Location

MeSH Terms

Conditions

Alzheimer Disease

Interventions

N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Officials

  • Use Central Contact

    Astellas Pharma US, Inc.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

July 12, 2004

First Posted

July 14, 2004

Study Start

July 1, 2004

Study Completion

September 1, 2006

Last Updated

June 7, 2012

Record last verified: 2012-06

Locations