Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 40/100

Failure Rate

14.9%

79 terminated/withdrawn out of 531 trials

Success Rate

83.4%

-3.1% vs industry average

Late-Stage Pipeline

26%

138 trials in Phase 3/4

Results Transparency

65%

258 of 398 completed trials have results

Key Signals

11 recruiting258 with results63 terminated16 withdrawn

Enrollment Performance

Analytics

Phase 2
176(35.3%)
Phase 1
175(35.1%)
Phase 3
97(19.4%)
Phase 4
41(8.2%)
N/A
7(1.4%)
Early Phase 1
3(0.6%)
499Total
Phase 2(176)
Phase 1(175)
Phase 3(97)
Phase 4(41)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (531)

Showing 20 of 531 trials
NCT04736706Phase 3Active Not Recruiting

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Role: collaborator

NCT07849660Active Not Recruiting

Real-World Lenvatinib Sequencing in Unresectable Hepatocellular Carcinoma (uHCC)

Role: lead

NCT07840638Phase 4Not Yet Recruiting

How Well and Safely Does Lemborexant Work for People Who Wake up at Night to Urinate (LENS)

Role: collaborator

NCT07723950Active Not Recruiting

A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease

Role: lead

NCT07821658Recruiting

A Postmarketing Study of Lecanemab for the Treatment of Participants With Alzheimer's Disease

Role: lead

NCT04246177Phase 3Terminated

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Role: collaborator

NCT03331250Phase 2Completed

Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE)

Role: collaborator

NCT04288089Phase 1Active Not Recruiting

A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

Role: lead

NCT04949256Phase 3Terminated

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014).

Role: collaborator

NCT07308236Phase 1Completed

A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants

Role: lead

NCT05899049Phase 3Active Not Recruiting

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Role: collaborator

NCT07768592Phase 1Not Yet Recruiting

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2511 in Participants With Early Alzheimer's Disease (AD)

Role: lead

NCT07766369Phase 1Not Yet Recruiting

A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants

Role: lead

NCT05308901Phase 2Terminated

Lenvatinib Plus Pembrolizumab In Patients With Immune Checkpoint Inhibitor Naïve Metastatic Uveal Melanoma

Role: collaborator

NCT06854042Phase 1Active Not Recruiting

A Study of Oral E1018 in Healthy Adult Participants

Role: lead

NCT05619913Phase 2Completed

EPOCH: Eribulin and Pembrolizumab in Ovarian/Uterine Carcinosarcoma

Role: collaborator

NCT01760005Phase 2Active Not Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Role: collaborator

NCT06384573Phase 3Active Not Recruiting

DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease

Role: collaborator

NCT05269394Phase 2Active Not Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Role: collaborator

NCT06274528Phase 2Recruiting

DORA and LP in Alzheimer's Disease Biomarkers

Role: collaborator