"REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
REDUCE
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Dutasteride 0.5 mg Administered Orally Once Daily for Four Years to Reduce the Risk of Biopsy-Detectable Prostate Cancer
1 other identifier
interventional
8,231
37 countries
865
Brief Summary
This 4-year study will compare how safe and effective an oral investigational medicine is (compared to placebo) in preventing the development of prostate cancer in men that are defined by the study entrance criteria as being at an increased risk for prostate cancer. Study visits to the clinic will occur every 6 months for up to 4 years (10 clinic visits), and a prostate biopsy will be performed at 2 and 4 years of treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 2003
Longer than P75 for phase_3
865 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2003
CompletedFirst Submitted
Initial submission to the registry
March 11, 2003
CompletedFirst Posted
Study publicly available on registry
March 13, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2009
CompletedResults Posted
Study results publicly available
March 5, 2010
CompletedSeptember 23, 2016
August 1, 2016
5.8 years
March 11, 2003
February 1, 2010
August 17, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Number of Participants With Biopsy-detectable Prostate Cancer at Years 2 and 4 (Crude Rate Approach)
Study biopsies consisted of 10 biopsy samples (cores) in a pre-defined pattern. Biopsies were read at the central pathology laboratory (CPL, which processed the majority, 94%, of biopsies). Biopsy cases that were positive for prostate cancer or precancerous lesions (high-grade prostatic intraepithelial neoplasia\[HGPIN\] or typical small acinar proliferation \[ASAP\]) and prostate surgeries were reviewed by the lead pathologist.
Years 1-2, Years 3-4, and Overall (Years 1-4)
Number of Participants With Biopsy-detectable Prostate Cancer at Years 2 and 4 (Modified Crude Rate Approach)
Study biopsies (biop.) consisted of 10 biop. samples (cores) in a pre-defined pattern and were read at the central pathology laboratory. Biop. cases that were positive for prostate cancer or precancerous lesions (HGPIN or ASAP) and prostate surgeries were reviewed by the lead pathologist. Participants included in the risk sets at Years 1-2 and Years 3-4 included those with a positive biop. at Years 1-2 or a biop. after Months 18-24, and those with a positive biop. at Years 3-4 or a biop. after Month 42, respectively. Overall included participants with a positive biop. or biop. after Month 42.
Years 1-2, Years 3-4, and Overall (Years 1-4)
Number of Participants With Biopsy-detectable Prostate Cancer at Years 2 and 4 (Restricted Crude Rate Approach)
Study biopsies consisted of 10 biopsy samples (cores) in a pre-defined pattern. Biopsies were read at the central pathology laboratory (which processed the majority, 94%, of biopsies). Biopsy cases that were positive for prostate cancer or precancerous lesions (HGPIN or ASAP) and prostate surgeries were reviewed by the lead pathologist. Participants included in the risk set at Years 1-2, Years 3-4, and Overall (Years 1-4) were those who had a biopsy during the specified time period.
Years 1-2, Years 3-4, and Overall (Years 1-4)
Secondary Outcomes (23)
Number of Participants With the Indicated Gleason Score at Diagnosis
Baseline to Year 4
Number of Participants With HGPIN, ASAP, and Prostate Cancer at Biopsy
Baseline to Year 4
Volume of HGPIN at Biopsy
Baseline to Year 4
Percentage of Core Involved at Diagnosis
Baseline to Year 4
Number of Cancer-positive Cores
Baseline to Year 4
- +18 more secondary outcomes
Study Arms (2)
Placebo Arm
PLACEBO COMPARATOREligible subjects will complete a 4-week placebo run-in followed by randomization to matched placebo in a 1:1 ratio.
dustasteride arm
EXPERIMENTALEligible subjects will complete a 4-week placebo run-in followed by randomization to 0.5mg dutasteride in a 1:1 ratio. Randomization will be stratified by center.
Interventions
After successful completion of the placebo run-in phase, subjects who continue to meet eligibility requirements will be randomized into the double-blind phase of the study and issued a 6-month supply of study drug. Subjects will self-administer study drug once daily dosing of 0.5mg of dutasteride orally for up to 4 years.
After successful completion of the placebo run-in phase, subjects who continue to meet eligibility requirements will be randomized into the double-blind phase of the study and issued a 6-month supply of study drug. Subjects will self-administer study drug once daily orally for up to 4 years.
Eligibility Criteria
You may qualify if:
- Informed consent to participate in study.
- Have had a single negative prostate biopsy within 6 months prior to enrollment in study.
- Have a PSA (prostate specific antigen) between 2.5 and 10 if 50-60 years of age; or a PSA between 3.0 and 10 if over age 60.
- Ability and will to participate in study for 4 years.
You may not qualify if:
- More than one previous negative prostate biopsy.
- History of prostate cancer.
- Previous prostate surgery.
- Inability to urinate requiring the need of a catheter during the previous 2 years.
- Any condition (other than benign prostatic hypertrophy) which may result in urinary symptoms or changes in urine flow rate.
- Cancer within previous 5 years (other than basal or squamous cell cancers of the skin).
- Any unstable serious medical condition.
- Use within the past 12 months of finasteride (Proscar or Propecia), dutasteride (Avodart), testosterone, or drugs that can block the action of male hormones.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- GlaxoSmithKlinelead
Study Sites (932)
GSK Investigational Site
Birmingham, Alabama, 35209, United States
GSK Investigational Site
Homewood, Alabama, 35209, United States
GSK Investigational Site
Huntsville, Alabama, 35801, United States
GSK Investigational Site
Mobile, Alabama, 36608, United States
GSK Investigational Site
Anchorage, Alaska, 99508, United States
GSK Investigational Site
Phoenix, Arizona, 85014, United States
GSK Investigational Site
Phoenix, Arizona, 85023, United States
GSK Investigational Site
Phoenix, Arizona, 85032, United States
GSK Investigational Site
Scottsdale, Arizona, 85258, United States
GSK Investigational Site
Sun City, Arizona, 85375, United States
GSK Investigational Site
Tucson, Arizona, 85710, United States
GSK Investigational Site
Tucson, Arizona, 85712, United States
GSK Investigational Site
Little Rock, Arkansas, 72205, United States
GSK Investigational Site
Little Rock, Arkansas, 72211, United States
GSK Investigational Site
Anaheim, California, 92801, United States
GSK Investigational Site
Atherton, California, 94027, United States
GSK Investigational Site
Culver City, California, 90232, United States
GSK Investigational Site
Encino, California, 91316, United States
GSK Investigational Site
Fountain Valley, California, 92708, United States
GSK Investigational Site
Fresno, California, 93720, United States
GSK Investigational Site
Irvine, California, 92618, United States
GSK Investigational Site
La Mesa, California, 91942, United States
GSK Investigational Site
Laguna Hills, California, 92653, United States
GSK Investigational Site
Long Beach, California, 90806, United States
GSK Investigational Site
Los Angeles, California, 90024, United States
GSK Investigational Site
Los Angeles, California, 90033, United States
GSK Investigational Site
Los Angeles, California, 90048, United States
GSK Investigational Site
Los Angeles, California, 90059, United States
GSK Investigational Site
Los Angeles, California, 90073, United States
GSK Investigational Site
Mather, California, 95655, United States
GSK Investigational Site
Newport Beach, California, 92660, United States
GSK Investigational Site
Orange, California, 92869, United States
GSK Investigational Site
Pico Rivera, California, 90660, United States
GSK Investigational Site
Poway, California, 92064, United States
GSK Investigational Site
Sacramento, California, 95816, United States
GSK Investigational Site
Salinas, California, 93901, United States
GSK Investigational Site
San Bernardino, California, 92404, United States
GSK Investigational Site
San Diego, California, 92103-6204, United States
GSK Investigational Site
San Diego, California, 92103, United States
GSK Investigational Site
San Diego, California, 92120, United States
GSK Investigational Site
San Diego, California, 92128, United States
GSK Investigational Site
San Francisco, California, 94108, United States
GSK Investigational Site
San Francisco, California, 94121, United States
GSK Investigational Site
San Ramon, California, 94583, United States
GSK Investigational Site
Santa Monica, California, 90404, United States
GSK Investigational Site
Stanford, California, 94305, United States
GSK Investigational Site
Temecula, California, 92591, United States
GSK Investigational Site
Torrance, California, 90505, United States
GSK Investigational Site
Upland, California, 91786, United States
GSK Investigational Site
Van Nuys, California, 91405, United States
GSK Investigational Site
Walnut Creek, California, 94598, United States
GSK Investigational Site
Westchester, California, 90045, United States
GSK Investigational Site
Aurora, Colorado, 80010, United States
GSK Investigational Site
Aurora, Colorado, 80012, United States
GSK Investigational Site
Denver, Colorado, 80211, United States
GSK Investigational Site
Denver, Colorado, 80220, United States
GSK Investigational Site
Englewood, Colorado, 80113, United States
GSK Investigational Site
Longmont, Colorado, 80501, United States
GSK Investigational Site
Hartford, Connecticut, 06106, United States
GSK Investigational Site
Middlebury, Connecticut, 06762, United States
GSK Investigational Site
New Britain, Connecticut, 06052, United States
GSK Investigational Site
Trumbull, Connecticut, 06611, United States
GSK Investigational Site
Washington D.C., District of Columbia, 20307-5001, United States
GSK Investigational Site
Aventura, Florida, 33180, United States
GSK Investigational Site
Clearwater, Florida, 33756, United States
GSK Investigational Site
Clearwater, Florida, 33761, United States
GSK Investigational Site
Delray Beach, Florida, 33484, United States
GSK Investigational Site
Fort Myers, Florida, 33916, United States
GSK Investigational Site
Jacksonville, Florida, 32216, United States
GSK Investigational Site
Jacksonville, Florida, 32224, United States
GSK Investigational Site
Jacksonville, Florida, 32257, United States
GSK Investigational Site
Lake Worth, Florida, 33461, United States
GSK Investigational Site
Largo, Florida, 33773, United States
GSK Investigational Site
Longwood, Florida, 32750, United States
GSK Investigational Site
Margate, Florida, 33063, United States
GSK Investigational Site
Melbourne, Florida, 32901, United States
GSK Investigational Site
Miami, Florida, 33156, United States
GSK Investigational Site
New Port Richey, Florida, 34652, United States
GSK Investigational Site
Ocala, Florida, 34471, United States
GSK Investigational Site
Ocala, Florida, 34474, United States
GSK Investigational Site
Okeechobee, Florida, 34972, United States
GSK Investigational Site
Orange Park, Florida, 32073, United States
GSK Investigational Site
Orlando, Florida, 32803, United States
GSK Investigational Site
Panama City, Florida, 32405, United States
GSK Investigational Site
Plantation, Florida, 33317, United States
GSK Investigational Site
Sarasota, Florida, 34237, United States
GSK Investigational Site
South Daytona, Florida, 32119, United States
GSK Investigational Site
St. Petersburg, Florida, 33703, United States
GSK Investigational Site
Stuart, Florida, 34996, United States
GSK Investigational Site
Tallahassee, Florida, 32308, United States
GSK Investigational Site
Tamarac, Florida, 33321, United States
GSK Investigational Site
West Palm Beach, Florida, 33409, United States
GSK Investigational Site
Atlanta, Georgia, 30308, United States
GSK Investigational Site
Atlanta, Georgia, 30309, United States
GSK Investigational Site
Atlanta, Georgia, 30342, United States
GSK Investigational Site
Augusta, Georgia, 30912, United States
GSK Investigational Site
Fayetteville, Georgia, 30214, United States
GSK Investigational Site
Marietta, Georgia, 30060, United States
GSK Investigational Site
Roswell, Georgia, 30076, United States
GSK Investigational Site
Woodstock, Georgia, 30189, United States
GSK Investigational Site
Honolulu, Hawaii, 96813, United States
GSK Investigational Site
Coeur d'Alene, Idaho, 83814, United States
GSK Investigational Site
Chicago, Illinois, 60612, United States
GSK Investigational Site
Chicago, Illinois, 60616, United States
GSK Investigational Site
Chicago, Illinois, 60637, United States
GSK Investigational Site
Chicago, Illinois, 60640, United States
GSK Investigational Site
Galesburg, Illinois, 61401, United States
GSK Investigational Site
Kankakee, Illinois, 60901, United States
GSK Investigational Site
Maywood, Illinois, 60153, United States
GSK Investigational Site
Melrose Park, Illinois, 60160, United States
GSK Investigational Site
Niles, Illinois, 60714, United States
GSK Investigational Site
Springfield, Illinois, 62781, United States
GSK Investigational Site
Evansville, Indiana, 47714, United States
GSK Investigational Site
Fort Wayne, Indiana, 46825, United States
GSK Investigational Site
Indianapolis, Indiana, 46202, United States
GSK Investigational Site
Jeffersonville, Indiana, 47130, United States
GSK Investigational Site
Kansas City, Kansas, 66160, United States
GSK Investigational Site
Overland Park, Kansas, 66211, United States
GSK Investigational Site
Wichita, Kansas, 67208, United States
GSK Investigational Site
Lexington, Kentucky, 40508, United States
GSK Investigational Site
Covington, Louisiana, 70433, United States
GSK Investigational Site
Gretna, Louisiana, 70056, United States
GSK Investigational Site
Houma, Louisiana, 70360, United States
GSK Investigational Site
Lafayette, Louisiana, 70503, United States
GSK Investigational Site
Metairie, Louisiana, 70001, United States
GSK Investigational Site
New Orleans, Louisiana, 70115, United States
GSK Investigational Site
New Orleans, Louisiana, 70119, United States
GSK Investigational Site
New Orleans, Louisiana, 70121, United States
GSK Investigational Site
Ruston, Louisiana, 71270, United States
GSK Investigational Site
Shreveport, Louisiana, 71106, United States
GSK Investigational Site
Annapolis, Maryland, 21401, United States
GSK Investigational Site
Baltimore, Maryland, 21201, United States
GSK Investigational Site
Greenbelt, Maryland, 20770, United States
GSK Investigational Site
Owings Mills, Maryland, 21117, United States
GSK Investigational Site
Rockville, Maryland, 20850, United States
GSK Investigational Site
Towson, Maryland, 21204, United States
GSK Investigational Site
Boston, Massachusetts, 02115, United States
GSK Investigational Site
Braintree, Massachusetts, 02184, United States
GSK Investigational Site
Haverhill, Massachusetts, 01830, United States
GSK Investigational Site
Milford, Massachusetts, 01757, United States
GSK Investigational Site
Newton, Massachusetts, 2462, United States
GSK Investigational Site
Springfield, Massachusetts, 01107, United States
GSK Investigational Site
Waltham, Massachusetts, 02453, United States
GSK Investigational Site
Watertown, Massachusetts, 02472, United States
GSK Investigational Site
West Yarmouth, Massachusetts, 02673, United States
GSK Investigational Site
Wocester, Massachusetts, 01608, United States
GSK Investigational Site
Ann Arbor, Michigan, 48106, United States
GSK Investigational Site
Detroit, Michigan, 48202, United States
GSK Investigational Site
Royal Oak, Michigan, 48073, United States
GSK Investigational Site
Saint Joseph, Michigan, 49085, United States
GSK Investigational Site
Chaska, Minnesota, 55318, United States
GSK Investigational Site
Edina, Minnesota, 55435, United States
GSK Investigational Site
Minneapolis, Minnesota, 55404, United States
GSK Investigational Site
Rochester, Minnesota, 55905, United States
GSK Investigational Site
Saint Cloud, Minnesota, 56303, United States
GSK Investigational Site
Hattiesburg, Mississippi, 39401, United States
GSK Investigational Site
Jackson, Mississippi, 39202, United States
GSK Investigational Site
Kansas City, Missouri, 64114, United States
GSK Investigational Site
Springfield, Missouri, 65807, United States
GSK Investigational Site
St Louis, Missouri, 63110-2539, United States
GSK Investigational Site
St Louis, Missouri, 63136, United States
GSK Investigational Site
St Louis, Missouri, 63141, United States
GSK Investigational Site
Billings, Montana, 59102, United States
GSK Investigational Site
Omaha, Nebraska, 68114, United States
GSK Investigational Site
Omaha, Nebraska, 68131, United States
GSK Investigational Site
Henderson, Nevada, 89014, United States
GSK Investigational Site
Las Vegas, Nevada, 89106, United States
GSK Investigational Site
Las Vegas, Nevada, 89148, United States
GSK Investigational Site
Reno, Nevada, 89502, United States
GSK Investigational Site
Reno, Nevada, 89511, United States
GSK Investigational Site
Lebanon, New Hampshire, 03756, United States
GSK Investigational Site
Edison, New Jersey, 08837, United States
GSK Investigational Site
Hackensack, New Jersey, 07601, United States
GSK Investigational Site
Lawrencevill, New Jersey, 08648, United States
GSK Investigational Site
Marlton, New Jersey, 08053, United States
GSK Investigational Site
Perth Amboy, New Jersey, 08861, United States
GSK Investigational Site
Voorhees Township, New Jersey, 08043, United States
GSK Investigational Site
West Orange, New Jersey, 07052, United States
GSK Investigational Site
Albany, New York, 12208, United States
GSK Investigational Site
Binghamton, New York, 13901, United States
GSK Investigational Site
Brooklyn, New York, 11234, United States
GSK Investigational Site
East Syracuse, New York, 13057, United States
GSK Investigational Site
Elmont, New York, 11003, United States
GSK Investigational Site
Endwell, New York, 13760, United States
GSK Investigational Site
Garden City, New York, 11530, United States
GSK Investigational Site
Great Neck, New York, 11021, United States
GSK Investigational Site
Mineola, New York, 11501, United States
GSK Investigational Site
New York, New York, 10016, United States
GSK Investigational Site
New York, New York, 10021, United States
GSK Investigational Site
Orchard Park, New York, 14127, United States
GSK Investigational Site
Poughkeepsie, New York, 12601, United States
GSK Investigational Site
Rochester, New York, 14642, United States
GSK Investigational Site
Staten Island, New York, 10304, United States
GSK Investigational Site
Syracuse, New York, 13210, United States
GSK Investigational Site
The Bronx, New York, 10467, United States
GSK Investigational Site
Cary, North Carolina, 27511, United States
GSK Investigational Site
Cary, North Carolina, 27518, United States
GSK Investigational Site
Chapel Hill, North Carolina, 27599-7600, United States
GSK Investigational Site
Charlotte, North Carolina, 28211, United States
GSK Investigational Site
Charlotte, North Carolina, 28262, United States
GSK Investigational Site
Charlotte, NC 28207, North Carolina, 28207, United States
GSK Investigational Site
Concord, North Carolina, 28025, United States
GSK Investigational Site
Durham, North Carolina, 27710, United States
GSK Investigational Site
Greensboro, North Carolina, 27403, United States
GSK Investigational Site
Greenville, North Carolina, 27834, United States
GSK Investigational Site
Raleigh, North Carolina, 27607, United States
GSK Investigational Site
Raleigh, North Carolina, 27612, United States
GSK Investigational Site
Winston-Salem, North Carolina, 27103, United States
GSK Investigational Site
Bismarck, North Dakota, 58501, United States
GSK Investigational Site
Cincinnati, Ohio, 45212, United States
GSK Investigational Site
Cincinnati, Ohio, 45219, United States
GSK Investigational Site
Columbus, Ohio, 43214, United States
GSK Investigational Site
Columbus, Ohio, 43220, United States
GSK Investigational Site
Columbus, Ohio, 43235, United States
GSK Investigational Site
Elyria, Ohio, 44035, United States
GSK Investigational Site
Kettering, Ohio, 45429, United States
GSK Investigational Site
Marion, Ohio, 43302, United States
GSK Investigational Site
Zanesville, Ohio, 43701, United States
GSK Investigational Site
Oklahoma City, Oklahoma, 73112, United States
GSK Investigational Site
Poca City, Oklahoma, 74601, United States
GSK Investigational Site
Tulsa, Oklahoma, 74146, United States
GSK Investigational Site
Oregon City, Oregon, 97045, United States
GSK Investigational Site
Portland, Oregon, 97205, United States
GSK Investigational Site
Portland, Oregon, 97210, United States
GSK Investigational Site
Portland, Oregon, 97213, United States
GSK Investigational Site
Springfield, Oregon, 97477, United States
GSK Investigational Site
Bala-Cynwyd, Pennsylvania, 19004, United States
GSK Investigational Site
Bryn Mawr, Pennsylvania, 19010, United States
GSK Investigational Site
Camp Hill, Pennsylvania, 17011, United States
GSK Investigational Site
Harrisburg, Pennsylvania, 17110, United States
GSK Investigational Site
Hershey, Pennsylvania, 17033-0850, United States
GSK Investigational Site
Lancaster, Pennsylvania, 17601, United States
GSK Investigational Site
Lancaster, Pennsylvania, 17604, United States
GSK Investigational Site
Monroeville, Pennsylvania, 15146, United States
GSK Investigational Site
Newton, Pennsylvania, 18940, United States
GSK Investigational Site
Philadelphia, Pennsylvania, 19107, United States
GSK Investigational Site
Philadelphia, Pennsylvania, 19141, United States
GSK Investigational Site
Philadelphia, Pennsylvania, 19144, United States
GSK Investigational Site
Philadelphia, Pennsylvania, 19152, United States
GSK Investigational Site
Pittsburgh, Pennsylvania, 15215, United States
GSK Investigational Site
Pittsburgh, Pennsylvania, 15232, United States
GSK Investigational Site
Rosemont, Pennsylvania, 19010, United States
GSK Investigational Site
Sellersville, Pennsylvania, 18960, United States
GSK Investigational Site
State College, Pennsylvania, 16801, United States
GSK Investigational Site
Cranston, Rhode Island, 02920, United States
GSK Investigational Site
Providence, Rhode Island, 02904, United States
GSK Investigational Site
West Warwick, Rhode Island, 02893, United States
GSK Investigational Site
Charleston, South Carolina, 29425, United States
GSK Investigational Site
Greenville, South Carolina, 29650, United States
GSK Investigational Site
Greer, South Carolina, 29651, United States
GSK Investigational Site
Myrtle Beach, South Carolina, 29572, United States
GSK Investigational Site
Simpsonville, South Carolina, 29681, United States
GSK Investigational Site
Fort Pierre, South Dakota, 57501, United States
GSK Investigational Site
Germantown, Tennessee, 38138, United States
GSK Investigational Site
Knoxville, Tennessee, 37920, United States
GSK Investigational Site
Memphis, Tennessee, 38119, United States
GSK Investigational Site
Nashville, Tennessee, 37209, United States
GSK Investigational Site
Nashville, Tennessee, 37232-2765, United States
GSK Investigational Site
Amarillo, Texas, 79106, United States
GSK Investigational Site
Arlington, Texas, 76017, United States
GSK Investigational Site
Austin, Texas, 78757, United States
GSK Investigational Site
Dallas, Texas, 75216, United States
GSK Investigational Site
Dallas, Texas, 75230, United States
GSK Investigational Site
Dallas, Texas, 75231, United States
GSK Investigational Site
Dallas, Texas, 75234, United States
GSK Investigational Site
Dallas, Texas, 75235, United States
GSK Investigational Site
Fort Worth, Texas, 76104, United States
GSK Investigational Site
Fort Worth, Texas, 76107, United States
GSK Investigational Site
Houston, Texas, 77024, United States
GSK Investigational Site
Houston, Texas, 77030, United States
GSK Investigational Site
San Antonio, Texas, 78229, United States
GSK Investigational Site
Texarkana, Texas, 75503, United States
GSK Investigational Site
Salt Lake City, Utah, 84107, United States
GSK Investigational Site
South Burlington, Vermont, 05403, United States
GSK Investigational Site
Alexandria, Virginia, 22302, United States
GSK Investigational Site
Charlottesville, Virginia, 22911, United States
GSK Investigational Site
Fairfax, Virginia, 22031, United States
GSK Investigational Site
Harrisonburg, Virginia, 22801, United States
GSK Investigational Site
Mechanicsville, Virginia, 23116, United States
GSK Investigational Site
Norfolk, Virginia, 23502, United States
GSK Investigational Site
Richmond, Virginia, 23249, United States
GSK Investigational Site
Salem, Virginia, 24153, United States
GSK Investigational Site
Virginia Beach, Virginia, 23454, United States
GSK Investigational Site
Graham, Washington, 98338, United States
GSK Investigational Site
Seattle, Washington, 98101, United States
GSK Investigational Site
Seattle, Washington, 98122, United States
GSK Investigational Site
Seattle, Washington, 98133, United States
GSK Investigational Site
Seattle, Washington, 98166, United States
GSK Investigational Site
Seattle, Washington, 98195, United States
GSK Investigational Site
Spokane, Washington, 99202, United States
GSK Investigational Site
Tacoma, Washington, 98405, United States
GSK Investigational Site
Tacoma, Washington, 98431, United States
GSK Investigational Site
Tacoma, Washington, 98499, United States
GSK Investigational Site
Madison, Wisconsin, 53715, United States
GSK Investigational Site
Milwaukee, Wisconsin, 53209, United States
GSK Investigational Site
Milwaukee, Wisconsin, 53215, United States
GSK Investigational Site
Cheyenne, Wyoming, 82001, United States
GSK Investigational Site
Av Córdoba 2424, Buenos Aires, 1120, Argentina
GSK Investigational Site
Bahía Blanca, Buenos Aires, 8001, Argentina
GSK Investigational Site
Capital Federal, Buenos Aires, 1425, Argentina
GSK Investigational Site
Capital Federal, Buenos Aires, 1437, Argentina
GSK Investigational Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1405BCH, Argentina
GSK Investigational Site
Córdoba, Córdoba Province, 5000, Argentina
GSK Investigational Site
Córdoba, Córdoba Province, 5016, Argentina
GSK Investigational Site
Rosario, Santa Fe Province, 2000, Argentina
GSK Investigational Site
Buenos Aires, C1416DRW, Argentina
GSK Investigational Site
Darlinghurst, New South Wales, 2010, Australia
GSK Investigational Site
Kogarah, New South Wales, 2217, Australia
GSK Investigational Site
Randwick, New South Wales, 2031, Australia
GSK Investigational Site
Westmead, New South Wales, 2145, Australia
GSK Investigational Site
Herston, Queensland, 4029, Australia
GSK Investigational Site
Kippa-Ring, Queensland, 4021, Australia
GSK Investigational Site
Woolloongabba, Queensland, 4102, Australia
GSK Investigational Site
Adelaide, South Australia, 5000, Australia
GSK Investigational Site
Mentone, Victoria, 3194, Australia
GSK Investigational Site
Parkville, Victoria, 3050, Australia
GSK Investigational Site
Innsbruck, A-6020, Austria
GSK Investigational Site
Vienna, A-1090, Austria
GSK Investigational Site
Vienna, A-1180, Austria
GSK Investigational Site
Minsk, 220036, Belarus
GSK Investigational Site
Minsk, 223052, Belarus
GSK Investigational Site
Aalst, 9300, Belgium
GSK Investigational Site
Antwerp, 2020, Belgium
GSK Investigational Site
Brussels, 1000, Belgium
GSK Investigational Site
Brussels, 1070, Belgium
GSK Investigational Site
Brussels, 1200, Belgium
GSK Investigational Site
Ghent, 9000, Belgium
GSK Investigational Site
Hasselt, 3500, Belgium
GSK Investigational Site
Kortrijk, 8500, Belgium
GSK Investigational Site
Leuven, 3000, Belgium
GSK Investigational Site
Mons, 7000, Belgium
GSK Investigational Site
Turnhout, 2300, Belgium
GSK Investigational Site
Wilrijk, 2610, Belgium
GSK Investigational Site
Yvoir, 5530, Belgium
GSK Investigational Site
Salvador, Estado de Bahia, 40210-341, Brazil
GSK Investigational Site
Belo Horizonte, Minas Gerais, 30140-073, Brazil
GSK Investigational Site
Rio de Janeiro, Rio de Janeiro, 20 551-030, Brazil
GSK Investigational Site
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
GSK Investigational Site
Porto Alegre, Rio Grande do Sul, 90470-340, Brazil
GSK Investigational Site
Ribeirão Preto, São Paulo, 14085-000, Brazil
GSK Investigational Site
São Paulo, São Paulo, 04122-000, Brazil
GSK Investigational Site
Sofia, 1000, Bulgaria
GSK Investigational Site
Sofia, 1431, Bulgaria
GSK Investigational Site
Sofia, 1606, Bulgaria
GSK Investigational Site
Sofia, 1756, Bulgaria
GSK Investigational Site
Varna, 9000, Bulgaria
GSK Investigational Site
Calgary, Alberta, T2V 4R6, Canada
GSK Investigational Site
Edmonton, Alberta, T5H 4B9, Canada
GSK Investigational Site
Kelowna, British Columbia, V1Y 2H4, Canada
GSK Investigational Site
Surrey, British Columbia, V3V 1N1, Canada
GSK Investigational Site
Vancouver, British Columbia, V5Z 1M9, Canada
GSK Investigational Site
Victoria, British Columbia, V8T 5G1, Canada
GSK Investigational Site
Victoria, British Columbia, V8V 3N1, Canada
GSK Investigational Site
Fredericton, New Brunswick, E3B 5B8, Canada
GSK Investigational Site
Miramichi, New Brunswick, E1V 1N9, Canada
GSK Investigational Site
Saint John, New Brunswick, E2L 3J8, Canada
GSK Investigational Site
Halifax, Nova Scotia, B3H 1Y6, Canada
GSK Investigational Site
Barrie, Ontario, L4M 7G1, Canada
GSK Investigational Site
Burlington, Ontario, L7N 3V2, Canada
GSK Investigational Site
Burlington, Ontario, L7S 1V2, Canada
GSK Investigational Site
Kingston, Ontario, K7L 2V7, Canada
GSK Investigational Site
Kitchener, Ontario, N2N 2B9, Canada
GSK Investigational Site
Markham, Ontario, L6B 1A1, Canada
GSK Investigational Site
Newmarket, Ontario, L3X 1W1, Canada
GSK Investigational Site
Niagara Falls, Ontario, L2E 6A6, Canada
GSK Investigational Site
North Bay, Ontario, P1B 7K8, Canada
GSK Investigational Site
North York, Ontario, M3B 3P1, Canada
GSK Investigational Site
Oakville, Ontario, L6H 3P1, Canada
GSK Investigational Site
Orillia, Ontario, L3V 7V1, Canada
GSK Investigational Site
Richmond Hill, Ontario, L4C 1T6, Canada
GSK Investigational Site
Toronto, Ontario, M1S 4V5, Canada
GSK Investigational Site
Toronto, Ontario, M3H 5S4, Canada
GSK Investigational Site
Toronto, Ontario, M4N 3M5, Canada
GSK Investigational Site
Toronto, Ontario, M5G 2M9, Canada
GSK Investigational Site
Toronto, Ontario, M6A 3B5, Canada
GSK Investigational Site
Chicoutimi, Quebec, G7H 4A3, Canada
GSK Investigational Site
Granby, Quebec, J2G 8Z9, Canada
GSK Investigational Site
Greenfield Park, Quebec, J4V 2H3, Canada
GSK Investigational Site
Laval, Quebec, H7G 2E6, Canada
GSK Investigational Site
Montreal, Quebec, H1T 2M4, Canada
GSK Investigational Site
Montreal, Quebec, H2L 4M1, Canada
GSK Investigational Site
Montreal, Quebec, H2X 3J4, Canada
GSK Investigational Site
Montreal, Quebec, H3A 1A1, Canada
GSK Investigational Site
Montreal, Quebec, H3S 1Z1, Canada
GSK Investigational Site
Montreal, Quebec, H4A 1S9, Canada
GSK Investigational Site
Pointe-Claire, Quebec, H9R 4S3, Canada
GSK Investigational Site
Québec, Quebec, G1R 2J6, Canada
GSK Investigational Site
Trois-Rivières, Quebec, G9A 3V7, Canada
GSK Investigational Site
Viña del Mar, Región de Valparaíso, Chile
GSK Investigational Site
Santiago, Región Metro de Santiago, Chile
GSK Investigational Site
Zagreb, 10000, Croatia
GSK Investigational Site
Herlev, 2730, Denmark
GSK Investigational Site
Middelfart, 5500, Denmark
GSK Investigational Site
Nakskov, 4900, Denmark
GSK Investigational Site
Tallinn, 13419, Estonia
GSK Investigational Site
Tallinn, Estonia
GSK Investigational Site
Helsinki, 00029, Finland
GSK Investigational Site
Helsinki, 00180, Finland
GSK Investigational Site
Kuopio, 70100, Finland
GSK Investigational Site
Lahti, 15850, Finland
GSK Investigational Site
Lappeenranta, 53100, Finland
GSK Investigational Site
Oulu, 90029, Finland
GSK Investigational Site
Oulu, 90100, Finland
GSK Investigational Site
Rovaniemi, 96400, Finland
GSK Investigational Site
Seinäjoki, 60220, Finland
GSK Investigational Site
Tampere, 33521, Finland
GSK Investigational Site
Turku, 20100, Finland
GSK Investigational Site
Amiens, 80094, France
GSK Investigational Site
Arcachon, 33120, France
GSK Investigational Site
Auch, 32000, France
GSK Investigational Site
Besançon, 25030, France
GSK Investigational Site
Bois-Bernard, 62320, France
GSK Investigational Site
Bordeaux, 33073, France
GSK Investigational Site
Boujan-sur-Libron, 34760, France
GSK Investigational Site
Cabestany, 66330, France
GSK Investigational Site
Caen, 14050, France
GSK Investigational Site
Cannes, 06400, France
GSK Investigational Site
Carpentras, 84200, France
GSK Investigational Site
Chalon-sur-Saône, 71100, France
GSK Investigational Site
Châlons-en-Champagne, 51000, France
GSK Investigational Site
Cholet, 49300, France
GSK Investigational Site
Créteil, 94010, France
GSK Investigational Site
Dijon, 21000, France
GSK Investigational Site
Domarin, 38300, France
GSK Investigational Site
Dunkirk, 59240, France
GSK Investigational Site
Fourmies, 59611, France
GSK Investigational Site
Grande-Synthe, 59760, France
GSK Investigational Site
Guilherand-Granges, 07500, France
GSK Investigational Site
Le Havre, 76600, France
GSK Investigational Site
Le Raincy, 93340, France
GSK Investigational Site
Lille, 59037, France
GSK Investigational Site
Longjumeau, 91161, France
GSK Investigational Site
Lyon, 69437, France
GSK Investigational Site
Marseille, 13008, France
GSK Investigational Site
Marseille, 13274, France
GSK Investigational Site
Montauban, 82000, France
GSK Investigational Site
Montpellier, 34000, France
GSK Investigational Site
Nîmes, 30900, France
GSK Investigational Site
Orléans, 45100, France
GSK Investigational Site
Orsay, 91401, France
GSK Investigational Site
Paris, 75475, France
GSK Investigational Site
Paris, 75877, France
GSK Investigational Site
Pau, 64000, France
GSK Investigational Site
Pierre-Bénite, 69495, France
GSK Investigational Site
Ploemeur, 56270, France
GSK Investigational Site
Poitiers, 86021, France
GSK Investigational Site
Reims, 51100, France
GSK Investigational Site
Rouen, 76000, France
GSK Investigational Site
Saint-Cyr-sur-Loire, 37540, France
GSK Investigational Site
Saint-Etienne, 42000, France
GSK Investigational Site
Saint-Etienne, 42013, France
GSK Investigational Site
Saint-Grégoire, 35760, France
GSK Investigational Site
Saint-Martin-d'Hères, 38400, France
GSK Investigational Site
Saint-Nazaire, 44600, France
GSK Investigational Site
Saint-Quentin, 02321, France
GSK Investigational Site
Suresnes, 92151, France
GSK Investigational Site
Toulouse, 31403, France
GSK Investigational Site
Tours, 37000, France
GSK Investigational Site
Tours, 37044, France
GSK Investigational Site
Troyes, 10000, France
GSK Investigational Site
Vannes, 56000, France
GSK Investigational Site
Backnang, Baden-Wurttemberg, 71522, Germany
GSK Investigational Site
Bad Schönborn, Baden-Wurttemberg, 76669, Germany
GSK Investigational Site
Bruchsal, Baden-Wurttemberg, 76646, Germany
GSK Investigational Site
Esslingen am Neckar, Baden-Wurttemberg, 73728, Germany
GSK Investigational Site
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
GSK Investigational Site
Kleinblittersdorf, Baden-Wurttemberg, 66271, Germany
GSK Investigational Site
Mannheim, Baden-Wurttemberg, 68307, Germany
GSK Investigational Site
Neckargemünd, Baden-Wurttemberg, 69151, Germany
GSK Investigational Site
Ostfildern, Baden-Wurttemberg, 73760, Germany
GSK Investigational Site
Rheinfelden, Baden-Wurttemberg, 79618, Germany
GSK Investigational Site
Waldkirch, Baden-Wurttemberg, 79183, Germany
GSK Investigational Site
Aichach, Bavaria, 86551, Germany
GSK Investigational Site
Augsburg, Bavaria, 86156, Germany
GSK Investigational Site
Bad Griesbach, Bavaria, 94086, Germany
GSK Investigational Site
Bamberg, Bavaria, 96047, Germany
GSK Investigational Site
Dachau, Bavaria, 85221, Germany
GSK Investigational Site
Ebersberg, Bavaria, 85560, Germany
GSK Investigational Site
Forchheim, Bavaria, 91301, Germany
GSK Investigational Site
Fürth, Bavaria, 90762, Germany
GSK Investigational Site
Garmisch-Partenkirchen, Bavaria, 82467, Germany
GSK Investigational Site
Günzburg, Bavaria, 89312, Germany
GSK Investigational Site
Herzogenaurach, Bavaria, 91074, Germany
GSK Investigational Site
Höchberg, Bavaria, 97204, Germany
GSK Investigational Site
Kelheim, Bavaria, 93309, Germany
GSK Investigational Site
Koenigsbrunn, Bavaria, 86343, Germany
GSK Investigational Site
Munich, Bavaria, 80336, Germany
GSK Investigational Site
Munich, Bavaria, 80539, Germany
GSK Investigational Site
Munich, Bavaria, 81927, Germany
GSK Investigational Site
Neumarkt in der Oberpfalz, Bavaria, 92318, Germany
GSK Investigational Site
Nuremberg, Bavaria, 90402, Germany
GSK Investigational Site
Nuremberg, Bavaria, 90441, Germany
GSK Investigational Site
Nuremberg, Bavaria, 90482, Germany
GSK Investigational Site
Nuremberg, Bavaria, 90489, Germany
GSK Investigational Site
Planegg, Bavaria, 82152, Germany
GSK Investigational Site
Rosenheim, Bavaria, 83022, Germany
GSK Investigational Site
Roth, Bavaria, 91154, Germany
GSK Investigational Site
Starnberg, Bavaria, 82310, Germany
GSK Investigational Site
Starnberg, Bavaria, 82319, Germany
GSK Investigational Site
Weiden, Bavaria, 92637, Germany
GSK Investigational Site
Weißenburg in Bayern, Bavaria, 91781, Germany
GSK Investigational Site
Wertheim, Bavaria, 97877, Germany
GSK Investigational Site
Hagenow, Brandenburg, 19230, Germany
GSK Investigational Site
Hennigsdorf, Brandenburg, 16761, Germany
GSK Investigational Site
Oranienburg, Brandenburg, 16515, Germany
GSK Investigational Site
Schwedt, Brandenburg, 16303, Germany
GSK Investigational Site
Senftenberg, Brandenburg, 01968, Germany
GSK Investigational Site
Strausberg, Brandenburg, 15344, Germany
GSK Investigational Site
Hamburg, Hamburg, 21029, Germany
GSK Investigational Site
Hamburg, Hamburg, 22299, Germany
GSK Investigational Site
Hamburg, Hamburg, 22303, Germany
GSK Investigational Site
Hamburg, Hamburg, 22459, Germany
GSK Investigational Site
Hamburg, Hamburg, 22587, Germany
GSK Investigational Site
Hamburg, Hamburg, 22767, Germany
GSK Investigational Site
Wedel, Hamburg, 22880, Germany
GSK Investigational Site
Bad Homburg, Hesse, 61348, Germany
GSK Investigational Site
Frankfurt am Main, Hesse, 60326, Germany
GSK Investigational Site
Frankfurt am Main, Hesse, 60594, Germany
GSK Investigational Site
Frankfurt am Main, Hesse, 65929, Germany
GSK Investigational Site
Frankfurt am Main, Hesse, 65933, Germany
GSK Investigational Site
Hochheim am Main, Hesse, 65239, Germany
GSK Investigational Site
Kelkheim, Hesse, 65779, Germany
GSK Investigational Site
Marburg, Hesse, 35039, Germany
GSK Investigational Site
Neustadt, Hesse, 67434, Germany
GSK Investigational Site
Offenbach, Hesse, 63067, Germany
GSK Investigational Site
Seligenstadt, Hesse, 63500, Germany
GSK Investigational Site
Vellmar, Hesse, 34246, Germany
GSK Investigational Site
Wiesbaden, Hesse, 65185, Germany
GSK Investigational Site
Braunschweig, Lower Saxony, 38100, Germany
GSK Investigational Site
Braunschweig, Lower Saxony, 38120, Germany
GSK Investigational Site
Bremervörde, Lower Saxony, 27432, Germany
GSK Investigational Site
Buchholz, Lower Saxony, 21244, Germany
GSK Investigational Site
Buxtehude, Lower Saxony, 21614, Germany
GSK Investigational Site
Ganderkesee, Lower Saxony, 27777, Germany
GSK Investigational Site
Göttingen, Lower Saxony, 37073, Germany
GSK Investigational Site
Hildesheim, Lower Saxony, 31134, Germany
GSK Investigational Site
Holzminden, Lower Saxony, 37603, Germany
GSK Investigational Site
Leer, Lower Saxony, 26789, Germany
GSK Investigational Site
Salzgitter, Lower Saxony, 38226, Germany
GSK Investigational Site
Wolfsburg, Lower Saxony, 38440, Germany
GSK Investigational Site
Bad Doberan, Mecklenburg-Vorpommern, 18209, Germany
GSK Investigational Site
Ludwigslust, Mecklenburg-Vorpommern, 19288, Germany
GSK Investigational Site
Ribnitz-Damgarten, Mecklenburg-Vorpommern, 18311, Germany
GSK Investigational Site
Rostock, Mecklenburg-Vorpommern, 18069, Germany
GSK Investigational Site
Rostock, Mecklenburg-Vorpommern, 18109, Germany
GSK Investigational Site
Schwerin, Mecklenburg-Vorpommern, 19053, Germany
GSK Investigational Site
Schwerin, Mecklenburg-Vorpommern, 19057, Germany
GSK Investigational Site
Wismar, Mecklenburg-Vorpommern, 23970, Germany
GSK Investigational Site
Aachen, North Rhine-Westphalia, 52078, Germany
GSK Investigational Site
Arnsberg, North Rhine-Westphalia, 59821, Germany
GSK Investigational Site
Bocholt, North Rhine-Westphalia, 46399, Germany
GSK Investigational Site
Bonn, North Rhine-Westphalia, 53177, Germany
GSK Investigational Site
Borken, North Rhine-Westphalia, 46325, Germany
GSK Investigational Site
Cologne, North Rhine-Westphalia, 50969, Germany
GSK Investigational Site
Dortmund, North Rhine-Westphalia, 44137, Germany
GSK Investigational Site
Duisburg, North Rhine-Westphalia, 47051, Germany
GSK Investigational Site
Duisburg, North Rhine-Westphalia, 47179, Germany
GSK Investigational Site
Duisburg, North Rhine-Westphalia, 47198, Germany
GSK Investigational Site
Dülmen, North Rhine-Westphalia, 48249, Germany
GSK Investigational Site
Düsseldorf, North Rhine-Westphalia, 40211, Germany
GSK Investigational Site
Düsseldorf, North Rhine-Westphalia, 40229, Germany
GSK Investigational Site
Düsseldorf, North Rhine-Westphalia, 40470, Germany
GSK Investigational Site
Erkrath, North Rhine-Westphalia, 40699, Germany
GSK Investigational Site
Essen, North Rhine-Westphalia, 45127, Germany
GSK Investigational Site
Essen, North Rhine-Westphalia, 45130, Germany
GSK Investigational Site
Gelsenkirchen, North Rhine-Westphalia, 45883, Germany
GSK Investigational Site
Gelsenkirchen, North Rhine-Westphalia, 45894, Germany
GSK Investigational Site
Kamp-Lintfort, North Rhine-Westphalia, 47475, Germany
GSK Investigational Site
Kempen, North Rhine-Westphalia, 47906, Germany
GSK Investigational Site
Königswinter, North Rhine-Westphalia, 53639, Germany
GSK Investigational Site
Krefeld, North Rhine-Westphalia, 47799, Germany
GSK Investigational Site
Krefeld, North Rhine-Westphalia, 47805, Germany
GSK Investigational Site
Langenfeld, North Rhine-Westphalia, 40764, Germany
GSK Investigational Site
Marl, North Rhine-Westphalia, 45770, Germany
GSK Investigational Site
Moers, North Rhine-Westphalia, 47445, Germany
GSK Investigational Site
Mülheim, North Rhine-Westphalia, 45475, Germany
GSK Investigational Site
Oberhausen, North Rhine-Westphalia, 46045, Germany
GSK Investigational Site
Paderborn, North Rhine-Westphalia, 33098, Germany
GSK Investigational Site
Pulheim, North Rhine-Westphalia, 50259, Germany
GSK Investigational Site
Wesseling, North Rhine-Westphalia, 50389, Germany
GSK Investigational Site
Wuppertal, North Rhine-Westphalia, 42103, Germany
GSK Investigational Site
Bad Bergzaben, Rhineland-Palatinate, 76887, Germany
GSK Investigational Site
Bad Ems, Rhineland-Palatinate, 56130, Germany
GSK Investigational Site
Dierdorf, Rhineland-Palatinate, 56269, Germany
GSK Investigational Site
Koblenz, Rhineland-Palatinate, 56068, Germany
GSK Investigational Site
Nieder-Olm, Rhineland-Palatinate, 55268, Germany
GSK Investigational Site
Homburg, Saarland, 66424, Germany
GSK Investigational Site
Bad Schlema, Saxony, 08301, Germany
GSK Investigational Site
Bautzen, Saxony, 02625, Germany
GSK Investigational Site
Chemnitz, Saxony, 09119, Germany
GSK Investigational Site
Chemnitz, Saxony, 09126, Germany
GSK Investigational Site
Döbeln, Saxony, 04720, Germany
GSK Investigational Site
Dresden, Saxony, 01307, Germany
GSK Investigational Site
Dresden, Saxony, 01324, Germany
GSK Investigational Site
Grimma, Saxony, 04668, Germany
GSK Investigational Site
Leipzig, Saxony, 04103, Germany
GSK Investigational Site
Leipzig, Saxony, 04105, Germany
GSK Investigational Site
Leipzig, Saxony, 04109, Germany
GSK Investigational Site
Leipzig, Saxony, 04179, Germany
GSK Investigational Site
Leipzig, Saxony, 04229, Germany
GSK Investigational Site
Markkleeberg, Saxony, 04416, Germany
GSK Investigational Site
Neustadt, Saxony, 01844, Germany
GSK Investigational Site
Oelsnitz, Saxony, 08606, Germany
GSK Investigational Site
Pirna, Saxony, 01796, Germany
GSK Investigational Site
Plauen, Saxony, 08523, Germany
GSK Investigational Site
Radebeul, Saxony, 01445, Germany
GSK Investigational Site
Schwarzenberg, Saxony, 08340, Germany
GSK Investigational Site
Wilkau-Haßlau, Saxony, 08112, Germany
GSK Investigational Site
Zwickau, Saxony, 08060, Germany
GSK Investigational Site
Dessau, Saxony-Anhalt, 06842, Germany
GSK Investigational Site
Dessau, Saxony-Anhalt, 06844, Germany
GSK Investigational Site
Eisleben Lutherstadt, Saxony-Anhalt, 06295, Germany
GSK Investigational Site
Gardelegen, Saxony-Anhalt, 39638, Germany
GSK Investigational Site
Halle, Saxony-Anhalt, 06132, Germany
GSK Investigational Site
Hettstedt, Saxony-Anhalt, 06333, Germany
GSK Investigational Site
Leuna, Saxony-Anhalt, 06237, Germany
GSK Investigational Site
Magdeburg, Saxony-Anhalt, 39104, Germany
GSK Investigational Site
Naumburg, Saxony-Anhalt, 06618, Germany
GSK Investigational Site
Weißenfels, Saxony-Anhalt, 06667, Germany
GSK Investigational Site
Wolmirstedt, Saxony-Anhalt, 39326, Germany
GSK Investigational Site
Ahrensburg, Schleswig-Holstein, 22926, Germany
GSK Investigational Site
Bad Schwartau, Schleswig-Holstein, 23611, Germany
GSK Investigational Site
Flensburg, Schleswig-Holstein, 24944, Germany
GSK Investigational Site
Hemmoor, Schleswig-Holstein, 21745, Germany
GSK Investigational Site
Husum, Schleswig-Holstein, 25813, Germany
GSK Investigational Site
Itzehoe, Schleswig-Holstein, 25524, Germany
GSK Investigational Site
Kiel, Schleswig-Holstein, 24143, Germany
GSK Investigational Site
Lauenburg, Schleswig-Holstein, 21481, Germany
GSK Investigational Site
Lübeck, Schleswig-Holstein, 23552, Germany
GSK Investigational Site
Lübeck, Schleswig-Holstein, 23562, Germany
GSK Investigational Site
Neumünster, Schleswig-Holstein, 24534, Germany
GSK Investigational Site
Plön, Schleswig-Holstein, 24306, Germany
GSK Investigational Site
Schleswig, Schleswig-Holstein, 24837, Germany
GSK Investigational Site
Berlin, State of Berlin, 10117, Germany
GSK Investigational Site
Berlin, State of Berlin, 10249, Germany
GSK Investigational Site
Berlin, State of Berlin, 10365, Germany
GSK Investigational Site
Berlin, State of Berlin, 10369, Germany
GSK Investigational Site
Berlin, State of Berlin, 10713, Germany
GSK Investigational Site
Berlin, State of Berlin, 10719, Germany
GSK Investigational Site
Berlin, State of Berlin, 10787, Germany
GSK Investigational Site
Berlin, State of Berlin, 12099, Germany
GSK Investigational Site
Berlin, State of Berlin, 12107, Germany
GSK Investigational Site
Berlin, State of Berlin, 12627, Germany
GSK Investigational Site
Berlin, State of Berlin, 12687, Germany
GSK Investigational Site
Berlin, State of Berlin, 13187, Germany
GSK Investigational Site
Berlin, State of Berlin, 13507, Germany
GSK Investigational Site
Berlin, State of Berlin, 14057, Germany
GSK Investigational Site
Gera, Thuringia, 07546, Germany
GSK Investigational Site
Gotha, Thuringia, 99867, Germany
GSK Investigational Site
Ilmenau, Thuringia, 98693, Germany
GSK Investigational Site
Meiningen, Thuringia, 98617, Germany
GSK Investigational Site
Waltershausen, Thuringia, 99880, Germany
GSK Investigational Site
Athens, 10552, Greece
GSK Investigational Site
Athens, 106 82, Greece
GSK Investigational Site
Athens, 10676, Greece
GSK Investigational Site
Athens, 115 22, Greece
GSK Investigational Site
Athens, 11526, Greece
GSK Investigational Site
Athens, 18537, Greece
GSK Investigational Site
Heraklion, Crete, 71110, Greece
GSK Investigational Site
Ioannina, 45 500, Greece
GSK Investigational Site
Larissa, 41110, Greece
GSK Investigational Site
Periohi Dragana, Alexandroupolis, 68100, Greece
GSK Investigational Site
Rhodes, 85100, Greece
GSK Investigational Site
Rio, Patras, 265 00, Greece
GSK Investigational Site
Thessaloniki, 54642, Greece
GSK Investigational Site
Thessaloniki, 56429, Greece
GSK Investigational Site
Budapest, 1082, Hungary
GSK Investigational Site
Budapest, 1204, Hungary
GSK Investigational Site
Győr, 9002, Hungary
GSK Investigational Site
Kecskemét, 6000, Hungary
GSK Investigational Site
Miskolc, 3501, Hungary
GSK Investigational Site
Cork, Ireland
GSK Investigational Site
Dublin, 7, Ireland
GSK Investigational Site
Tallaght, Ireland
GSK Investigational Site
Lanciano (CH), Abruzzo, 66034, Italy
GSK Investigational Site
Bari, Apulia, 70124, Italy
GSK Investigational Site
Caserta, Campania, 81100, Italy
GSK Investigational Site
Napoli, Campania, 80131, Italy
GSK Investigational Site
Forlì, Emilia-Romagna, 47100, Italy
GSK Investigational Site
Rome, Lazio, 00161, Italy
GSK Investigational Site
Milan, Lombardy, 20122, Italy
GSK Investigational Site
Milan, Lombardy, 20132, Italy
GSK Investigational Site
Voghera (PV), Lombardy, 27058, Italy
GSK Investigational Site
Cagliari, Sardinia, 09100, Italy
GSK Investigational Site
Sassari, Sardinia, 07100, Italy
GSK Investigational Site
Catania, Sicily, 95124, Italy
GSK Investigational Site
Ragusa (CT), Sicily, 97100, Italy
GSK Investigational Site
Pisa, Tuscany, 56126, Italy
GSK Investigational Site
Isola Della Scala (VR), Veneto, 37063, Italy
GSK Investigational Site
Napoli, Veneto, 80131, Italy
GSK Investigational Site
Chiba, 289-2511, Japan
GSK Investigational Site
Fukuoka, 810-0001, Japan
GSK Investigational Site
Hokkaido, 060-8543, Japan
GSK Investigational Site
Ibaraki, 305-8576, Japan
GSK Investigational Site
Nagasaki, 852-8501, Japan
GSK Investigational Site
Ōita, 874-0937, Japan
GSK Investigational Site
Daugavpils, LV5403, Latvia
GSK Investigational Site
Riga, LV 1001, Latvia
GSK Investigational Site
Riga, LV 1002, Latvia
GSK Investigational Site
Riga, LV 1006, Latvia
GSK Investigational Site
Riga, LV1079, Latvia
GSK Investigational Site
Kaunas, LT-50009, Lithuania
GSK Investigational Site
Šiauliai, LT-76231, Lithuania
GSK Investigational Site
Vilnius, LT-05263, Lithuania
GSK Investigational Site
Vilnius, LT-08660, Lithuania
GSK Investigational Site
Vilnius, LT-08661, Lithuania
GSK Investigational Site
Durango, Durango, 34000, Mexico
GSK Investigational Site
Durango, Durango, 34027, Mexico
GSK Investigational Site
Zapopan, Jalisco, 45170, Mexico
GSK Investigational Site
Zapopan, Jalisco, 45200, Mexico
GSK Investigational Site
Zapopan, Jalisco, Jalisco, 45100, Mexico
GSK Investigational Site
Mexico City, 06720, Mexico
GSK Investigational Site
Mexico City, 14000, Mexico
GSK Investigational Site
México, 06700, Mexico
GSK Investigational Site
México, 14000, Mexico
GSK Investigational Site
Puebla City, 72500, Mexico
GSK Investigational Site
's-Hertogenbosch, 5232 JL, Netherlands
GSK Investigational Site
Amsterdam, 1061 AE, Netherlands
GSK Investigational Site
Amsterdam, 1091 AC, Netherlands
GSK Investigational Site
Arnhem, 6815 AD, Netherlands
GSK Investigational Site
Breda, 4819 EV, Netherlands
GSK Investigational Site
Capelle aan den IJssel, 2906 ZC, Netherlands
GSK Investigational Site
Ede, 6716 RP, Netherlands
GSK Investigational Site
Eindhoven, 5623 EJ, Netherlands
GSK Investigational Site
Harderwijk, 3844 DG, Netherlands
GSK Investigational Site
Hengelo, 7555 DL, Netherlands
GSK Investigational Site
Nieuwegein, 3435 CM, Netherlands
GSK Investigational Site
Nijmegen, 6525 GA, Netherlands
GSK Investigational Site
Nijmegen, 6532 SZ, Netherlands
GSK Investigational Site
Roermond, 6040 AX, Netherlands
GSK Investigational Site
Roosendaal, 4708 AE, Netherlands
GSK Investigational Site
Rotterdam, 3015 GD, Netherlands
GSK Investigational Site
Rotterdam, 3078 HT, Netherlands
GSK Investigational Site
Stadskanaal, 9501 HE, Netherlands
GSK Investigational Site
The Hague, 2512 VA, Netherlands
GSK Investigational Site
The Hague, 2545 CH, Netherlands
GSK Investigational Site
Tilburg, 5022 GC, Netherlands
GSK Investigational Site
Auckland, 1142, New Zealand
GSK Investigational Site
Christchurch, 8014, New Zealand
GSK Investigational Site
Hamilton, 3204, New Zealand
GSK Investigational Site
Nelson, 7010, New Zealand
GSK Investigational Site
Tauranga, 3140, New Zealand
GSK Investigational Site
Whangarei, 0112, New Zealand
GSK Investigational Site
Arendal, N-4838, Norway
GSK Investigational Site
Moelv, N-2390, Norway
GSK Investigational Site
Oslo, 0257 OSLO, Norway
GSK Investigational Site
Porsgrunn, N-3922, Norway
GSK Investigational Site
Stavanger, N-4068, Norway
GSK Investigational Site
Bydgoszcz, 85-094, Poland
GSK Investigational Site
Bydgoszcz, 85-168, Poland
GSK Investigational Site
Chęciny, 26-060, Poland
GSK Investigational Site
Elblag, 82-300, Poland
GSK Investigational Site
Gdansk, 80-462, Poland
GSK Investigational Site
Inowrocław, 88-100, Poland
GSK Investigational Site
Katowice, 40-954, Poland
GSK Investigational Site
Kościerzyna, 83-400, Poland
GSK Investigational Site
Krakow, 31-531, Poland
GSK Investigational Site
Lublin, 20-718, Poland
GSK Investigational Site
Rzeszów, 35-055, Poland
GSK Investigational Site
Szczecin, 70-111, Poland
GSK Investigational Site
Warsaw, 02-005, Poland
GSK Investigational Site
Warsaw, 02-781, Poland
GSK Investigational Site
Warsaw, 04-749, Poland
GSK Investigational Site
Wejherowo, 84-200, Poland
GSK Investigational Site
Wroclaw, 51-124, Poland
GSK Investigational Site
Almada, 2805-267, Portugal
GSK Investigational Site
Amadora, 2700, Portugal
GSK Investigational Site
Lisbon, Portugal
GSK Investigational Site
Porto, 4099-004, Portugal
GSK Investigational Site
Porto, Portugal
GSK Investigational Site
Ponce, Puerto Rico, 00716, Puerto Rico
GSK Investigational Site
San Juan, Puerto Rico, 00909-1711, Puerto Rico
GSK Investigational Site
San Juan, Puerto Rico, 00921-3201, Puerto Rico
GSK Investigational Site
Bucharest, Romania
GSK Investigational Site
Moscow, 105 229, Russia
GSK Investigational Site
Moscow, 111 123, Russia
GSK Investigational Site
Moscow, 117 049, Russia
GSK Investigational Site
Moscow, 119 881, Russia
GSK Investigational Site
Moscow, Russia
GSK Investigational Site
Nizhny Novgorod, 603005, Russia
GSK Investigational Site
Saint Petersburg, 197 089, Russia
GSK Investigational Site
Saint Petersburg, 198 013, Russia
GSK Investigational Site
Saratov, 410012, Russia
GSK Investigational Site
Bratislava, 833 05, Slovakia
GSK Investigational Site
Martin, 036 59, Slovakia
GSK Investigational Site
Celje, 3000, Slovenia
GSK Investigational Site
Ljubljana, 1000, Slovenia
GSK Investigational Site
Maribor, 2000, Slovenia
GSK Investigational Site
Slovenj Gradec, 2380, Slovenia
GSK Investigational Site
Rosebank, Gauteng, 2196, South Africa
GSK Investigational Site
Cape Town, 7505, South Africa
GSK Investigational Site
Cape Town, South Africa
GSK Investigational Site
Capital Park, 0002, South Africa
GSK Investigational Site
George, 6529, South Africa
GSK Investigational Site
Johannesburg, 2193, South Africa
GSK Investigational Site
Parktown, 2193, South Africa
GSK Investigational Site
Pretoria, 83, South Africa
GSK Investigational Site
Westville, Durban, 3630, South Africa
GSK Investigational Site
Alava, 01004, Spain
GSK Investigational Site
Alcala de Henares (Madrid), Spain
GSK Investigational Site
Alcorcón, 28922, Spain
GSK Investigational Site
Badalona, 08916, Spain
GSK Investigational Site
Barcelona, 08003, Spain
GSK Investigational Site
Barcelona, 08024, Spain
GSK Investigational Site
Barcelona, 08025, Spain
GSK Investigational Site
Barcelona, 08035, Spain
GSK Investigational Site
Barcelona, 08036, Spain
GSK Investigational Site
Barcelona, 8907, Spain
GSK Investigational Site
Bilbao, 48013, Spain
GSK Investigational Site
Castellon, 12004, Spain
GSK Investigational Site
Ciudad Real, 13600, Spain
GSK Investigational Site
Don Benito (Badajoz), 06400, Spain
GSK Investigational Site
Donostia / San Sebastian, 20014, Spain
GSK Investigational Site
Galdakano, 48960, Spain
GSK Investigational Site
Granada, 18012, Spain
GSK Investigational Site
Ibiza Town, 07800, Spain
GSK Investigational Site
Jaén, 27007, Spain
GSK Investigational Site
La Laguna (Santa Cruz de Tenerife), 38320, Spain
GSK Investigational Site
Leganés, Spain
GSK Investigational Site
Logroño, 26006, Spain
GSK Investigational Site
Madrid, 28003, Spain
GSK Investigational Site
Madrid, 28006, Spain
GSK Investigational Site
Madrid, 28007, Spain
GSK Investigational Site
Madrid, 28010, Spain
GSK Investigational Site
Madrid, 28034, Spain
GSK Investigational Site
Madrid, 28040, Spain
GSK Investigational Site
Madrid, 28047, Spain
GSK Investigational Site
Manacor, 07500, Spain
GSK Investigational Site
Málaga, 29010, Spain
GSK Investigational Site
Orihuela, Spain
GSK Investigational Site
Oviedo, 33006, Spain
GSK Investigational Site
Pamplona, 31008, Spain
GSK Investigational Site
Sagunto, 46520, Spain
GSK Investigational Site
Sant Joan d'Alacant, 3550, Spain
GSK Investigational Site
Santa Cruz de Tenerife, 38010, Spain
GSK Investigational Site
Seville, 41013, Spain
GSK Investigational Site
Seville, 41014, Spain
GSK Investigational Site
Seville, 41018, Spain
GSK Investigational Site
Seville, 41071, Spain
GSK Investigational Site
Soria, 42002, Spain
GSK Investigational Site
Valencia, 46009, Spain
GSK Investigational Site
Valencia, 46010, Spain
GSK Investigational Site
Valencia, 46014, Spain
GSK Investigational Site
Valladolid, 47012, Spain
GSK Investigational Site
Via-Real (Castellón), 12540, Spain
GSK Investigational Site
Borås, SE-503 32, Sweden
GSK Investigational Site
Eskilstuna, SE-633 40, Sweden
GSK Investigational Site
Gävle, SE-801 87, Sweden
GSK Investigational Site
Gothenburg, SE-412 55, Sweden
GSK Investigational Site
Gothenburg, SE-417 17, Sweden
GSK Investigational Site
Karlshamn, SE-374 35, Sweden
GSK Investigational Site
Kristianstad, SE-291 31, Sweden
GSK Investigational Site
Kristianstad, SE-291 85, Sweden
GSK Investigational Site
Malmo, SE-217 44, Sweden
GSK Investigational Site
Östersund, SE-831 31, Sweden
GSK Investigational Site
Skärholmen, SE-127 48, Sweden
GSK Investigational Site
Skövde, SE-541 30, Sweden
GSK Investigational Site
Stockholm, SE-118 83, Sweden
GSK Investigational Site
Umeå, SE-901 85, Sweden
GSK Investigational Site
Vålberg, SE-660 50, Sweden
GSK Investigational Site
Aarau, 5001, Switzerland
GSK Investigational Site
Bern, 3000, Switzerland
GSK Investigational Site
Biel, 2500, Switzerland
GSK Investigational Site
Fribourg, 1700, Switzerland
GSK Investigational Site
Geneva, 1206, Switzerland
GSK Investigational Site
Lausanne, 1003, Switzerland
GSK Investigational Site
Olten, 4600, Switzerland
GSK Investigational Site
Sarnen, 6060, Switzerland
GSK Investigational Site
Zollikon, 8702, Switzerland
GSK Investigational Site
Sfax, 3027, Tunisia
GSK Investigational Site
Sousse, 4054, Tunisia
GSK Investigational Site
Tunis, 1006, Tunisia
GSK Investigational Site
Tunis, 1007, Tunisia
GSK Investigational Site
Tunis, 1008, Tunisia
GSK Investigational Site
Ankara, Turkey (Türkiye)
GSK Investigational Site
Capa/Istanbul, Turkey (Türkiye)
GSK Investigational Site
Istanbul, Turkey (Türkiye)
GSK Investigational Site
Izmir, Turkey (Türkiye)
GSK Investigational Site
Dnipro, 49005, Ukraine
GSK Investigational Site
Kharkiv, 61037, Ukraine
GSK Investigational Site
Odesa, 65074, Ukraine
GSK Investigational Site
Zaporizhzhya, 69103, Ukraine
GSK Investigational Site
Aberdeen, Aberdeenshire, AB25 2ZD, United Kingdom
GSK Investigational Site
Ayr, Ayrshire, KA6 6DX, United Kingdom
GSK Investigational Site
Reading, Berkshire, RG2 0TG, United Kingdom
GSK Investigational Site
Stockport, Cheshire, SK2 7JE, United Kingdom
GSK Investigational Site
Exeter, Devon, EX2 5DW, United Kingdom
GSK Investigational Site
Plymouth, Devon, PL6 8DH, United Kingdom
GSK Investigational Site
Cardiff, Glamorgan, CF14 5GJ, United Kingdom
GSK Investigational Site
Bristol, Gloucestershire, BS10 5NB, United Kingdom
GSK Investigational Site
Portsmouth, Hampshire, PO3 6AD, United Kingdom
GSK Investigational Site
Southampton, Hampshire, SO16 6YD, United Kingdom
GSK Investigational Site
Stevenage, Hertfordshire, SG2 4AB, United Kingdom
GSK Investigational Site
Glasgow, Lanarkshire, G51 4TF, United Kingdom
GSK Investigational Site
Buckshaw Village, Chorley, Lancashire, PR7 7NA, United Kingdom
GSK Investigational Site
Lancs, Lancashire, PR7 1PP, United Kingdom
GSK Investigational Site
Manchester, Lancashire, M41 5SL, United Kingdom
GSK Investigational Site
Manchester, Lancashire, M8 5RB, United Kingdom
GSK Investigational Site
Oldham, Lancashire, OL1 2JH, United Kingdom
GSK Investigational Site
Leicester, Leicestershire, LE5 4PW, United Kingdom
GSK Investigational Site
Leytonstone, London, E11 1NR, United Kingdom
GSK Investigational Site
Liverpool, Merseyside, L1 9AD, United Kingdom
GSK Investigational Site
Liverpool, Merseyside, L7 8XP, United Kingdom
GSK Investigational Site
Edinburgh, Midlothian, EH4 2XU, United Kingdom
GSK Investigational Site
Norwich, Norfolk, NR4 7FP, United Kingdom
GSK Investigational Site
Newcastle upon Tyne, Northumberland, NE7 7DN, United Kingdom
GSK Investigational Site
Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
GSK Investigational Site
Bath, Somerset, BA1 1BX, United Kingdom
GSK Investigational Site
Tauton, Somerset, TA1 5DA, United Kingdom
GSK Investigational Site
Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
GSK Investigational Site
Redhill, Surrey, RH1 5RH, United Kingdom
GSK Investigational Site
Chichester, Sussex West, PO19 4SE, United Kingdom
GSK Investigational Site
Birmingham, Warwickshire, B9 5SS, United Kingdom
GSK Investigational Site
Coventry, Warwickshire, CV1 2TZ, United Kingdom
GSK Investigational Site
Bradford, BD5 0NA, United Kingdom
GSK Investigational Site
Bristol, BS2 8HW, United Kingdom
GSK Investigational Site
Clydebank, Glasgow, G81 2DR, United Kingdom
GSK Investigational Site
Crewe, CW1 4QJ, United Kingdom
GSK Investigational Site
Edgbaston, Birmingham, B15 2SQ, United Kingdom
GSK Investigational Site
Falkirk, FK1 5QE, United Kingdom
GSK Investigational Site
Leeds, LS9 7TF, United Kingdom
GSK Investigational Site
London, EC1 7BE, United Kingdom
GSK Investigational Site
London, NW3 2QG, United Kingdom
GSK Investigational Site
London, SW17 0QT, United Kingdom
GSK Investigational Site
London, W1P 7PN, United Kingdom
GSK Investigational Site
Manchester, M15 6SX, United Kingdom
GSK Investigational Site
Sheffield, S10 2JF, United Kingdom
GSK Investigational Site
Torquay, TQ2 7AA, United Kingdom
GSK Investigational Site
Wakefield, WF1 4DG, United Kingdom
GSK Investigational Site
Waterloo, Liverpool, L22 0LG, United Kingdom
GSK Investigational Site
Wolverhampton, WV10 9RU, United Kingdom
GSK Investigational Site
Related Publications (28)
Kader AK, Sun J, Reck BH, Newcombe PJ, Kim ST, Hsu FC, D'Agostino RB Jr, Tao S, Zhang Z, Turner AR, Platek GT, Spraggs CF, Whittaker JC, Lane BR, Isaacs WB, Meyers DA, Bleecker ER, Torti FM, Trent JM, McConnell JD, Zheng SL, Condreay LD, Rittmaster RS, Xu J. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. Eur Urol. 2012 Dec;62(6):953-61. doi: 10.1016/j.eururo.2012.05.006. Epub 2012 May 12.
PMID: 22652152BACKGROUNDAubin SM, Reid J, Sarno MJ, Blase A, Aussie J, Rittenhouse H, Rittmaster R, Andriole GL, Groskopf J. PCA3 molecular urine test for predicting repeat prostate biopsy outcome in populations at risk: validation in the placebo arm of the dutasteride REDUCE trial. J Urol. 2010 Nov;184(5):1947-52. doi: 10.1016/j.juro.2010.06.098. Epub 2010 Sep 17.
PMID: 20850153BACKGROUNDWu C, Moreira DM, Gerber L, Rittmaster RS, Andriole GL, Freedland SJ. Diabetes and prostate cancer risk in the REDUCE trial. Prostate Cancer Prostatic Dis. 2011 Dec;14(4):326-31. doi: 10.1038/pcan.2011.28. Epub 2011 Jun 28.
PMID: 21709690BACKGROUNDRoehrborn CG, Nickel JC, Andriole GL, Gagnier RP, Black L, Wilson TH, Rittmaster RS. Dutasteride improves outcomes of benign prostatic hyperplasia when evaluated for prostate cancer risk reduction: secondary analysis of the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial. Urology. 2011 Sep;78(3):641-6. doi: 10.1016/j.urology.2011.03.063. Epub 2011 Jul 20.
PMID: 21764428BACKGROUNDBostwick DG, Qian J, Drewnowska K, Varvel S, Bostwick KC, Marberger M, Rittmaster RS. Prostate needle biopsy quality in reduction by dutasteride of prostate cancer events study: worldwide comparison of improvement with investigator training and centralized laboratory processing. Urology. 2010 Jun;75(6):1406-10. doi: 10.1016/j.urology.2009.07.1348. Epub 2009 Nov 25.
PMID: 19942263BACKGROUNDCrawford ED, Andriole GL, Marberger M, Rittmaster RS. Reduction in the risk of prostate cancer: future directions after the Prostate Cancer Prevention Trial. Urology. 2010 Mar;75(3):502-9. doi: 10.1016/j.urology.2009.05.099. Epub 2009 Dec 29.
PMID: 20035983BACKGROUNDG Andriole, D Bostwick, O Brawley, L Gomella, M Marberger, F Montorsi, C Pettaway, T Tammela, C Teloken, D Tindall, M Somerville, I Fowler and R Rittmaster on behalf of the REDUCE Study Group. Risk reduction in men at increased risk: outcomes of the REduction by Dutasteride of prostate Cancer Events (REDUCE) trial. [N Engl J Med]. 2010;362(13):1192-202.
BACKGROUNDAndriole GL, Bostwick D, Brawley OW, Gomella L, Marberger M, Montorsi F, Pettaway C, Tammela TL, Teloken C, Tindall D, Freedland SJ, Somerville MC, Wilson TH, Fowler I, Castro R, Rittmaster RS; REDUCE Study Group. The effect of dutasteride on the usefulness of prostate specific antigen for the diagnosis of high grade and clinically relevant prostate cancer in men with a previous negative biopsy: results from the REDUCE study. J Urol. 2011 Jan;185(1):126-31. doi: 10.1016/j.juro.2010.09.011. Epub 2010 Nov 12.
PMID: 21074214BACKGROUNDAndriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS; REDUCE Study Group. Effect of dutasteride on the risk of prostate cancer. N Engl J Med. 2010 Apr 1;362(13):1192-202. doi: 10.1056/NEJMoa0908127.
PMID: 20357281BACKGROUNDNickel JC, Roehrborn C, Montorsi F, Wilson TH, Rittmaster RS. Dutasteride reduces prostatitis symptoms compared with placebo in men enrolled in the REDUCE study. J Urol. 2011 Oct;186(4):1313-8. doi: 10.1016/j.juro.2011.05.071. Epub 2011 Aug 17.
PMID: 21849186BACKGROUNDJean-Alfred Thomas, II, Leah Gerber, Lionel Banez, Daniel Moreira,Ramiro Castro, Gerald L. Andriole and Stephen J. Freedland. Prostate Cancer Risk in Men with Prostate and Breast Cancer Family History: Results from the REDUCE study. [J Intern Med [Epub Dec 28 2011]]. 2011;
BACKGROUNDMarberger M, McConnell JD, Fowler I, Andriole GL, Bostwick DG, Somerville MC, Rittmaster RS. Biopsy misidentification identified by DNA profiling in a large multicenter trial. J Clin Oncol. 2011 May 1;29(13):1744-9. doi: 10.1200/JCO.2010.32.1646. Epub 2011 Mar 28.
PMID: 21444877BACKGROUNDMarberger M, Freedland SJ, Andriole GL, Emberton M, Pettaway C, Montorsi F, Teloken C, Rittmaster RS, Somerville MC, Castro R. Usefulness of prostate-specific antigen (PSA) rise as a marker of prostate cancer in men treated with dutasteride: lessons from the REDUCE study. BJU Int. 2012 Apr;109(8):1162-9. doi: 10.1111/j.1464-410X.2011.10373.x. Epub 2011 Jun 23.
PMID: 21699645BACKGROUNDMarberger M, Wilson TH, Rittmaster RS. Low serum testosterone levels are poor predictors of sexual dysfunction. BJU Int. 2011 Jul;108(2):256-62. doi: 10.1111/j.1464-410X.2010.09766.x. Epub 2010 Oct 18.
PMID: 20955266BACKGROUNDKattan MW, Earnshaw SR, McDade CL, Black LK, Andriole GL. Cost effectiveness of chemoprevention for prostate cancer with dutasteride in a high-risk population based on results from the REDUCE clinical trial. Appl Health Econ Health Policy. 2011 Sep 1;9(5):305-15. doi: 10.2165/11592200-000000000-00000.
PMID: 21875161BACKGROUNDMuller RL, Gerber L, Moreira DM, Andriole G, Castro-Santamaria R, Freedland SJ. Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial. Eur Urol. 2012 Nov;62(5):757-64. doi: 10.1016/j.eururo.2012.05.025. Epub 2012 May 18.
PMID: 22658758BACKGROUNDNewcombe PJ, Reck BH, Sun J, Platek GT, Verzilli C, Kader AK, Kim ST, Hsu FC, Zhang Z, Zheng SL, Mooser VE, Condreay LD, Spraggs CF, Whittaker JC, Rittmaster RS, Xu J. A comparison of Bayesian and frequentist approaches to incorporating external information for the prediction of prostate cancer risk. Genet Epidemiol. 2012 Jan;36(1):71-83. doi: 10.1002/gepi.21600.
PMID: 22890972BACKGROUNDAubin SM, Reid J, Sarno MJ, Blase A, Aussie J, Rittenhouse H, Rittmaster RS, Andriole GL, Groskopf J. Prostate cancer gene 3 score predicts prostate biopsy outcome in men receiving dutasteride for prevention of prostate cancer: results from the REDUCE trial. Urology. 2011 Aug;78(2):380-5. doi: 10.1016/j.urology.2011.03.033.
PMID: 21820580BACKGROUNDStephen J. Freedland, Leah Gerber, Lionel Banez, Daniel Moreira, Gerald L. Andriole, and Roger S. Rittmaster on behalf of the REDUCE Study Group. Statin Use and the Risk of Prostate Cancer and High-grade Prostate Cancer: Results from the REDUCE study. [AUA 2011 Annual Meeting]. 2011;185(4 Suppl):e135.
BACKGROUNDThomas JA 2nd, Gerber L, Banez LL, Moreira DM, Rittmaster RS, Andriole GL, Freedland SJ. Prostate cancer risk in men with baseline history of coronary artery disease: results from the REDUCE Study. Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):576-81. doi: 10.1158/1055-9965.EPI-11-1017. Epub 2012 Feb 7.
PMID: 22315364BACKGROUNDVidal AC, Oyekunle T, Feng T, Freedland AR, Moreira D, Castro-Santamaria R, Andriole GL, Freedland SJ, Allott EH. Asian Race and Risk of Prostate Cancer: Results from the REDUCE Study. Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2165-2170. doi: 10.1158/1055-9965.EPI-20-0646. Epub 2020 Aug 20.
PMID: 32856605DERIVEDBliwise DL, Howard LE, Moreira DM, Andriole GL, Hopp ML, Freedland SJ. Nocturia and associated mortality: observational data from the REDUCE trial. Prostate Cancer Prostatic Dis. 2019 Mar;22(1):77-83. doi: 10.1038/s41391-018-0090-5. Epub 2018 Sep 13.
PMID: 30214036DERIVEDMoreira DM, Andriole GL, Nickel JC, Roehrborn CG, Castro-Santamaria R, Freedland SJ. Dutasteride is associated with reduced risk of transrectal prostate biopsy-associated urinary tract infection and related hospitalizations. World J Urol. 2017 Oct;35(10):1525-1530. doi: 10.1007/s00345-017-2036-2. Epub 2017 Apr 10.
PMID: 28396999DERIVEDNickel JC, Roehrborn CG, Castro-Santamaria R, Freedland SJ, Moreira DM. Chronic Prostate Inflammation is Associated with Severity and Progression of Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms and Risk of Acute Urinary Retention. J Urol. 2016 Nov;196(5):1493-1498. doi: 10.1016/j.juro.2016.06.090. Epub 2016 Jul 1.
PMID: 27378134DERIVEDMoreira DM, Nickel JC, Andriole GL, Castro-Santamaria R, Freedland SJ. Chronic baseline prostate inflammation is associated with lower tumor volume in men with prostate cancer on repeat biopsy: Results from the REDUCE study. Prostate. 2015 Sep;75(13):1492-8. doi: 10.1002/pros.23041. Epub 2015 Jul 17.
PMID: 26184556DERIVEDMoreira DM, Bostwick DG, Andriole GL, Peterson BL, Cohen HJ, Castro-Santamaria R, Freedland SJ. Baseline Prostate Atrophy is Associated with Reduced Risk of Prostate Cancer in Men Undergoing Repeat Prostate Biopsy. J Urol. 2015 Nov;194(5):1241-6. doi: 10.1016/j.juro.2015.05.103. Epub 2015 Jul 10.
PMID: 26165588DERIVEDToren P, Margel D, Kulkarni G, Finelli A, Zlotta A, Fleshner N. Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study. BMJ. 2013 Apr 15;346:f2109. doi: 10.1136/bmj.f2109.
PMID: 23587564DERIVEDMuller RL, Gerber L, Moreira DM, Andriole G Jr, Hamilton RJ, Fleshner N, Parsons JK, Freedland SJ. Obesity is associated with increased prostate growth and attenuated prostate volume reduction by dutasteride. Eur Urol. 2013 Jun;63(6):1115-21. doi: 10.1016/j.eururo.2013.02.038. Epub 2013 Mar 7.
PMID: 23541458DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- GSK Response Center
- Organization
- GlaxoSmithKline
Study Officials
- STUDY DIRECTOR
GSK Clinical Trials
GlaxoSmithKline
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 11, 2003
First Posted
March 13, 2003
Study Start
March 1, 2003
Primary Completion
January 1, 2009
Study Completion
April 1, 2009
Last Updated
September 23, 2016
Results First Posted
March 5, 2010
Record last verified: 2016-08
Data Sharing
- IPD Sharing
- Will share
Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.