EEG and EMG Analysis of Ideomotor Apraxia

NCT00024999 | Completed

• 2 other identifiers: 02001102-N-0011
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease. It will use electroencephalography (EEG) and electromyography (EMG) to compare brain function in normal subjects and in patients with-a disorder affecting patients with stroke and other brain lesions. These patients have problems with timing, sequence and spatial organization of certain types of movements. EEG measures the electrical activity of the brain. The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head. EMG measures electrical activity from muscles. It uses wire electrodes placed on the skin over the muscles. Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study. Study participants will be asked to make certain movements with their arms or hands, such as waving and using scissors. Brain and muscle activity will be measured during these tasks with EEG and EMG recordings. Patients may be asked to repeat these tests over time as their condition changes (such as during recovery from a stroke) to gain information about the recovery process.

Conditions

Ideomotor Apraxia

Keywords

Movement; Coordination; Correlation; Coherence; Parietofrontal Circuitry; Apraxia; Ideomotor Apraxia; Healthy Volunteer; HV; Normal Control

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Normal subjects.
• Patients diagnosed with Ideomotor apraxia with a single left hemisphere lesion.
• Patients with Ideomotor apraxia with corticobasal ganglionic degeneration.

You may not qualify if:

• Normal subjects: abnormal neurologic examination or history of neurologic disorders.
• Ideomotor apraxic patients: a second neurologic disorder including more than one brain lesion or the inability to cooperate fully.
• Normal and Ideomotor apraxic patients: cognitively impaired subjects will not be accrued (for the purposes of this study, patients that can provide full informed consent for the study are not considered cognitively impaired).
• For MRI studies, patients with metallic implants to remove potential risks from this procedure.
• For MRI purposes, women who are pregnant are excluded from this part of the protocol. Therefore, all women of childbearing potential will have a pregnancy test performed, which must be negative, before proceeding.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Bannur U, Rajshekhar V. Post operative supplementary motor area syndrome: clinical features and outcome. Br J Neurosurg. 2000 Jun;14(3):204-10. doi: 10.1080/026886900408379.

  PMID: 10912196 BACKGROUND

MeSH Terms

Conditions

Apraxia, Ideomotor; Apraxias

Condition Hierarchy (Ancestors)

Psychomotor Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: October 10, 2001
• First Posted: October 11, 2001
• Study Start: October 1, 2001
• Study Completion: September 1, 2005
• Last Updated: March 4, 2008

Record last verified: 2005-09

Locations

US (1)