NCT00041444

Brief Summary

To evaluate the relation of retinal microvascular characteristics to subclinical cardiovascular disease, clinical disease, and their risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6,176

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2002

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2002

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

July 8, 2002

Completed
1 day until next milestone

First Posted

Study publicly available on registry

July 9, 2002

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2006

Completed
Last Updated

February 8, 2016

Status Verified

February 1, 2016

Enrollment Period

4.4 years

First QC Date

July 8, 2002

Last Update Submit

February 5, 2016

Conditions

AtherosclerosisCardiovascular DiseasesCoronary ArteriosclerosisCoronary DiseaseCerebrovascular DisordersHeart Failure, CongestiveMyocardial InfarctionHeart DiseasesDiabetes Mellitus, Non-insulin DependentHypertensionDiabetic RetinopathyMacular DegenerationDiabetes Mellitus

Eligibility Criteria

Age45 Years - 84 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (30)

  • Klein R, Meuer SM, Moss SE, Klein BE, Neider MW, Reinke J. Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera. Arch Ophthalmol. 2004 Nov;122(11):1642-6. doi: 10.1001/archopht.122.11.1642.

    PMID: 15534124RESULT

  • Fernandez AB, Wong TY, Klein R, Collins D, Burke G, Cotch MF, Klein B, Sadeghi MM, Chen J. Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology. 2012 Apr;119(4):765-70. doi: 10.1016/j.ophtha.2011.09.044. Epub 2011 Dec 23.

    PMID: 22197438RESULT

  • Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O'Neill MS, Shrager S, Barr RG, Siscovick DS, Daviglus ML, Sampson PD, Kaufman JD. Air Pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based multi-ethnic study of atherosclerosis (MESA). PLoS Med. 2010 Nov 30;7(11):e1000372. doi: 10.1371/journal.pmed.1000372.

    PMID: 21152417RESULT

  • Cheung N, Sharrett AR, Klein R, Criqui MH, Islam FM, Macura KJ, Cotch MF, Klein BE, Wong TY. Aortic distensibility and retinal arteriolar narrowing: the multi-ethnic study of atherosclerosis. Hypertension. 2007 Oct;50(4):617-22. doi: 10.1161/HYPERTENSIONAHA.107.091926. Epub 2007 Aug 13.

    PMID: 17698721RESULT

  • Cheung N, Islam FM, Jacobs DR Jr, Sharrett AR, Klein R, Polak JF, Cotch MF, Klein BE, Ouyang P, Wong TY. Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ann Neurol. 2007 Dec;62(6):618-24. doi: 10.1002/ana.21236.

    PMID: 17918248RESULT

  • Klein R, Li X, Kuo JZ, Klein BE, Cotch MF, Wong TY, Taylor KD, Rotter JI. Associations of candidate genes to age-related macular degeneration among racial/ethnic groups in the multi-ethnic study of atherosclerosis. Am J Ophthalmol. 2013 Nov;156(5):1010-1020.e1. doi: 10.1016/j.ajo.2013.06.004. Epub 2013 Aug 12.

    PMID: 23938121RESULT

  • Wong TY, Klein R, Islam FM, Cotch MF, Folsom AR, Klein BE, Sharrett AR, Shea S. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol. 2006 Mar;141(3):446-455. doi: 10.1016/j.ajo.2005.08.063.

    PMID: 16490489RESULT

  • Klein R, Knudtson MD, Klein BE, Wong TY, Cotch MF, Barr G. Emphysema, airflow limitation, and early age-related macular degeneration. Arch Ophthalmol. 2010 Apr;128(4):472-7. doi: 10.1001/archophthalmol.2010.25.

    PMID: 20385944RESULT

  • Colagiuri S, Lee CM, Wong TY, Balkau B, Shaw JE, Borch-Johnsen K; DETECT-2 Collaboration Writing Group. Glycemic thresholds for diabetes-specific retinopathy: implications for diagnostic criteria for diabetes. Diabetes Care. 2011 Jan;34(1):145-50. doi: 10.2337/dc10-1206. Epub 2010 Oct 26.

    PMID: 20978099RESULT

  • Klein R, Knudtson MD, Klein BE, Wong TY, Cotch MF, Liu K, Cheng CY, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR. Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis. Ophthalmology. 2008 Oct;115(10):1742-9. doi: 10.1016/j.ophtha.2008.03.021. Epub 2008 Jun 5.

    PMID: 18538409RESULT

  • Nguyen TT, Alibrahim E, Islam FM, Klein R, Klein BE, Cotch MF, Shea S, Wong TY. Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis. Diabetes Care. 2009 Sep;32(9):1704-9. doi: 10.2337/dc09-0102. Epub 2009 Jun 23.

    PMID: 19549733RESULT

  • Kawasaki R, Cheung N, Islam FM, Klein R, Klein BE, Cotch MF, Sharrett AR, O'Leary D, Wong TY; Multi-Ethnic Study of Atherosclerosis. Is diabetic retinopathy related to subclinical cardiovascular disease? Ophthalmology. 2011 May;118(5):860-5. doi: 10.1016/j.ophtha.2010.08.040. Epub 2010 Dec 18.

    PMID: 21168222RESULT

  • Kreis AJ, Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Jenkins AJ, Shea S, Wang JJ. Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA). Diab Vasc Dis Res. 2009 Jan;6(1):40-2. doi: 10.3132/dvdr.2009.008.

    PMID: 19156628RESULT

  • Anuradha S, Healy GN, Dunstan DW, Klein R, Klein BE, Cotch MF, Wong TY, Owen N. Physical activity, television viewing time, and retinal microvascular caliber: the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2011 Mar 1;173(5):518-25. doi: 10.1093/aje/kwq412. Epub 2011 Feb 7.

    PMID: 21300854RESULT

  • Greenstein MB, Myers CE, Meuer SM, Klein BE, Cotch MF, Wong TY, Klein R. Prevalence and characteristics of choroidal nevi: the multi-ethnic study of atherosclerosis. Ophthalmology. 2011 Dec;118(12):2468-73. doi: 10.1016/j.ophtha.2011.05.007. Epub 2011 Aug 4.

    PMID: 21820181RESULT

  • Ng CH, Cheung N, Wang JJ, Islam AF, Kawasaki R, Meuer SM, Cotch MF, Klein BE, Klein R, Wong TY. Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology. 2011 Apr;118(4):694-9. doi: 10.1016/j.ophtha.2010.08.009. Epub 2010 Oct 29.

    PMID: 21035863RESULT

  • Klein R, Klein BE, Knudtson MD, Wong TY, Cotch MF, Liu K, Burke G, Saad MF, Jacobs DR Jr. Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology. 2006 Mar;113(3):373-80. doi: 10.1016/j.ophtha.2005.12.013.

    PMID: 16513455RESULT

  • Wong TY, Liew G, Tapp RJ, Schmidt MI, Wang JJ, Mitchell P, Klein R, Klein BE, Zimmet P, Shaw J. Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet. 2008 Mar 1;371(9614):736-43. doi: 10.1016/S0140-6736(08)60343-8.

    PMID: 18313502RESULT

  • Wong TY, Cheung N, Islam FM, Klein R, Criqui MH, Cotch MF, Carr JJ, Klein BE, Sharrett AR. Relation of retinopathy to coronary artery calcification: the multi-ethnic study of atherosclerosis. Am J Epidemiol. 2008 Jan 1;167(1):51-8. doi: 10.1093/aje/kwm256. Epub 2007 Sep 24.

    PMID: 17893402RESULT

  • Nguyen TT, Wang JJ, Sharrett AR, Islam FM, Klein R, Klein BE, Cotch MF, Wong TY. Relationship of retinal vascular caliber with diabetes and retinopathy: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2008 Mar;31(3):544-9. doi: 10.2337/dc07-1528. Epub 2007 Dec 10.

    PMID: 18070990RESULT

  • Cheung N, Bluemke DA, Klein R, Sharrett AR, Islam FM, Cotch MF, Klein BE, Criqui MH, Wong TY. Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis. J Am Coll Cardiol. 2007 Jul 3;50(1):48-55. doi: 10.1016/j.jacc.2007.03.029. Epub 2007 Jun 18.

    PMID: 17601545RESULT

  • Yau JW, Xie J, Lamoureux E, Klein R, Klein BE, Cotch MF, Bertoni AG, Shea S, Wong TY. Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes Res Clin Pract. 2012 Feb;95(2):265-74. doi: 10.1016/j.diabres.2011.10.027. Epub 2011 Nov 15.

    PMID: 22088792RESULT

  • Kawasaki R, Xie J, Cheung N, Lamoureux E, Klein R, Klein BE, Cotch MF, Sharrett AR, Shea S, Wong TY; MESA. Retinal microvascular signs and risk of stroke: the Multi-Ethnic Study of Atherosclerosis (MESA). Stroke. 2012 Dec;43(12):3245-51. doi: 10.1161/STROKEAHA.112.673335. Epub 2012 Oct 30.

    PMID: 23111439RESULT

  • Nguyen TT, Islam FM, Farouque HM, Klein R, Klein BE, Cotch MF, Herrington DM, Wong TY. Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke. 2010 Jul;41(7):1343-8. doi: 10.1161/STROKEAHA.110.581017. Epub 2010 May 27.

    PMID: 20508189RESULT

  • Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C, Sharrett AR, Shahar E. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2341-50. doi: 10.1167/iovs.05-1539.

    PMID: 16723443RESULT

  • Kawasaki R, Cheung N, Wang JJ, Klein R, Klein BE, Cotch MF, Sharrett AR, Shea S, Islam FA, Wong TY. Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis. J Hypertens. 2009 Dec;27(12):2386-93. doi: 10.1097/HJH.0b013e3283310f7e.

    PMID: 19680136RESULT

  • Ojaimi E, Nguyen TT, Klein R, Islam FM, Cotch MF, Klein BE, Wang JJ, Wong TY. Retinopathy signs in people without diabetes: the multi-ethnic study of atherosclerosis. Ophthalmology. 2011 Apr;118(4):656-62. doi: 10.1016/j.ophtha.2010.08.007. Epub 2010 Nov 4.

    PMID: 21055817RESULT

  • Klein R, Klein BE, Knudtson MD, Cotch MF, Wong TY, Liu K, Burke GL, Saad MF, Jacobs DR Jr, Sharrett AR. Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. Arch Ophthalmol. 2007 Apr;125(4):534-43. doi: 10.1001/archopht.125.4.534.

    PMID: 17420374RESULT

  • Cheung N, Klein R, Wang JJ, Cotch MF, Islam AF, Klein BE, Cushman M, Wong TY. Traditional and novel cardiovascular risk factors for retinal vein occlusion: the multiethnic study of atherosclerosis. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4297-302. doi: 10.1167/iovs.08-1826. Epub 2008 Jun 6.

    PMID: 18539932RESULT

  • Fisher DE, Shrager S, Shea SJ, Burke GL, Klein R, Wong TY, Klein BE, Cotch MF. Visual Impairment in White, Chinese, Black, and Hispanic Participants from the Multi-Ethnic Study of Atherosclerosis Cohort. Ophthalmic Epidemiol. 2015;22(5):321-32. doi: 10.3109/09286586.2015.1066395.

    PMID: 26395659RESULT

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesCoronary Artery DiseaseCoronary DiseaseCerebrovascular DisordersHeart FailureMyocardial InfarctionHeart DiseasesDiabetes Mellitus, Type 2HypertensionDiabetic RetinopathyMacular DegenerationDiabetes Mellitus

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial IschemiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesRetinal DiseasesEye DiseasesDiabetic AngiopathiesDiabetes ComplicationsRetinal Degeneration

Study Officials

  • Ronald Klein, MD, MPH

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 8, 2002

First Posted

July 9, 2002

Study Start

June 1, 2002

Primary Completion

November 1, 2006

Study Completion

November 1, 2006

Last Updated

February 8, 2016

Record last verified: 2016-02