Study of PI-88 in Patients With Advanced Melanoma

NCT00068172 | Completed Phase 1

• 2 other identifiers: PR88201PR88201A
• Study Type: interventional
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether PI-88 is safe and effective in the treatment of advanced melanoma.

Conditions

Melanoma

Outcome Measures

Primary Outcomes (1)

• Progression-free survival by RECIST criteria

Secondary Outcomes (4)

• Response rate

• Time to progression

• Overall survival

• Biological activity in tumor biopsy specimens

Interventions

PI-88 DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Current diagnosis of metastatic melanoma, where other effective therapy is not available or has failed.
• Measurable disease. Metastatic lesions must be measurable by MRI or CT, and cutaneous lesions by physical examination.
• Aged at least 18 years.
• Have voluntarily given written informed consent to participate in this study.
• Performance status: ECOG 0 - 2 (Karnofsky 70 -100%)
• Life expectancy of at least 3 months.
• Neutrophil count greater than 1.5 x 109/L (1,500/mm3)
• Calculated creatinine clearance, using the Cockcroft-Gault formula, greater than 60 mL/min. If just below 60 mL/min, then GFR greater than 60 mL/min as determined by EDTA or DTPA scan.
• Platelet count at least 100 x 109/L (100,000/mm3)
• Bilirubin less than 1.5 x ULN
• AST and ALT up to 2 x ULN, except in the presence of liver metastases; up to 5 x ULN.
• Prothrombin time less than 1.5 x ULN
• APTT normal (20 - 34 sec)

You may not qualify if:

• History of allergy and/or hypersensitivity to anti-coagulants/thrombolytic agents, especially heparin.
• Chemotherapy, investigational or hormonal therapy in the previous 4 weeks.
• Radiotherapy to a major bone marrow bearing area such as pelvis, femoral heads, lumbar-sacral spine, within the previous 4 weeks. Radiotherapy to other sites within the past 2 weeks.
• Uncontrolled infection or serious infection within the past 4 weeks.
• Clinically significant non-malignant disease.
• Known HIV infection or AIDS-related illness.
• Myocardial infarction, stroke or congestive heart failure within the past 3 months.
• Current symptomatic central nervous system involvement, or active brain or meningeal metastases.
• Pregnancy, breast feeding, or women of childbearing potential in whom pregnancy cannot be excluded.
• History of abuse of alcohol, drugs, or other substances.
• History of acute or chronic gastrointestinal bleeding within the last two years, inflammatory bowel disease, any other abnormal bleeding tendency, or patients at risk of bleeding due to open wounds or planned surgery.
• Concomitant use of aspirin (more than 100 mg/day), non-steroidal anti-inflammatory drugs (except COX-2 Inhibitors), heparin, low molecular weight heparin or warfarin (more than 1 mg/day) is ongoing or anticipated during the study period. Low-dose aspirin (up to 100 mg/day) or low-dose warfarin (up to 1 mg/day) is permissible.
• Heparin or low molecular weight heparin within the previous 2 weeks.
• Not recovered from major surgery if conducted prior to the study.
• History of heparin-induced thrombocytopenia, immune mediated thrombocytopenia, thrombotic thrombocytopenic purpura or other platelet disease, or laboratory evidence of anti-heparin antibodies.

Sponsors & Collaborators

• Cellxpert Biotechnology Corp.: lead
• Medigen Biotechnology Corporation: collaborator

Study Sites (1)

University of Colorado Health Sciences Center

Aurora, Colorado, 80010-05801, United States

Location

MeSH Terms

Conditions

Melanoma

Interventions

phosphomannopentaose sulfate

Condition Hierarchy (Ancestors)

Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Nerve Tissue; Nevi and Melanomas; Skin Neoplasms; Neoplasms by Site; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: September 9, 2003
• First Posted: September 10, 2003
• Study Start: July 1, 2001
• Primary Completion: June 1, 2007
• Study Completion: June 1, 2007
• Last Updated: June 27, 2022

Record last verified: 2022-06

Locations

US (1)