Esophageal Motility and Airway Defenses Among Infants

NCT00062452 | Completed DMC

• 2 other identifiers: EMADAI (completed)R03DK061502
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Feeding difficulties and airway related consequences contribute significantly to the infant mortality and morbidity. Some of these problems may be dependent on neural control and muscular function. Prematurity, congenital anomalies and perinatal depression represent three important conditions in infants, that may have feeding and airway difficulties.Development of motility of the foregut and the adaptation during normal and disease in developing infants is unclear.

Conditions

Infant, Premature, Diseases; Congenital Abnormalities; Perinatal Asphyxia

Keywords

Esophageal; Airway

Study Arms (1)

A-1,2,3

The cohort (A) comprised of high risk infants. There were 3 sub groups studied within this cohort: (1) premature infants, (2) Infants with congenital gut anomalies, and (3) perinatal asphyxia.

Eligibility Criteria

• Age: 2 Weeks - 6 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Premature infants congenital foregut anomalies Perinatal asphyxia

You may qualify if:

• Prematurely born infants, Infants with congenital foregut anomalies, Infants with perinatal asphyxia, Ability to maintain vital signs at study,

You may not qualify if:

• No contraindication to enteral feeding

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead
• Children's National Research Institute: collaborator

Study Sites (1)

Columbus Childrens Hospital

Columbus, Ohio, 43205, United States

Location

Related Publications (6)

• Jadcherla SR, Duong HQ, Hoffmann RG, Shaker R. Esophageal body and upper esophageal sphincter motor responses to esophageal provocation during maturation in preterm newborns. J Pediatr. 2003 Jul;143(1):31-8. doi: 10.1016/S0022-3476(03)00242-7.

  PMID: 12915821 RESULT

• Jadcherla SR, Hoffmann RG, Shaker R. Effect of maturation of the magnitude of mechanosensitive and chemosensitive reflexes in the premature human esophagus. J Pediatr. 2006 Jul;149(1):77-82. doi: 10.1016/j.jpeds.2006.02.041.

  PMID: 16860132 RESULT

• Jadcherla SR, Gupta A, Stoner E, Coley BD, Wiet GJ, Shaker R. Correlation of glottal closure using concurrent ultrasonography and nasolaryngoscopy in children: a novel approach to evaluate glottal status. Dysphagia. 2006 Jan;21(1):75-81. doi: 10.1007/s00455-005-9002-7.

  PMID: 16786412 RESULT

• Jadcherla SR. Manometric evaluation of esophageal-protective reflexes in infants and children. Am J Med. 2003 Aug 18;115 Suppl 3A:157S-160S. doi: 10.1016/s0002-9343(03)00215-8.

  PMID: 12928093 RESULT

• Jadcherla SR, Duong HQ, Hofmann C, Hoffmann R, Shaker R. Characteristics of upper oesophageal sphincter and oesophageal body during maturation in healthy human neonates compared with adults. Neurogastroenterol Motil. 2005 Oct;17(5):663-70. doi: 10.1111/j.1365-2982.2005.00706.x.

  PMID: 16185304 RESULT

• Gupta A, Jadcherla SR. The relationship between somatic growth and in vivo esophageal segmental and sphincteric growth in human neonates. J Pediatr Gastroenterol Nutr. 2006 Jul;43(1):35-41. doi: 10.1097/01.mpg.0000226368.24332.50.

  PMID: 16819375 RESULT

MeSH Terms

Conditions

Infant, Premature, Diseases; Congenital Abnormalities

Condition Hierarchy (Ancestors)

Infant, Newborn, Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Sudarshan R Jadcherla, MD

  Nationwide Children's Hospital/The Ohio State University College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 5, 2003
• First Posted: June 6, 2003
• Study Start: May 1, 2002
• Primary Completion: April 1, 2005
• Study Completion: July 1, 2005
• Last Updated: October 6, 2017

Record last verified: 2010-01

Locations

US (1)