Comparison of Popular Weight Loss Diets

NCT00079573 | Completed Phase 2

• 1 other identifier: R21AT001098-01A1
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the safety and effectiveness of three popular weight loss plans. These plans will be compared with the USDA Dietary Guidelines.

Conditions

Obesity

Keywords

Weight Loss; Obesity; Overweight; Premenopausal women; Diet

Outcome Measures

Primary Outcomes (2)

• Weight; measured at each study visit

• Percent body fat; measured at each study visit

Secondary Outcomes (3)

• Blood lipids (cholesterol, triglycerides); measured at each study visit

• Fasting insulin and glucose; measured at each study visit

• Behavioral variables; measured at each study visit

Interventions

Atkins diet (extremely low carbohydrate) BEHAVIORAL

Zone diet (low carbohydrate, high protein) BEHAVIORAL

Ornish diet (very low fat) BEHAVIORAL

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body mass index (BMI) between 27 and 40 kg/m2
• Weight stable for last 2 months
• Not actively on a weight loss plan
• No plans to move from the area over the next 2 years
• Willing to accept random assignment

You may not qualify if:

• Pregnant or breastfeeding
• Within 6 months of giving birth or planning to become pregnant in the next 2 years
• Diabetes (type 1 or 2) or history of gestational diabetes
• Renal or liver disease, active neoplasms, or recent myocardial infarction
• Hyper- or hypothyroidism
• Lipid lowering medications or medications known to affect weight/energy expenditure
• Excessive alcohol intake (self-reported, \> 3 drinks/day)
• Postmenopausal, including surgical menopause
• Currently under psychiatric care or severely clinically depressed (\> 17 on Beck Inventory)

Sponsors & Collaborators

• National Center for Complementary and Integrative Health (NCCIH): lead
• Community Foundation of Southeastern Michigan: collaborator

Study Sites (1)

Stanford Prevention Research Center

Stanford, California, 94305, United States

Location

Related Publications (1)

• Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9):969-77. doi: 10.1001/jama.297.9.969.

  PMID: 17341711 DERIVED

Related Links

• Stanford Center for Research in Disease Prevention

MeSH Terms

Conditions

Obesity; Weight Loss; Overweight

Interventions

Diet, High-Protein Low-Carbohydrate

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes

Intervention Hierarchy (Ancestors)

Diet, Carbohydrate-Restricted; Diet Therapy; Nutrition Therapy; Therapeutics; Diet, High-Protein; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Christopher D. Gardner, PhD

  Stanford University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 9, 2004
• First Posted: March 10, 2004
• Study Start: July 1, 2002
• Study Completion: June 1, 2004
• Last Updated: August 18, 2006

Record last verified: 2006-08

Locations

US (1)