NCT00085891

Brief Summary

The purpose of this study is to demonstrate superior efficacy of sustained release quetiapine compared to placebo in patients with schizophrenia after receiving treatment for up to 6 weeks.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
535

participants targeted

Target at P75+ for phase_3 schizophrenia

Timeline
Completed

Started Jun 2004

Shorter than P25 for phase_3 schizophrenia

Geographic Reach
1 country

29 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2004

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

June 16, 2004

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 18, 2004

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2005

Completed
Last Updated

March 25, 2009

Status Verified

March 1, 2009

First QC Date

June 16, 2004

Last Update Submit

March 24, 2009

Conditions

Keywords

SchizophreniaSchizophrenic disorder

Outcome Measures

Primary Outcomes (1)

  • Change from baseline of the Positive and Negative Syndrome Scale (PANSS) total score at the end of treatment.

Secondary Outcomes (1)

  • Evaluation of secondary PANSS efficacy variables and Clinical Global Impression (CGI) variables at all study visits compared to baseline.

Interventions

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient is able to provide written informed consent before beginning any study related procedures
  • Patient has a documented clinical diagnosis of schizophrenia
  • Patient is able to understand and comply with the requirements of the study, as judged by a study investigator

You may not qualify if:

  • Patients with a history of non-compliance as judged by the study investigator
  • Patients with a known lack of response to previous treatment with quetiapine
  • Patients who have participated in another drug study within 4 weeks prior to enrollment into this study
  • Patients who have previously participated in this study or study D1444C00132

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (29)

Research Site

Birmingham, Alabama, United States

Location

Research Site

Cerritos, California, United States

Location

Unknown Facility

Los Angeles, California, United States

Location

Research Site

San Diego, California, United States

Location

Research Site

Santa Ana, California, United States

Location

Research Site

Washington D.C., District of Columbia, United States

Location

Research Site

Miami, Florida, United States

Location

Unknown Facility

Oak Brook, Illinois, United States

Location

Research Site

Oakbrook Terrace, Illinois, United States

Location

Research Site

New Orleans, Louisiana, United States

Location

Research Site

Rockville, Maryland, United States

Location

Unknown Facility

Brighton, Massachusetts, United States

Location

Research Site

Jackson, Mississippi, United States

Location

Research Site

St Louis, Missouri, United States

Location

Research Site

Holliswood, New York, United States

Location

Research Site

Lawrence, New York, United States

Location

Research Site

Staten Island, New York, United States

Location

Research Site

Medina, Ohio, United States

Location

Research Site

Oklahoma City, Oklahoma, United States

Location

Research Site

Norristown, Pennsylvania, United States

Location

Research Site

Philadelphia, Pennsylvania, United States

Location

Research Site

Sioux Falls, South Dakota, United States

Location

Research Site

Memphis, Tennessee, United States

Location

Research Site

Austin, Texas, United States

Location

Research Site

Houston, Texas, United States

Location

Research Site

Irving, Texas, United States

Location

Research Site

San Antonio, Texas, United States

Location

Research Site

Richmond, Virginia, United States

Location

Research Site

Kirkland, Washington, United States

Location

MeSH Terms

Conditions

Schizophrenia

Interventions

Quetiapine Fumarate

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Intervention Hierarchy (Ancestors)

DibenzothiazepinesThiazepinesThiepinsSulfur CompoundsOrganic ChemicalsHeterocyclic Compounds, 3-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • AstraZeneca Seroquel Medical Science Director, MD

    AstraZeneca

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

June 16, 2004

First Posted

June 18, 2004

Study Start

June 1, 2004

Study Completion

September 1, 2005

Last Updated

March 25, 2009

Record last verified: 2009-03

Locations