A Study of Peer Education to Prevent HIV Transmission Among Injection Drug Users and Their HIV Risk Contacts
A Phase III Randomized Study to Evaluate the Efficacy of a Network-Oriented Peer Education Intervention for the Prevention of HIV Transmission Among Injection Drug Users and Their Network Members
1 other identifier
interventional
2,610
2 countries
3
Brief Summary
Injection drug use is the major mode of HIV transmission in many countries. Injection drug users (IDUs) transmit HIV not only through shared drug injection equipment but also through heterosexual and homosexual transmission and mother-to-child transmission. Studies have shown that peer education programs can reduce HIV risk behavior in IDUs. However, it is not known if reduced HIV risk behavior leads to fewer HIV infections. The purpose of this study is to find out if a peer education program can reduce the number of new HIV infections by changing the behavior of IDUs and their HIV risk contacts.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 hiv-infections
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 4, 2002
CompletedFirst Posted
Study publicly available on registry
June 5, 2002
CompletedOctober 30, 2009
March 1, 2006
June 4, 2002
October 29, 2009
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- HIV uninfected within 60 days of study entry
- Injected drugs at least 12 times in the last 3 months
- Out of methadone maintenance treatment for at least 3 months and have relapsed
- Willing to identify and attempt to recruit at least two HIV risk network members who are eligible for study
- Able to recruit at least one HIV risk network member eligible for study participation
- Recruited by an eligible index participant for the study
- Have injected drugs with and/or had sex with the relevant index participant within 3 months prior to screening
You may not qualify if:
- For index participants: prior or concurrent enrollment in another HIV behavioral or biomedical prevention study (e.g., vaccine or microbicide research, or any other behavioral or clinical research to test an intervention aimed at preventing or reducing the risk of HIV infection)
- Already enrolled in another network of HPTN 037 as a network member or index participant
- Mental, learning, or any other problems that would interfere with the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Univ of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
RAP Office
Philadelphia, Pennsylvania, 19123, United States
Research Institute for Health Sciences
Chiang Mai, 50202, Thailand
Related Publications (8)
Needle RH, Coyle SL, Normand J, Lambert E, Cesari H. HIV prevention with drug-using populations--current status and future prospects: introduction and overview. Public Health Rep. 1998 Jun;113 Suppl 1(Suppl 1):4-18. No abstract available.
PMID: 9722806BACKGROUNDRietmeijer CA, Kane MS, Simons PZ, Corby NH, Wolitski RJ, Higgins DL, Judson FN, Cohn DL. Increasing the use of bleach and condoms among injecting drug users in Denver: outcomes of a targeted, community-level HIV prevention program. AIDS. 1996 Mar;10(3):291-8.
PMID: 8882669BACKGROUNDLatkin CA, Mandell W, Vlahov D, Oziemkowska M, Celentano DD. The long-term outcome of a personal network-oriented HIV prevention intervention for injection drug users: the SAFE Study. Am J Community Psychol. 1996 Jun;24(3):341-64. doi: 10.1007/BF02512026.
PMID: 8864208BACKGROUNDKamb ML, Fishbein M, Douglas JM Jr, Rhodes F, Rogers J, Bolan G, Zenilman J, Hoxworth T, Malotte CK, Iatesta M, Kent C, Lentz A, Graziano S, Byers RH, Peterman TA. Efficacy of risk-reduction counseling to prevent human immunodeficiency virus and sexually transmitted diseases: a randomized controlled trial. Project RESPECT Study Group. JAMA. 1998 Oct 7;280(13):1161-7. doi: 10.1001/jama.280.13.1161.
PMID: 9777816BACKGROUNDLatkin CA, Sherman S, Knowlton A. HIV prevention among drug users: outcome of a network-oriented peer outreach intervention. Health Psychol. 2003 Jul;22(4):332-9. doi: 10.1037/0278-6133.22.4.332.
PMID: 12940388BACKGROUNDLatkin CA, Forman V, Knowlton A, Sherman S. Norms, social networks, and HIV-related risk behaviors among urban disadvantaged drug users. Soc Sci Med. 2003 Feb;56(3):465-76. doi: 10.1016/s0277-9536(02)00047-3.
PMID: 12570967BACKGROUNDHernandez-Ramirez RU, Spiegelman D, Lok JJ, Forastiere L, Friedman SR, Latkin CA, Vermund SH, Buchanan AL. Overall, Direct, Spillover, and Composite Effects of Components of a Peer-Driven Intervention Package on Injection Risk Behavior Among People Who Inject Drugs in the HPTN 037 Study. AIDS Behav. 2024 Jan;28(1):225-237. doi: 10.1007/s10461-023-04213-x. Epub 2023 Nov 7.
PMID: 37932493DERIVEDLatkin C, Donnell D, Liu TY, Davey-Rothwell M, Celentano D, Metzger D. The dynamic relationship between social norms and behaviors: the results of an HIV prevention network intervention for injection drug users. Addiction. 2013 May;108(5):934-43. doi: 10.1111/add.12095. Epub 2013 Jan 30.
PMID: 23362861DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Carl Latkin, PhD
Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University