Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements

NCT00063115 | Completed

• 2 other identifiers: 03023003-N-0230
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements. This study will look at how different areas of the human brain control fine hand movements. Thirty-five participants 21 years and older will be enrolled in this study-25 healthy, right-handed people, and 10 stroke patients. They will undergo two outpatient sessions, each lasting up to 3 hours. The first visit for the stroke patients will occur between 2 weeks and 3 months after the stroke; the second visit will be at least 6 months after the stroke. Participants will have a physical exam, give a medical history, and complete a questionnaire. Then they will undergo magnetic resonance imaging (MRI) scans. They will lie in the MRI scanner and will be asked to do a number of skilled hand movements using the right hand (such as pretending to use a hammer or waving goodbye) in response to directions that will appear on a screen mounted over their head. Their movements will be recorded on videotape during the procedures.

Conditions

Ideomotor Apraxia

Keywords

Praxis Movements; Pantomime; Statistical Parametric Mapping; Functional Connectivity; Path Analysis; Ideomotor Apraxia; Healthy Volunteer; HV

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy volunteers.
• Patients diagnosed with ideomotor apraxia with a single left hemisphere stroke will be included.
• The lesion will be located in any part of the frontal and parietal areas or both, as well as their connections.

You may not qualify if:

• Subjects with abnormal neurologic examinations, previous or current neurological and psychiatric disorders will be excluded.
• Subjects under age 21, pregnant or mentally impaired will also be excluded.
• Ideomotor apraxic patients with a second neurologic disorder including more than one brain lesion of the inability to cooperate fully will be excluded.
• Patients with a history of significant medical disorders such as cancers will be excluded.
• MRI experiments will not be performed in subjects or patients who have pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pumps, or shrapnel fragments.
• Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware. Subjects will be screened for these contraindications prior to the study.
• MRI experiments will not be performed on pregnant women.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Haaland KY, Harrington DL, Knight RT. Neural representations of skilled movement. Brain. 2000 Nov;123 ( Pt 11):2306-13. doi: 10.1093/brain/123.11.2306.

  PMID: 11050030 BACKGROUND

MeSH Terms

Conditions

Apraxia, Ideomotor

Condition Hierarchy (Ancestors)

Apraxias; Psychomotor Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 19, 2003
• First Posted: June 20, 2003
• Study Start: June 16, 2003
• Study Completion: July 2, 2008
• Last Updated: July 2, 2017

Record last verified: 2008-07-02

Locations

US (1)