Docetaxel, Estramustine, and Thalidomide in Treating Patients With Androgen-Independent Metastatic Adenocarcinoma of the Prostate

NCT00083005 | Completed Phase 2

• 3 other identifiers: 04013204-C-0132CDR0000361758
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as docetaxel and estramustine, work in different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of prostate cancer by stopping blood flow to the tumor. Giving chemotherapy together with thalidomide may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving docetaxel and estramustine together with thalidomide works in treating patients with androgen-independent metastatic adenocarcinoma (cancer) of the prostate.

Conditions

Prostate Cancer

Keywords

adenocarcinoma of the prostate; recurrent prostate cancer; stage IV prostate cancer

Outcome Measures

Primary Outcomes (2)

• PSA response

• Toxicity

Secondary Outcomes (1)

• Survival

Interventions

docetaxel DRUG

estramustine phosphate sodium DRUG

thalidomide DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Histologically confirmed adenocarcinoma of the prostate * Metastatic disease * Androgen-independent disease * Clinically progressive disease documented by at least 1 of the following parameters: * Two consecutively rising prostate-specific antigen (PSA) levels taken at least 1 week apart * PSA ≥ 5.0 ng/mL * Continued rise in PSA 4 weeks after discontinuation of prior flutamide OR 6 weeks after discontinuation of prior bicalutamide or nilutamide (for patients treated with anti-androgen agents) * At least 1 new lesion on bone scan * Progressive measurable disease * Must have undergone bilateral surgical castration OR continue on a gonadotropin-releasing hormone agonist * No brain metastases PATIENT CHARACTERISTICS: Age * 18 and over Performance status * ECOG 0-2 Life expectancy * Not specified Hematopoietic * Absolute neutrophil count \> 1,500/mm\^3 * Platelet count ≥ 100,000/mm\^3\* * Hemoglobin ≥ 7.5 g/dL\* NOTE: \*No transfusions within the past 2 weeks Hepatic * AST and ALT \< 2.5 times upper limit of normal (ULN) * Bilirubin \< ULN (≤ 3.0 times ULN for patients with Gilbert's syndrome) * Alkaline phosphatase ≤ 2.5 times ULN OR * Fractionated hepatic alkaline phosphatase ≤ 2.5 times ULN Renal * Creatinine ≤ 1.5 mg/dL OR * Creatinine clearance ≥ 40 mL/min Cardiovascular * No transient ischemic attacks or cerebrovascular accident within the past 2 years * No myocardial infarction within the past 6 months * No uncontrolled congestive heart failure * No uncontrolled angina pectoris * No thromboembolic disease Other * No peripheral neuropathy ≥ grade 2 * No cognitive impairment that would preclude study participation or giving informed consent * No other active malignancy within the past 2 years except non-melanoma skin cancer or superficial bladder carcinoma * Fertile patients must use effective contraception for at least 1 month before, during, and for at least 1 month after study treatment PRIOR CONCURRENT THERAPY: Biologic therapy * No prior thalidomide Chemotherapy * No prior docetaxel * No prior estramustine * No prior chemotherapy for metastatic prostate cancer Endocrine therapy * See Disease Characteristics Radiotherapy * Recovered from prior radiotherapy Surgery * See Disease Characteristics * Recovered from prior surgery Other * No concurrent antiretroviral therapy for HIV-positive patients * No concurrent complementary or alternative therapy that would interact with study drugs * No concurrent herbal or nutritional products or dietary supplements that would interact with study drugs * No concurrent aprepitant as secondary prophylaxis or antiemetic treatment

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead
• National Cancer Institute (NCI): collaborator

Study Sites (2)

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office

Bethesda, Maryland, 20892-1182, United States

Location

NCI - Center for Cancer Research

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Sissung TM, Danesi R, Kirkland CT, Baum CE, Ockers SB, Stein EV, Venzon D, Price DK, Figg WD. Estrogen receptor alpha and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy. J Clin Endocrinol Metab. 2011 Feb;96(2):E368-72. doi: 10.1210/jc.2010-2070. Epub 2010 Nov 24.

  PMID: 21106711 BACKGROUND

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Docetaxel; Estramustine; Thalidomide

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Diterpenes; Terpenes; Nitrogen Mustard Compounds; Mustard Compounds; Hydrocarbons, Halogenated; Estradiol; Estrenes; Estranes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Phthalimides; Phthalic Acids; Acids, Carbocyclic; Carboxylic Acids; Piperidones; Piperidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Isoindoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Officials

• Avi S. Retter, MD

  Eastchester Center for Cancer Care

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 2
• Masking: NONE
• Purpose: TREATMENT
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 14, 2004
• First Posted: May 17, 2004
• Study Start: March 1, 2004
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: March 15, 2012

Record last verified: 2012-03

Locations

US (2)