Brain Irradiation in Treating Patients With Limited-Stage Small Cell Lung Cancer
A Phase II Randomized Trial Of Two Dose Schedules For Delivering Prophylactic Cranial Irradiation For Patients With Limited Disease Small Cell Lung Cancer
2 other identifiers
interventional
265
2 countries
222
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective in preventing brain metastases in patients with limited-stage small cell lung cancer while taking into account chronic neurotoxicity from radiation therapy. PURPOSE: This randomized phase II trial compares the incidence of chronic neurotoxicity between three different brain irradiation regimens. The corresponding phase III component addressing the prevention of brain metastases was run by EORTC and reported separately (NCT00005062).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2 lung-cancer
Started Feb 2003
Longer than P75 for phase_2 lung-cancer
222 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2003
CompletedFirst Submitted
Initial submission to the registry
April 7, 2003
CompletedFirst Posted
Study publicly available on registry
April 9, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2013
CompletedResults Posted
Study results publicly available
May 25, 2016
CompletedMay 25, 2016
April 1, 2016
6.2 years
April 7, 2003
April 18, 2016
April 18, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of Chronic Neurotoxicity
Chronic neurotoxicity is defined as a drop in one standard error of measurement (SEM) in any one of the three tests comprising the neuropsychological test battery (Hopkins Verbal Learning Test, Controlled Word Association Test, and Trail-Making Test) without development of brain metastasis by one year. The SEM is calculated as the standard deviation of the baseline test multiplied by the square root of one minus the published reliability coefficient for the test.
From study registration to one year.
Study Arms (3)
Arm I
ACTIVE COMPARATORProphylactic cranial irradiation, 2.5 Gy fx
Arm II
EXPERIMENTALProphylactic cranial irradiation, 2.0 Gy fx
Arm III
EXPERIMENTALProphylactic cranial irradiation, 1.5 Gy fx
Interventions
Prophylactic cranial irradiation, 2.5 Gy once daily, M-F, in 10 fractions (fx) for a total of 25 Gy
Prophylactic cranial irradiation, 2.0 Gy once daily, M-F, in 18 fractions (fx) for a total of 36 Gy
Prophylactic cranial irradiation, 1.5 Gy twice daily, M-F, in 24 fractions (fx) for a total dose of 36 Gy
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- Radiation Therapy Oncology Grouplead
- National Cancer Institute (NCI)collaborator
Study Sites (222)
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham
Birmingham, Alabama, 35294, United States
Arizona Oncology Services Foundation
Phoenix, Arizona, 85013, United States
Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn
Scottsdale, Arizona, 85251, United States
Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea
Scottsdale, Arizona, 85260, United States
Highlands Oncology Group - Springdale
Springdale, Arkansas, 72764, United States
Auburn Radiation Oncology
Auburn, California, 95603, United States
Radiation Oncology Centers - Cameron Park
Cameron Park, California, 95682, United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658, United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609, United States
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
Pomona, California, 91767, United States
Radiation Oncology Center - Roseville
Roseville, California, 95661, United States
Radiological Associates of Sacramento Medical Group, Incorporated
Sacramento, California, 95815, United States
Mercy General Hospital
Sacramento, California, 95819, United States
Solano Radiation Oncology Center
Vacaville, California, 95687, United States
Memorial Hospital Cancer Center - Colorado Springs
Colorado Springs, Colorado, 80909, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, 81502, United States
Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, 19958, United States
CCOP - Christiana Care Health Services
Newark, Delaware, 19713, United States
University of Florida Shands Cancer Center
Gainesville, Florida, 32610-0232, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami
Miami, Florida, 33136, United States
Baptist-South Miami Regional Cancer Program
Miami, Florida, 33176, United States
Bay Medical
Panama City, Florida, 32401, United States
Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
Northwest Community Hospital
Arlington Heights, Illinois, 60005, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60507, United States
St. Joseph Medical Center
Bloomington, Illinois, 61701, United States
Graham Hospital
Canton, Illinois, 61520, United States
Memorial Hospital
Carthage, Illinois, 62321, United States
St. Anthony's Memorial Hospital
Effingham, Illinois, 62401, United States
Eureka Community Hospital
Eureka, Illinois, 61530, United States
Galesburg Clinic, PC
Galesburg, Illinois, 61401, United States
Galesburg Cottage Hospital
Galesburg, Illinois, 61401, United States
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, 61401, United States
Mason District Hospital
Havana, Illinois, 62644, United States
Hopedale Medical Complex
Hopedale, Illinois, 61747, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
Kewanee Hospital
Kewanee, Illinois, 61443, United States
La Grange Memorial Hospital
La Grange, Illinois, 60525, United States
McDonough District Hospital
Macomb, Illinois, 61455, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153, United States
BroMenn Regional Medical Center
Normal, Illinois, 61761, United States
Community Cancer Center
Normal, Illinois, 61761, United States
Community Hospital of Ottawa
Ottawa, Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, 61554, United States
Proctor Hospital
Peoria, Illinois, 61614, United States
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61615, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria, Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
OSF St. Francis Medical Center
Peoria, Illinois, 61637, United States
Illinois Valley Community Hospital
Peru, Illinois, 61354, United States
Perry Memorial Hospital
Princeton, Illinois, 61356, United States
St. Margaret's Hospital
Spring Valley, Illinois, 61362, United States
Valley Cancer Center
Spring Valley, Illinois, 61362, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
Saint John's Cancer Center at Saint John's Medical Center
Anderson, Indiana, 46016, United States
Parkview Regional Cancer Center at Parkview Health
Fort Wayne, Indiana, 46805, United States
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202-5289, United States
Veterans Affairs Medical Center - Indianapolis
Indianapolis, Indiana, 46202, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Cancer Center at Ball Memorial Hospital
Muncie, Indiana, 47303-3499, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
McFarland Clinic, PC
Ames, Iowa, 50010, United States
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1002, United States
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042, United States
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068, United States
Southwest Medical Center
Liberal, Kansas, 67901, United States
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67042, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, 66606, United States
St. Francis Comprehensive Cancer Center
Topeka, Kansas, 66606, United States
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67203, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156, United States
Lucille P. Markey Cancer Center at University of Kentucky
Lexington, Kentucky, 40536-0093, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
Union Hospital Cancer Program at Union Hospital
Elkton MD, Maryland, 21921, United States
Boston University Cancer Research Center
Boston, Massachusetts, 02118, United States
Hudner Oncology Center at Saint Anne's Hospital - Fall River
Fall River, Massachusetts, 02721, United States
South Suburban Oncology Center
Quincy, Massachusetts, 02169, United States
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221, United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0942, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, 49017, United States
Mecosta County Medical Center
Big Rapids, Michigan, 49307, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, 49503, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Health Care
Grand Rapids, Michigan, 49503, United States
Metro Health Hospital
Grand Rapids, Michigan, 49506, United States
Holland Community Hospital
Holland, Michigan, 49423, United States
Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
Hackley Hospital
Muskegon, Michigan, 49442, United States
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph, Michigan, 49085, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Immanuel St. Joseph's
Mankato, Minnesota, 56002, United States
CentraCare Clinic - River Campus
Saint Cloud, Minnesota, 56303, United States
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, 39581, United States
Cancer Institute of Cape Girardeau, LLC
Cape Girardeau, Missouri, 63703, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
Radiation Oncology Associates - Reno
Reno, Nevada, 89509, United States
Ocean Medical Center at Meridian Health
Brick, New Jersey, 08724, United States
John F. Kennedy Medical Center
Edison, New Jersey, 08818, United States
Monmouth Medical Center
Long Branch, New Jersey, 07740-6395, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Marlton, New Jersey, 08053, United States
Booker Cancer Center at Riverview Medical Center
Red Bank, New Jersey, 07701, United States
Frederick R. and Betty M. Smith Cancer Treatment Center
Sparta, New Jersey, 07871, United States
J. Phillip Citta Regional Cancer Center at Community Medical Center
Toms River, New Jersey, 08755, United States
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
Vineland, New Jersey, 08360, United States
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees Township, New Jersey, 08043, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001, United States
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown, New York, 10940-4199, United States
Hudson Valley Oncology Associates
Poughkeepsie, New York, 12601, United States
Highland Hospital of Rochester
Rochester, New York, 14620, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
SUNY Upstate Medical University Hospital
Syracuse, New York, 13210, United States
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, 28233-3549, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Wayne Radiation Oncology
Goldsboro, North Carolina, 27534, United States
Leo W. Jenkins Cancer Center at ECU Medical School
Greenville, North Carolina, 27835-6028, United States
Kinston Medical Specialists
Kinston, North Carolina, 28501, United States
Iredell Memorial Hospital
Statesville, North Carolina, 28677, United States
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, 44309-2090, United States
Aultman Cancer Center at Aultman Hospital
Canton, Ohio, 44710-1799, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267, United States
Huron Hospital Cancer Care Center
Cleveland, Ohio, 44112, United States
Euclid Hospital
Cleveland, Ohio, 44119, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
MedCentral - Mansfield Hospital
Mansfield, Ohio, 44903, United States
St. Luke's Hospital
Maumee, Ohio, 43537, United States
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights, Ohio, 44124, United States
St. Charles Mercy Hospital
Oregon, Ohio, 43616, United States
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
Salem, Ohio, 44460, United States
Firelands Regional Medical Center
Sandusky, Ohio, 44870, United States
Flower Hospital Cancer Center
Sylvania, Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623, United States
South Pointe Hospital Cancer Care Center
Warrensville Heights, Ohio, 44122, United States
Cancer Treatment Center
Wooster, Ohio, 44691, United States
Three Rivers Community Hospital
Grants Pass, Oregon, 97527, United States
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030, United States
Dubs Cancer Center at Rogue Valley Medical Center
Medford, Oregon, 97504, United States
Providence Cancer Center at PMCC
Medford, Oregon, 97504, United States
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222, United States
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland, Oregon, 97210, United States
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213-2967, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Legacy Emanuel Hospital and Health Center and Children's Hospital
Portland, Oregon, 97227, United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062, United States
Rosenfeld Cancer Center at Abington Memorial Hospital
Abington, Pennsylvania, 19001, United States
St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem, Pennsylvania, 18015, United States
Dale and Frances Hughes Cancer Center at Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107-5541, United States
Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, 19111-2497, United States
Fox Chase Cancer Center CCOP Research Base
Philadelphia, Pennsylvania, 19140, United States
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, 19141, United States
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052, United States
York Cancer Center at Apple Hill Medical Center
York, Pennsylvania, 17405, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57701, United States
Arlington Cancer Center - Arlington
Arlington, Texas, 76012-2510, United States
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390, United States
M. D. Anderson Cancer Center at University of Texas
Houston, Texas, 77030-4009, United States
Cottonwood Hospital Medical Center
Murray, Utah, 84107, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
Murray, Utah, 84157, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604, United States
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, 84106, United States
LDS Hospital
Salt Lake City, Utah, 84143, United States
Dixie Regional Medical Center - East Campus
St. George, Utah, 84770, United States
St. Joseph Cancer Center
Bellingham, Washington, 98225, United States
Harrison Medical Center
Bremerton, Washington, 98310, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98104, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98122-4307, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195-6043, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Madigan Army Medical Center - Tacoma
Tacoma, Washington, 98431, United States
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98668, United States
Wenatchee Valley Medical Center
Wenatchee, Washington, 98801-2028, United States
Schiffler Cancer Center at Wheeling Hospital
Wheeling, West Virginia, 26003, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54301-3526, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303, United States
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, 53226, United States
Veterans Affairs Medical Center - Milwaukee
Milwaukee, Wisconsin, 53295, United States
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066, United States
All Saints Cancer Center at Wheaton Franciscan Healthcare
Racine, Wisconsin, 53405, United States
Waukesha Memorial Hospital Regional Cancer Center
Waukesha, Wisconsin, 53188, United States
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
Hopital Notre-Dame du CHUM
Montreal, Quebec, H2L 4M1, Canada
Centre Hospitalier Universitaire de Quebec
Québec, Quebec, G1R 2J6, Canada
McGill Cancer Centre at McGill University
Montreal, H2W 1S6, Canada
Related Publications (4)
Gondi V, Paulus R, Bruner D, et al.: Prognostic significance of QOL deterioration during early lung cancer survivorship: secondary analysis of RTOG 0212 and 0214. [Abstract] J Clin Oncol 29 (Suppl 15): A-6061, 2011.
BACKGROUNDLe Pechoux C, Dunant A, Senan S, Wolfson A, Quoix E, Faivre-Finn C, Ciuleanu T, Arriagada R, Jones R, Wanders R, Lerouge D, Laplanche A; Prophylactic Cranial Irradiation (PCI) Collaborative Group. Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial. Lancet Oncol. 2009 May;10(5):467-74. doi: 10.1016/S1470-2045(09)70101-9. Epub 2009 Apr 20.
PMID: 19386548BACKGROUNDPechoux CL, Hatton M, Kobierska A, et al.: Randomized trial of standard dose to a higher dose prophylactic cranial irradiation (PCI) in limited-stage small cell cancer (SCLC) complete responders (CR): primary endpoint analysis (PCI99-01, IFCT 99-01, EORTC 22003-08004, RTOG 0212). [Abstract] J Clin Oncol 26 (Suppl 15): A-LBA7514, 2008.
BACKGROUNDWolfson AH, Bae K, Komaki R, Meyers C, Movsas B, Le Pechoux C, Werner-Wasik M, Videtic GM, Garces YI, Choy H. Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):77-84. doi: 10.1016/j.ijrobp.2010.05.013. Epub 2010 Aug 26.
PMID: 20800380RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Limitations and Caveats
The number of inevaluable patients at one year (e.g., patients dying prior to 1 year, patients not completing the neurocognitive battery at 1 year) was greater than anticipated.
Results Point of Contact
- Title
- Wendy Seiferheld
- Organization
- NRG Onoclogy
Study Officials
- STUDY CHAIR
Aaron H. Wolfson, MD
University of Miami Sylvester Comprehensive Cancer Center
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 7, 2003
First Posted
April 9, 2003
Study Start
February 1, 2003
Primary Completion
May 1, 2009
Study Completion
November 1, 2013
Last Updated
May 25, 2016
Results First Posted
May 25, 2016
Record last verified: 2016-04