EVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan
Protocol 156-03-236: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long Term Efficacy and Safety of Oral Tolvaptan Tablets in Subjects Hospitalized With Worsening Congestive Heart Failure
1 other identifier
interventional
3,600
18 countries
378
Brief Summary
The purpose of this study is to compare the effectiveness of tolvaptan or placebo in adults with worsening congestive heart failure (CHF).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Sep 2003
Typical duration for phase_3
378 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2003
CompletedFirst Submitted
Initial submission to the registry
October 20, 2003
CompletedFirst Posted
Study publicly available on registry
October 21, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2006
CompletedMay 3, 2012
May 1, 2012
2.8 years
October 20, 2003
May 2, 2012
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- Age greater than or equal to 18 years.
- Current hospitalization for chronic congestive heart failure with admission up to 48 hours prior to randomization. Chronic heart failure is defined as requiring treatment for a minimum of 30 days prior to hospitalization.
- The subject must have signs of extracellular volume expansion, defined as two or more of the following: a) jugular venous distention; b) pitting edema (\>1+); or c) dyspnea.
- NYHA Class III or IV at the time of hospitalization.
- Left Ventricular Ejection Fraction \< = 40% within one year.
You may not qualify if:
- Women who will not adhere to the reproductive precautions as outlined in the Informed Consent form.
- Positive urine pregnancy test.
- Inability to provide written informed consent.
- Cardiac surgery within 60 days of potential study enrollment, excluding percutaneous coronary interventions.
- Planned revascularization procedures, electrophysiologic (EP) device implantation, cardiac mechanical support implantation, cardiac transplantation, or other cardiac surgery within 30 days following study enrollment.
- Subjects who are on cardiac mechanical support.
- History of bi-ventricular pacer placement within the last 60 days.
- Co-morbid condition with an expected survival less than six months.
- Subjects with acute ST segment elevation myocardial infarction at the time of hospitalization.
- History of sustained ventricular tachycardia or ventricular fibrillation within 30 days, unless in the presence of an automatic implantable cardioverter defibrillator.
- History of a cerebrovascular accident within the last 30 days.
- Hemodynamically significant uncorrected primary cardiac valvular disease.
- Hypertrophic cardiomyopathy (obstructive or non-obstructive).
- CHF due to uncorrected thyroid disease, active myocarditis or known amyloid cardiomyopathy.
- Subjects with progressive or episodic neurological disease such as multiple sclerosis or history of multiple strokes.
- +12 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (378)
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
The Heart Center
Huntsville, Alabama, 35801, United States
The Heart Group
Mobile, Alabama, 36608, United States
Phoenix Memorial Hospital
Gilbert, Arizona, 85233, United States
Arizona Heart Institute
Phoenix, Arizona, 85006, United States
Saguaro Clinical Research
Tucson, Arizona, 85712, United States
Central Arkansas Veterans Healthcare Systems
Little Rock, Arkansas, 72205, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Bakersfield Memorial Hospital
Bakersfield, California, 93301, United States
Central Cardiology Medical Center
Bakersfield, California, 93301, United States
Cardiology Associates
Larkspur, California, 94939, United States
Loma Linda University Medical Center
Loma Linda, California, 92354, United States
LAC/USC Medical Center
Los Angeles, California, 90033, United States
VA Medical Center- W. Los Angeles
Los Angeles, California, 90073, United States
Mission Internal Medical Group
Mission Viejo, California, 92691, United States
ARI Clinical Trials
Redondo Beach, California, 92077, United States
San Diego Cardiac Center
San Diego, California, 92123, United States
Pacific Heart Institute
Santa Monica, California, 90404, United States
Cardiovascular Consultants Medical Group, Inc.
Walnut Creek, California, 94598, United States
Aurora Denver Cardiology Associates
Denver, Colorado, 80218, United States
University of Colorado
Denver, Colorado, 80262, United States
Heart and Vascular Clinic of North Colorado
Fort Collins, Colorado, 80528, United States
Bakus Resesarch
Norwich, Connecticut, 06360, United States
Christiana Care Health System
Newark, Delaware, 19718, United States
VA Medical Center
Washington D.C., District of Columbia, 20422, United States
Florida Cardiovascular Research
Atlantis, Florida, 33462, United States
Cardiology Associates of Fort Lauderdale
Fort Lauderdale, Florida, 33308, United States
Jacksonville Heart Center
Jacksonville, Florida, 32207, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Jacksonville Heart Center
Jacksonville Beach, Florida, 32250, United States
Melbourne Internal Medicine Assoc.
Melbourne, Florida, 32901, United States
University of Miami/ Jackson Memorial Hospital
Miami, Florida, 33136, United States
Miami Research and Education Foundation
Miami, Florida, 33156, United States
Ocala Resarch Institute
Ocala, Florida, 34480, United States
Cardiology Research Associates
Ormond Beach, Florida, 32174, United States
Charlotte Heart Group Research Center
Port Charlotte, Florida, 33952, United States
Cardiovascular Center of Sarasota
Sarasota, Florida, 34239, United States
The Heart and Vascular Institute of Florida
St. Petersburg, Florida, 33701, United States
Cardiac Disease Specialists PC
Atlanta, Georgia, 30309, United States
Atlanta Heart and Vascular Research Group
Atlanta, Georgia, 30342, United States
Georgia Heart Specialists
Covington, Georgia, 30014, United States
Idaho Cardiology Associates
Boise, Idaho, 83704, United States
Idaho Cardiology Associates
Meridian, Idaho, 83642, United States
North Shore Cardiologists
Bannockburn, Illinois, 60015, United States
Northwestern University
Chicago, Illinois, 60611, United States
Midwest Heart Research Found.
Lombard, Illinois, 60148, United States
Illinois Heart & Lung Associates
Normal, Illinois, 61761, United States
Heart Care Midwest
Peoria, Illinois, 61603, United States
The Care Group
Indianapolis, Indiana, 46260, United States
Mid America Cardiology
Kansas City, Kansas, 66160, United States
Cardiovascular Associates
Louisville, Kentucky, 40205, United States
Louisville Cardiology Medical Group
Louisville, Kentucky, 40207, United States
The Louisiana Heart Center
Chalmette, Louisiana, 70043, United States
Northshore Medical Research
Covington, Louisiana, 70433, United States
Leonard J Chabert Medical Center
Houma, Louisiana, 70360, United States
Lousiana State University Health Sciences Center
Shreveport, Louisiana, 71103, United States
Cardiac Centers of LA, LLC
Shreveport, Louisiana, 71135, United States
Androscoggin Cardiology Associates
Auburn, Maine, 04210, United States
Northeast Cardiology Associates
Bangor, Maine, 04401, United States
Maine Medical Center
Portland, Maine, 04102, United States
MidAtlantic Cardiovascular Associates
Baltimore, Maryland, 21218, United States
Midatlantic Cardiovascular Associates
Baltimore, Maryland, 21229, United States
MidAtlantic Cardiovascular Associates
Baltimore, Maryland, 21237, United States
Midatlantic Cardiovascular Associates
Bel Air, Maryland, 21014, United States
Shore Health System
Easton, Maryland, 21601, United States
MidAtlantic Cardiovascular Associates
Towson, Maryland, 21204, United States
Heart Associates, P.A.
Towson, Maryland, 21286, United States
MidAtlantic Cardiovascular Associates
Westminster, Maryland, 21157, United States
Primary Care Cardiology Research
Ayer, Massachusetts, 01432, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Beth Israel Medical Center
Boston, Massachusetts, 02215, United States
John Dingell VA Medical Center
Detroit, Michigan, 48201, United States
Nisus Research
Petoskey, Michigan, 49770, United States
William Beaumont Hospital
Royal Oak, Michigan, 48073-1026, United States
Covenant Medical Center
Saginaw, Michigan, 48602, United States
Beaumont Hospital
Troy, Michigan, 48085, United States
Michigan Heart
Ypsilanti, Michigan, 48197, United States
Minneapolis Heart Institute
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55416, United States
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Mayo Clinic, Division of Cardiology
Rochester, Minnesota, 55905, United States
Park Nicollet Heart Center
Saint Louis Park, Minnesota, 55426, United States
Regions Hospital Cardiology Research
Saint Paul, Minnesota, 55101, United States
St. Paul Heart Clinic
Saint Paul, Minnesota, 55102, United States
Cardiology Associates of North Mississippi
Tupelo, Mississippi, 38801, United States
Missouri Cardiovascular Specialists
Columbia, Missouri, 65201, United States
VA Medical Center- Kansas City
Kansas City, Missouri, 64128, United States
St. Louis University
St Louis, Missouri, 63110, United States
Bryan LGH Heart Institute
Lincoln, Nebraska, 68516, United States
Heart Consultants
Omaha, Nebraska, 68122, United States
New England Heart Institute
Manchester, New Hampshire, 03102, United States
Morristown Memorial Hospital
Morristown, New Jersey, 07962-1956, United States
University of Medicine and Dentistry of New Jersey
Newark, New Jersey, 07103, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
Garden State Cardiology
Paramus, New Jersey, 07652, United States
Albany Associates in Cardiology
Albany, New York, 12212, United States
Cardiology Associates, P.C.
Johnson City, New York, 13790, United States
North Shore University Hospital
Manhasset, New York, 11030, United States
St. Vincents Hospital and Medical Center
New York, New York, 10011, United States
St. Lukes-Roosevelt Hospital Centers
New York, New York, 10019, United States
New York Presbyterian Hospital
New York, New York, 10032, United States
St. Francis Hospital
Roslyn, New York, 11576, United States
SUNY
Syracuse, New York, 13230, United States
South Bay Cardiovascular Associates
West Islip, New York, 11795, United States
Buffalo Cardiology and Pulmonary Associates
Williamsville, New York, 14221, United States
Asheville Cardiology Associates
Asheville, North Carolina, 28803, United States
Alamance Regional Medical Center
Burlington, North Carolina, 27215, United States
University of North Carolina
Chapel Hill, North Carolina, 27514, United States
Mid Carolina Cardiology
Charlotte, North Carolina, 28204, United States
Durham VA Medical Center
Durham, North Carolina, 27705, United States
Duke Cardiology Research
Durham, North Carolina, 27710, United States
Pitt County Memorial Hospital, The Heart Center
Greenville, North Carolina, 28735, United States
Hendersonville Cardiology
Hendersonville, North Carolina, 28739, United States
Akron General Medical Center
Akron, Ohio, 44307, United States
Clinical Research Limited
Canton, Ohio, 44718, United States
Sterling Research Group
Cincinnati, Ohio, 45219, United States
The Lindner Clinical Trial Center
Cincinnati, Ohio, 45219, United States
Midwest Cardiology Research Foundation
Columbus, Ohio, 43214, United States
The Dayton Heart Center
Dayton, Ohio, 45414, United States
Cleveland Cardiovascular Research
Fairview Park, Ohio, 44126, United States
North Ohio Research Limited
Lorain, Ohio, 44052, United States
North Ohio Research Limited
Sandusky, Ohio, 44870, United States
Northwest Ohio Cardiology Consultants
Toledo, Ohio, 43615, United States
Integris Heart Research Center
Oklahoma City, Oklahoma, 73112, United States
Oklahoma Cardiovascular Research Group
Oklahoma City, Oklahoma, 73120, United States
Oregon Health and Science University
Portland, Oregon, 97230, United States
Cardiology Consultants of Philadelphia
Philadelphia, Pennsylvania, 19146, United States
The Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15224, United States
Guthrie Clinic, LTD
Sayre, Pennsylvania, 18840, United States
Buxmont Cardiology Associates, PC
Sellersville, Pennsylvania, 18960, United States
Cardiology Associates of West Reading
West Reading, Pennsylvania, 19611, United States
Rhode Island Hospital
Providence, Rhode Island, 02905, United States
Medical University of South Carolina
Charleston, South Carolina, 29401, United States
Ralph H. Johnson VAMC
Charleston, South Carolina, 29401, United States
South Carolina Heart Center
Columbia, South Carolina, 29204, United States
The Chattanooga Heart Institute
Chattanooga, Tennessee, 37404, United States
Cardiovascular Associates
Kingsport, Tennessee, 37660, United States
Baptist Clinical Research Center
Memphis, Tennessee, 38120, United States
Stern Cardiovascular Center
Memphis, Tennessee, 38120, United States
Vanderbilt Clinical Trials Center
Nashville, Tennessee, 37212, United States
The Cardiology Group
Tullahoma, Tennessee, 37388, United States
Austin Cardiovascular Associates
Austin, Texas, 78705, United States
Southeast Texas Cardiology Associates
Beaumont, Texas, 77702, United States
Cardiopulmonary Research Science and Technology Institute
Dallas, Texas, 75230, United States
University of Texas Medical Branch
Galveston, Texas, 77555-0553, United States
Cardiology Associates Covenant Medical Group
Lubbock, Texas, 79410, United States
McAllen Heart Clinic
McAllen, Texas, 78503, United States
University of Texas Health Science Center
San Antonio, Texas, 78229-3900, United States
Wilford Hall Medical Center,
San Antonio, Texas, 78236, United States
Scott & White Clinic Division of Cardiology
Temple, Texas, 76508, United States
VA Salt Lake City Health Care System
Salt Lake City, Utah, 84148, United States
University of Virginia Medical Center
Charlottesville, Virginia, 22908, United States
The Cardiovascular Group PC
Fairfax, Virginia, 22031, United States
Inova Institute of Research
Falls Church, Virginia, 22042, United States
Medical College of Virginia
Richmond, Virginia, 23219, United States
Cardiovascular Associates of Virginia
Richmond, Virginia, 23225, United States
Roanoke Heart Institute
Roanoke, Virginia, 24014, United States
Empire Health Services
Spokane, Washington, 99204, United States
Rockwood Clinic
Spokane, Washington, 99204, United States
CAMC Clinical Trials
Charleston, West Virginia, 25304, United States
Wisconsin Center For Clinical Research
Elkhorn, Wisconsin, 53121, United States
Clinica Constituyentes de Moron
Buenos Aires, Argentina
Clinica Modelo de Moron
Buenos Aires, Argentina
Fundacion Favaloro
Buenos Aires, Argentina
Hospital Argerich
Buenos Aires, Argentina
Hospital Churruca
Buenos Aires, Argentina
Hospital Eva Peron
Buenos Aires, Argentina
Hospital Nacional Dr. Alejandro Posadas
Buenos Aires, Argentina
Hospital de Clinicas
Capital Federal, Argentina
Hospital Fernandez
Capital Federal, Argentina
Hospital Italiano de Buenos Aires
Capital Federal, Argentina
Hospital Privado Antartida
Capital Federal, Argentina
Hospital Ramos Mejia
Capital Federal, Argentina
Policlinica Bancaria
Capital Federal, Argentina
Sanatorio Municipal "Julio A. Mendez"
Capital Federal, Argentina
Instituto de Cardiologia J. F. Cabral
Corrientes, Argentina
Hospital Allende
Córdoba, Argentina
Hospital Italiano de Cordoba
Córdoba, Argentina
Hospital Militar de Cordoba
Córdoba, Argentina
Hospital Privado Centro Medico de Cordoba
Córdoba, Argentina
Hospital Central de San Isidro
San Isidro, Argentina
AZ Middelheim
Antwerp, Belgium
AZ Imelda Ziekenhuis
Bonheiden, Belgium
Clinique St Elisabeth Place Louise
Namur, Belgium
Cliniques UCL Mont-Godinne
Yvoir, Belgium
Hospital Santa Isabel da Santa Casa de Misericordia da Bahia
Salvador, Estado de Bahia, 40050-410, Brazil
Fundacao Bahiana de Cardiologia- Hospital Universitario Professor Edgard Santos
Salvador, Estado de Bahia, 40140-060, Brazil
Hospital das Clinicas da Universidade Federal de Goias
Goiânia, Goiás, 74605-050, Brazil
Hospital Governador Israel Pinheiro
Belo Horizonte, Minas Gerais, 30130-110, Brazil
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Minas Gerais, 30150-221, Brazil
Hospital Evangelico de Curitiba
Curitiba, Paraná, 80730-150, Brazil
Hospital Nossa Senhora das Gracas
Curitiba, Paraná, 80810-040, Brazil
Santa Casa de Misericordia do Rio de Janeiro
Rio de Janeiro, Rio de Janeiro, 20020-020, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Hospital das Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-003, Brazil
Hospital Mae de Deus
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Hospital Nossa Senhora da Conceica
Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Hospital e Maternidade Celso Pierro
Campinas, São Paulo, 13059-740, Brazil
Hospital de Base da Faculdade de Medicina de Sao Jose do Rio Preto
Sao Jose de Rio Preto, São Paulo, 15090-020, Brazil
IMC- Instituto de Molestias Cardiovasculares
São José do Rio Preto, São Paulo, 15015-210, Brazil
Instituto do Coracao do Hospital das Clinicas- Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, São Paulo, 05403-000, Brazil
Hospital Universitario Onofre Lopes
Natal, 59012-310, Brazil
Hospital das Clínicas de Porto Alegre
Porto Alegre, 90035-003, Brazil
Hospital Universitario Pedro Ernesto
Rio de Janeiro, 20551-030, Brazil
Peter Loougheed Center
Calgary, Alberta, T1Y6J4, Canada
Surrey Memorial Hospital
Surrey, British Columbia, V3V1Z2, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R4R2, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
Health Sciences Center
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Brampton Research Associates
Brampton, Ontario, L6V1B4, Canada
Greater Niagara General Hospital
Niagara Falls, Ontario, L2E6Y2, Canada
Lakeridge Health Oshawa
Oshawa, Ontario, L1G2B9, Canada
Scarborough Cardiology Research
Scarborough Village, Ontario, M1E5E9, Canada
Cardiology Research Associates
Scarborough Village, Ontario, M2S4V5, Canada
The Scarborough Hospital
Toronto, Ontario, M1P 2V5, Canada
St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
University Health Network, Toronto Western Hospital
Toronto, Ontario, M5G 2C4, Canada
Centre Hospitalier de l'Universite de Sherbrooke
Fleurimond, Quebec, J1H 5N4, Canada
CHRDL
Joliette, Quebec, J6E6J2, Canada
Invascor Clinical Research
Longueuil, Quebec, J4M 1E1, Canada
Montreal Heart Institute
Montreal, Quebec, H1T1C8, Canada
Royal Victoria Hospital
Montreal, Quebec, H3A1A1, Canada
Montreal General Hospital
Montreal, Quebec, H3G 1A4, Canada
Hotel-Dieu de Saint-Jerome
Saint-Jérôme, Quebec, J7Z 5T3, Canada
I. interni kardio-angiologicka klinika LF MU
Brno, Czechia
Interni oddeleni
Jablonec nad Nisou, Czechia
Interni oddeleni
Náchod, Czechia
Interni klinika, Oddeleni Interna I, Kardiologie
Pardubice, Czechia
Interni oddeleni
Písek, Czechia
I.Interni klinika
Plzen-Lochotin, Czechia
I.Interni oddeleni
Prague, Czechia
II.Interni klinika
Prague, Czechia
Kardiologicka klinika
Prague, Czechia
Kardiologicke oddeleni
Prague, Czechia
Klinika kardiologie
Prague, Czechia
Interni oddeleni
Ústí nad Labem, Czechia
Interni klinika IPVZ
Zlín, Czechia
Centre Hospitalier Regional d'Arras-Service de Cardiologie
Arras, France
Hopital General Henri Duffaut
Avignon, France
Centre Hospitalier Jeanne d'Arc
Bar-le-Duc, France
Hopital Louis Pradel
Bron, France
Cabinet de Cardiologie et d'Explorations
Essey-lès-Nancy, France
Centre Hospitalier
Langres, France
CHU Montpellier
Montpellier, France
Centre Hospitalo-Universitaire de Nantes-Service de Cardiologie
Nantes, 44093, France
Hopital Pasteur
Nice, France
Centre Cardiologique du Nord
Saint-Denis, France
Groupe Hospitalier Rangueil-Larrey CHU
Toulouse, 31403, France
Centre Hospitalier Universitaire de Nancy-Brabois
Vandœuvre-lès-Nancy, France
Klinikum Augsburg
Augsburg, Germany
Herzzentrum Bad Krozingen
Bad Krozingen, Germany
Herz- und Gefabklinik Bad Neustadt
Bad Neustadt-Saale, Germany
Vivantes Klinikum Neukoln
Berlin, Germany
Klinikum der Universitat zu Koln
Cologne, Germany
Akademisches Lehrkrankenhaus d. HGS Essen
Essen, Germany
Universitatsklinik Essen
Essen, Germany
Georg-August-Universitat Gottingen
Göttingen, Germany
Universitatsklinikum der
Greifswald, Germany
Klinikum der Medizinischen Fakultat
Halle, Germany
Universitatsklinikum Eppendorf
Hamburg, Germany
Medizinische Universitätsklinik
Heidelberg, Germany
Universitatsklinikum Heidelberg
Heidelberg, Germany
Universitatsklinikum des Saarland
Homburg/Saar, Germany
Friedrich Schiller Universitat Jena
Jena, Germany
University Leipzig
Leipzig, Germany
Universitatsklinikum Munster
Münster, Germany
Herz- und Diabetes Zentrum Nordrhein-Westfalen
Oeyenhausen, Germany
Universitat Regensburg
Regensburg, Germany
Marienkrankenhaus Soest
Soest, Germany
Robert-Bosch-Krankenhaus
Stuttgart, Germany
Ospedale Civile S. Giuseppe
Albano Laziale, Italy
Azienda Ospedaliera S. Michele
Cagliari, Italy
Ospedale Civile
Capri city, Italy
Azienda USL n. 6 Ospedale Civile
Cecina, Italy
Poliambulatorio Valdichiana Ospedale di Cortona
Cortona, Italy
Centro Cardiologico Monzino
Milan, Italy
Ospedale Nigaurda Ca Granda
Milan, Italy
Fondazione Salvatore Maugeri
Montescano, Italy
Presidio Ospedaliero Villa Sofia
Palmero, Italy
Ospedali Riunti
Parma, Italy
IRCCS Policlinico S. Matteo
Pavia, Italy
IRCCS- Fondazione Salvatore Maugeri
Pavia, Italy
Ospedale S. Maria delle Grazie
Pozzuoli, Italy
Ospedale S. Bartolomeo
Sarzana, Italy
Ospedali Civile SS Annunziata
Sassari, Italy
Jeroen Bosch Ziekenhus (location Groot Ziekengasthius=GZG)
's-Hertogenbosch, Netherlands
Sint Lucas Andreas Ziekenhuis (loc. Lucas)
Amsterdam, Netherlands
Gelre Ziekenhuis (location Juliana)
Apeldoorn, Netherlands
Ziekenhuis Gooi Noord
Blaricum, Netherlands
Deventer Ziekenhuis
Deventer, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Oosterschelde Ziekenhuizen
Goes, Netherlands
Martini Ziekenhuis (Loc. Martini Paviljoen)
Groningen, Netherlands
Spaarne Ziekenhuis
Heemstede, Netherlands
Ziekenhuis Hilversum
Hilversum, Netherlands
Canisius-Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Medisch Centrum Haaglanden (location Westeinde)
The Hague, Netherlands
Isala Klinieken (Loc. Sophia)
Zwolle, Netherlands
Hjerte med. Avd. Haukeland Universitets Sykehus
Bergen, Norway
Nordlandsykehuset
Bodø, Norway
Hjertemed.avd. Akershus Universitetssykenhus
Nordbyhagen, Norway
Diakonhjemmets sykehus Oslo
Oslo, Norway
Med. Avd. Sykenhuset Telemark
Skien, Norway
Stavanger Helseforskning
Stavanger, Norway
Oddzial Kardiologii
Bydgoszcz, Poland
Oddzial Kardiologii
Krakow, Poland
Oddzial Kardiologii
Lodz, Poland
Oddzial Kardiologiczny
Opole, Poland
Oddzial Kardiologii
Ostrowiec Świętokrzyski, Poland
Oddzial Chorob Wewnetrznych
Oława, Poland
Oddzial Kardiologiczny
Piotrkow Trybunalski, Poland
Oddzial Kardiologiczny
Płock, Poland
Oddzial Kardiologii
Sieradz, Poland
Oddzial Kardiologii
Torun, Poland
Katedra i Oddzial Kliniczny Kardiologii Slaskiej Akademii
Tychy, Poland
I Klinika Choroby Wiencowej
Warsaw, Poland
Katedra i Klinika Chorab Wewnetrznych i Kardiologii
Warsaw, Poland
Oddzial Kardiologii
Włocławek, Poland
Spitalul Judetean Brasov, Sectia de Cardiologie
Brasov, Romania
Institutul de Boli Cardiovasculare
Bucharest, Romania
Spitalul Caritas, Clinica Medicala
Bucharest, Romania
Spitalul de Urgenta Floreasca, Clinica de Cardiologie
Bucharest, Romania
Spitalul Universitar de Urgenta Bucuresti
Bucharest, Romania
Spitalul Universitar de Urgenta
Bucharest, Romania
Institutul Inimii, Prof.N. Stancioiu
Cluj-Napoca, Romania
Centrul de Cardiologie Craiova
Craiova, Romania
Spitalul Clinic Universitar ,,Sf. Spiridon"
Iași, Romania
Spitalul Clinic Judetean Mures
Târgu Mureş, Romania
Institutul de Boli Cardiovasculare Timisoara
Timișoara, Romania
Botkins Moscow City Hospital
Moscow, Russia
Burdenko Main Military Clinical Hospital
Moscow, Russia
Cardiology Research Center
Moscow, Russia
Central Clinical Hospital Presidential
Moscow, Russia
City Clinical Hospital 2
Moscow, Russia
Institute of Physico-Chemical Medicine
Moscow, Russia
Medical Center of General Management
Moscow, Russia
Moscow Medical Academy
Moscow, Russia
Moscow Regional Research Clinical Institute n.a. Vishnevsky
Moscow, Russia
Moscow State University of Medicine and Dentistry - City Hospital #11
Moscow, Russia
Moscow State University of Medicine and Dentistry - City Hospital #40
Moscow, Russia
Moscow State University of Medicine and Dentistry
Moscow, Russia
Russian State Medical University
Moscow, Russia
Veterans Hospital #3
Moscow, Russia
Cardiology Research Institute of the Ministry of Health of the Russian Federation
Saint Petersburg, Russia
City Alexandrovsky Hospital, ICU Department
Saint Petersburg, Russia
City Hospital #31
Saint Petersburg, Russia
City Hospital 8
Saint Petersburg, Russia
Military Medical Academy
Saint Petersburg, Russia
St. Elisabeth City Hospital
Saint Petersburg, Russia
St. Petersburg Clinical Hospital of Russian Academy of Sciences
Saint Petersburg, Russia
St. Petersburg Dzanelidze State Scientific Research Institute for Emergency Medical Care
Saint Petersburg, Russia
St. Petersburg Medical Postgraduate Academy
Saint Petersburg, Russia
St. Petersburg State University
Saint Petersburg, Russia
Hospital de Torrecardenas
Almería, Spain
Hospital Clinic y Provincial
Barcelona, Spain
Hospital de Cruces
Bilbao, Spain
Hospital Reina Sofia, in Cordoba
Córdoba, Spain
Hospital Doce de Octubre
Madrid, Spain
Hospital Severo Ochoa
Madrid, Spain
Hospital Universitari de Tarragona Joan XXIII
Tarragona, Spain
Hospital General Universitario de Valencia
Valencia, Spain
Avd. for intermedicin
Gothenburg, Sweden
Medicinkliniken
Gothenburg, Sweden
Kardiologkliniken
Linköping, Sweden
Kardiologkliniken
Malmo, Sweden
Forskiningsenheten,
Mölndal, Sweden
Enheten for internmedicin, Karolinska Institutet
Stockholm, Sweden
Hjartkliniken, M84
Stockholm, Sweden
Kardiologkliniken
Stockholm, Sweden
Hjartcentrum,
Umeå, Sweden
Cardiologkliniken, Avd 50F
Uppsala, Sweden
Cardiocentro Ticino
Lugano, Switzerland
Bradford Royal Infirmary
Bradford, United Kingdom
Castle Hill Hospital
Cottingham, United Kingdom
Leeds General Infirmary
Leeds, United Kingdom
Northern Manchester General Hospital
Manchester, United Kingdom
Scunthorpe General Hospital
Scunthorpe, United Kingdom
Related Publications (12)
Oka T, Tighiouart H, McCallum W, Tuttle M, Isaka Y, Konstam MA, Udelson JE, Sarnak MJ. Thresholds of Kidney Function Decline and Congestion Status and Their Relation with Outcomes among Discharged Heart Failure Patients. Clin J Am Soc Nephrol. 2025 Jul 11;20(9):1215-1225. doi: 10.2215/CJN.0000000768.
PMID: 40643971DERIVEDHejjaji V, Tang Y, Coles T, Jones PG, Reeve BB, Mentz RJ, Spatz ES, Dunlay SM, Caldwell B, Saha A, Tarver ME, Tran A, Patel KK, Henke D, Pina IL, Spertus JA. Psychometric Evaluation of the Kansas City Cardiomyopathy Questionnaire in Men and Women With Heart Failure. Circ Heart Fail. 2021 Sep;14(9):e008284. doi: 10.1161/CIRCHEARTFAILURE.120.008284. Epub 2021 Sep 1.
PMID: 34465123DERIVEDTer Maaten JM, Valente MA, Damman K, Cleland JG, Givertz MM, Metra M, O'Connor CM, Teerlink JR, Ponikowski P, Bloomfield DM, Cotter G, Davison B, Subacius H, van Veldhuisen DJ, van der Meer P, Hillege HL, Gheorghiade M, Voors AA. Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure. Circ Heart Fail. 2016 Jun;9(6):e002845. doi: 10.1161/CIRCHEARTFAILURE.115.002845.
PMID: 27266853DERIVEDAmbrosy AP, Khan H, Udelson JE, Mentz RJ, Chioncel O, Greene SJ, Vaduganathan M, Subacuis HP, Konstam MA, Swedberg K, Zannad F, Maggioni AP, Gheorghiade M, Butler J. Changes in Dyspnea Status During Hospitalization and Postdischarge Health-Related Quality of Life in Patients Hospitalized for Heart Failure: Findings From the EVEREST Trial. Circ Heart Fail. 2016 May;9(5):e002458. doi: 10.1161/CIRCHEARTFAILURE.115.002458.
PMID: 27140204DERIVEDMentz RJ, Greene SJ, Ambrosy AP, Vaduganathan M, Subacius HP, Swedberg K, Maggioni AP, Nodari S, Ponikowski P, Anker SD, Butler J, Gheorghiade M. Clinical profile and prognostic value of anemia at the time of admission and discharge among patients hospitalized for heart failure with reduced ejection fraction: findings from the EVEREST trial. Circ Heart Fail. 2014 May;7(3):401-8. doi: 10.1161/CIRCHEARTFAILURE.113.000840. Epub 2014 Apr 15.
PMID: 24737459DERIVEDHauptman PJ, Burnett J, Gheorghiade M, Grinfeld L, Konstam MA, Kostic D, Krasa HB, Maggioni A, Ouyang J, Swedberg K, Zannad F, Zimmer C, Udelson JE; Everest Investigators. Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. J Card Fail. 2013 Jun;19(6):390-7. doi: 10.1016/j.cardfail.2013.04.001. Epub 2013 May 14.
PMID: 23743487DERIVEDAmbrosy AP, Vaduganathan M, Mentz RJ, Greene SJ, Subacius H, Konstam MA, Maggioni AP, Swedberg K, Gheorghiade M. Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial. Am Heart J. 2013 Feb;165(2):216-25. doi: 10.1016/j.ahj.2012.11.004. Epub 2012 Dec 29.
PMID: 23351825DERIVEDAllen LA, Gheorghiade M, Reid KJ, Dunlay SM, Chan PS, Hauptman PJ, Zannad F, Konstam MA, Spertus JA. Identifying patients hospitalized with heart failure at risk for unfavorable future quality of life. Circ Cardiovasc Qual Outcomes. 2011 Jul;4(4):389-98. doi: 10.1161/CIRCOUTCOMES.110.958009. Epub 2011 Jun 21.
PMID: 21693723DERIVEDO'Connor CM, Miller AB, Blair JE, Konstam MA, Wedge P, Bahit MC, Carson P, Haass M, Hauptman PJ, Metra M, Oren RM, Patten R, Pina I, Roth S, Sackner-Bernstein JD, Traver B, Cook T, Gheorghiade M; Efficacy of Vasopressin Antagonism in heart Failure Outcome Study with Tolvaptan (EVEREST) investigators. Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program. Am Heart J. 2010 May;159(5):841-849.e1. doi: 10.1016/j.ahj.2010.02.023.
PMID: 20435194DERIVEDBlair JE, Zannad F, Konstam MA, Cook T, Traver B, Burnett JC Jr, Grinfeld L, Krasa H, Maggioni AP, Orlandi C, Swedberg K, Udelson JE, Zimmer C, Gheorghiade M; EVEREST Investigators. Continental differences in clinical characteristics, management, and outcomes in patients hospitalized with worsening heart failure results from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) program. J Am Coll Cardiol. 2008 Nov 11;52(20):1640-8. doi: 10.1016/j.jacc.2008.07.056.
PMID: 18992654DERIVEDGheorghiade M, Konstam MA, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Cook T, Ouyang J, Zimmer C, Orlandi C; Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators. Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. JAMA. 2007 Mar 28;297(12):1332-43. doi: 10.1001/jama.297.12.1332. Epub 2007 Mar 25.
PMID: 17384438DERIVEDKonstam MA, Gheorghiade M, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K, Udelson JE, Zannad F, Cook T, Ouyang J, Zimmer C, Orlandi C; Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators. Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA. 2007 Mar 28;297(12):1319-31. doi: 10.1001/jama.297.12.1319. Epub 2007 Mar 25.
PMID: 17384437DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
October 20, 2003
First Posted
October 21, 2003
Study Start
September 1, 2003
Primary Completion
July 1, 2006
Study Completion
July 1, 2006
Last Updated
May 3, 2012
Record last verified: 2012-05