A Safety, Tolerability and Efficacy Study of E7070 in Patients With Renal Cell Carcinoma

NCT00059735 | Completed Phase 2

• 1 other identifier: E7070-A001-206
• Study Type: interventional
• Target: 30
• Locations: 2 countries
• Sites: 5

Brief Summary

The purpose of this study is to determine if E7070 is a safe and effective treatment for cancer of the kidneys.

Conditions

Kidney Neoplasms; Carcinoma, Renal Cell; Adenocarcinoma, Renal Cell

Keywords

kidney cancer; kidney neoplasms; renal cell cancer

Interventions

E7070 DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>=18 years old.
• Have histologically/cytologically confirmed clear cell RCC.
• Previously untreated or one prior treatment with immunotherapy (one prior treatment may be represented by single agent interferon, single agent interleukin-2 or a combination of interferon with interleukin-2 with or without accompanying hematological growth factors).
• Documented evidence of progressive disease in the previous 3 months. In the absence of radiographic studies, patients may be entered on the study if they have clinical evidence of progressive disease.
• Have at least one unidimensional measurable lesion of RCC according to the RECIST guidelines. The following will not qualify as measurable lesions: bone, leptomeningeal disease, ascites, pleural/pericardial effusion, lymphangitis cutis/pulmonis, abdominal masses that are not confirmed and followed by imaging techniques, and cystic lesions.
• Be ambulatory and have a Karnofsky performance status \>=70%.
• Have a life expectancy of at least 3 months.
• Give written informed consent prior to any study-specific screening procedures, with the understanding that the consent may be withdrawn by the patient at any time without prejudice.
• Be willing and able to comply with the study protocol for the duration of the study.

You may not qualify if:

• Woman who are pregnant or breastfeeding. Women of childbearing potential with either a positive pregnancy test at screening or no pregnancy test. Women of childbearing potential unless (1) surgically sterile or (2) using adequate contraceptive measures (postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential).
• Fertile male subjects not willing to use contraception and whose female partners are not under adequate contraceptive protection.
• Known CNS metastases (if clinical suspicion of CNS metastases exists appropriate imaging must be performed prior to study entry).
• Prior treatment with chemotherapy (there is no restriction on prior epidermal growth factor directed therapy).
• Severe and uncontrolled cardiac or cardiovascular abnormalities.
• Severe uncontrolled intercurrent infections.
• Subjects with organ allografts.
• Any of the following abnormal screening hematological values: Hemoglobin (Hb) \<9g /dL (6 mmol/L), Neutrophils \<1.5 x 10\^9/L, Platelets \<100 x 10\^9/L.
• Blood transfusions or growth factors to aid hematological recovery within 2 weeks prior to starting study treatment.
• Any of the following abnormal screening liver function tests: serum bilirubin \>= 1.5 x upper normal limit (ULN), alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) \>= 2.5 x ULN (unless related to liver metastases in which case \>= 5 x ULN).
• The following abnormal screening renal function tests: either a serum creatinine \> 1.5 x ULN or a creatinine clearance (estimated from serum creatinine) \< 40 mL/minute.
• Prior radiotherapy (except palliative).
• Participation in any investigational drug study or immunotherapy within 4 weeks preceding treatment start.
• History of hypersensitivity to sulphonamides.
• Any concurrent or previous malignancy of a different tumor type within 5 years of starting E7070 treatment except for adequately treated non-melanoma skin cancer or cervical intra-epithelial neoplasia.

Sponsors & Collaborators

• Eisai Inc.: lead

Study Sites (5)

Unknown Facility

Sacramento, California, 95817, United States

Location

Unknown Facility

New York, New York, 10021, United States

Location

Unknown Facility

New York, New York, 10032, United States

Location

Unknown Facility

The Bronx, New York, 10466, United States

Location

Unknown Facility

Villejuif, 94805, France

Location

Related Links

• Related Info

MeSH Terms

Conditions

Kidney Neoplasms; Carcinoma, Renal Cell

Interventions

N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Study Officials

• Murray Yule, MRCP, PhD

  Eisai Limited

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: May 5, 2003
• First Posted: May 7, 2003
• Study Start: May 1, 2002
• Study Completion: December 1, 2003
• Last Updated: March 5, 2008

Record last verified: 2008-02

Locations

US (4); FR (1)