Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 40/100

Failure Rate

14.5%

76 terminated/withdrawn out of 525 trials

Success Rate

83.8%

-2.7% vs industry average

Late-Stage Pipeline

26%

137 trials in Phase 3/4

Results Transparency

65%

255 of 394 completed trials have results

Key Signals

13 recruiting255 with results60 terminated16 withdrawn

Enrollment Performance

Analytics

Phase 2
175(35.3%)
Phase 1
173(34.9%)
Phase 3
97(19.6%)
Phase 4
40(8.1%)
N/A
7(1.4%)
Early Phase 1
4(0.8%)
496Total
Phase 2(175)
Phase 1(173)
Phase 3(97)
Phase 4(40)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (525)

Showing 20 of 525 trials
NCT04736706Phase 3Active Not Recruiting

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Role: collaborator

NCT06274528Phase 2Recruiting

DORA and LP in Alzheimer's Disease Biomarkers

Role: collaborator

NCT04586231Phase 3Active Not Recruiting

A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

Role: collaborator

NCT04199104Phase 3Completed

A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)

Role: collaborator

NCT03797326Phase 2Completed

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

Role: collaborator

NCT05613088Phase 2Completed

A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Role: collaborator

NCT04662710Phase 3Completed

Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)

Role: collaborator

NCT04246177Phase 3Completed

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Role: collaborator

NCT05064280Phase 2Recruiting

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

Role: collaborator

NCT04645602Early Phase 1Recruiting

Merck IIT: RRP Pembro and Lenvatinib

Role: collaborator

NCT03361436Phase 1Active Not Recruiting

Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

Role: collaborator

NCT07493265Phase 2Not Yet Recruiting

A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy

Role: lead

NCT04008797Phase 1Active Not Recruiting

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

Role: lead

NCT06188559Phase 2Active Not Recruiting

A Study of BB-1701 in Previously Treated Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive or HER2-low Unresectable or Metastatic Breast Cancer

Role: lead

NCT03517449Phase 3Completed

Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775])

Role: lead

NCT05523323Phase 3Completed

A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension

Role: collaborator

NCT04468659Phase 3Active Not Recruiting

AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

Role: lead

NCT04300556Phase 1Recruiting

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

Role: lead

NCT03264664Phase 1Active Not Recruiting

Study of E7386 in Participants With Selected Advanced Neoplasms

Role: lead

NCT07308236Phase 1Recruiting

A Study to Determine the Metabolism and Excretion of [14C]E2086 in Healthy Male Participants

Role: lead