Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System

NCT00078299 | Completed

• 2 other identifiers: 04012804-EI-0128
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate a system developed to grade the severity of age-related cataract, a common cause of vision loss in older adults. Cataract research requires methods to simply and accurately determine the type and severity of cataracts in order to develop new, possibly non-surgical, treatments. Patients 50 years of age and older with one of the three major age-related cataract types (nuclear, cortical, and posterior subcapsular) may be eligible for this study. Participants will be recruited from among patients enrolled in other National Eye Institute protocols. Participants will have their eyes examined independently by two ophthalmologists with a biomicroscope, a magnifying device routinely used during eye examinations. The doctors will use the new grading system to record if a cataract is present, and if so, how severe it is. The examination includes measurement of visual acuity (vision chart test) and examination of the lens, retina, pupils and eye movements. Photographs of the eye will be taken using a special camera that flashes a bright light in the eye.

Conditions

Cataract

Keywords

Cortical; Nuclear Sclerosis; Posterior Subcapsular; Photographic Methods; Reproducibility (intra and interobserver); Cataract; Agreement; Grading System

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient must understand and sign the informed consent.
• Patient must be at least 18 years of age.
• Pupillary dilation to at least 6 mm must be possible.
• Patients must have at least one natural lens present.

You may not qualify if:

• Patients below the age of 18 will be excluded from participation in this study of age-related cataract.
• \. Any condition such as corneal opacification that precludes adequate slit lamp examination and photography of the lens.

Sponsors & Collaborators

• National Eye Institute (NEI): lead

Study Sites (1)

National Eye Institute (NEI)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Steinberg EP, Javitt JC, Sharkey PD, Zuckerman A, Legro MW, Anderson GF, Bass EB, O'Day D. The content and cost of cataract surgery. Arch Ophthalmol. 1993 Aug;111(8):1041-9. doi: 10.1001/archopht.1993.01090080037016.

  PMID: 8352686 BACKGROUND

• Age-Related Eye Disease Study Research Group. The age-related eye disease study (AREDS) system for classifying cataracts from photographs: AREDS report no. 4. Am J Ophthalmol. 2001 Feb;131(2):167-75. doi: 10.1016/s0002-9394(00)00732-7.

  PMID: 11228291 BACKGROUND

• Chylack LT Jr, Leske MC, McCarthy D, Khu P, Kashiwagi T, Sperduto R. Lens opacities classification system II (LOCS II). Arch Ophthalmol. 1989 Jul;107(7):991-7. doi: 10.1001/archopht.1989.01070020053028.

  PMID: 2751471 BACKGROUND

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens Diseases; Eye Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 20, 2004
• First Posted: February 23, 2004
• Study Start: February 1, 2004
• Study Completion: April 1, 2005
• Last Updated: March 4, 2008

Record last verified: 2005-04

Locations

US (1)