Effect of Ventilation-Feedback Training on Exercise Performance in COPD

NCT00037973 | Completed Phase 2

• 1 other identifier: F2302
• Study Type: interventional
• Target: 108
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of the study is to determine whether individuals with Chronic Obstructive Pulmonary Disease (COPD) who complete ventilation-feedback training combined with a moderately-high intensity exercise and upper body strength program will demonstrate significantly longer exercise duration on a constant work rate treadmill test when compared to subjects who are randomly assigned to a moderately-high intensity exercise and upper body strength training program without ventilation-feedback or ventilation-feedback only. Secondary study objectives are to determine whether individuals with COPD who complete ventilation-feedback training combined with a moderately-high intensity exercise and upper body strength training program will demonstrate significantly: (a) greater exercise tolerance and aerobic power; (b) lower perception of breathlessness during progressive and constant work rate leg-cycle and treadmill exercise testing; (c) higher tidal volume and lower breathing frequency during constant work rate and at any given workload during progressive testing; (d) lower score on the Chronic Respiratory Disease Questionnaire indicating improved quality of life; (e) higher transition focal score (less dyspnea) on the Transition Dyspnea Index; (f) maintain a sustained breathing-pattern adjustment to exercise when compared to subjects who are randomly assigned to a moderately-high intensity exercise and upper body strength program without ventilation-feedback or ventilation-feedback only.

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

COPD; Ventilation

Outcome Measures

Primary Outcomes (1)

• Exercise endurance

  12 weeks

Study Arms (3)

1

EXPERIMENTAL

Ventilation-feedback plus exercise

Behavioral: ventilation feedback; Behavioral: exercise

2

ACTIVE COMPARATOR

Exercise

Behavioral: exercise

3

ACTIVE COMPARATOR

ventilation feedback only

Behavioral: ventilation feedback

Interventions

ventilation feedback BEHAVIORAL

1; 3

exercise BEHAVIORAL

1; 2

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with chronic obstructive pulmonary disease

Sponsors & Collaborators

• US Department of Veterans Affairs: lead

Study Sites (1)

Edward Hines, Jr. VA Hospital

Hines, Illinois, 60141-5000, United States

Location

Related Publications (1)

• Collins EG, Langbein WE, Fehr L, O'Connell S, Jelinek C, Hagarty E, Edwards L, Reda D, Tobin MJ, Laghi F. Can ventilation-feedback training augment exercise tolerance in patients with chronic obstructive pulmonary disease? Am J Respir Crit Care Med. 2008 Apr 15;177(8):844-52. doi: 10.1164/rccm.200703-477OC. Epub 2008 Jan 17.

  PMID: 18202351 RESULT

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Respiratory Aspiration

Interventions

Exercise

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Eileen G. Collins, PhD RN

  Edward Hines Jr. VA Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED

Study Record Dates

• First Submitted: May 24, 2002
• First Posted: May 27, 2002
• Study Start: August 1, 2000
• Primary Completion: August 1, 2003
• Study Completion: August 1, 2003
• Last Updated: September 16, 2010

Record last verified: 2010-09

Locations

US (1)