NCT00028353

Brief Summary

If you are a male 30 years of age or older and have a positive diagnosis of high grade (II or III) prostate Intraepithelial Neoplasia (PIN) or have had an abnormal/suspicious prostate biopsy, you may be eligible for this study. This is a study of an investigational medication that may reduce high grade PIN and prevent the occurrence of prostate cancer. This study is currently enrolling up to 500 men at approximately 60 locations in the United States.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Apr 2001

Geographic Reach
1 country

25 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2001

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

December 22, 2001

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 24, 2001

Completed
1.5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2003

Completed
Last Updated

November 15, 2013

Status Verified

November 1, 2013

First QC Date

December 22, 2001

Last Update Submit

November 13, 2013

Conditions

Keywords

PINHigh Grade Prostate Intraepithelial Neoplasia (PIN)

Interventions

Eligibility Criteria

Age30 Years+
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
* Must have confirmed high grade PIN on prostate biopsy within past 6 months. * Must have a serum PSA \<12 ng/ml. * Can not have prostate cancer. * Have significant ocular opacities. * Can not take finasteride or other testosterone like supplement.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (25)

Private Practice

Huntsville, Alabama, 35801, United States

Location

Arkansas Urology Associates

Little Rock, Arkansas, 72211, United States

Location

South Florida Medical Research

Aventura, Florida, 33180, United States

Location

UroSearch

Leesburg, Florida, 34748, United States

Location

The Urology Center of Florida Inc.

Ocala, Florida, 34474, United States

Location

UroSearch

Ocala, Florida, 34474, United States

Location

Dr. Byron Hodge

Orlando, Florida, 32806, United States

Location

H. Lee Moffitt Cancer Center

Tampa, Florida, 33612-9497, United States

Location

Sandy Springs Urology, P.C.

Atlanta, Georgia, 30328, United States

Location

North Idaho Urology

Couer D'Alene, Idaho, 83814, United States

Location

Wishard Memorial Hospital

Indianapolis, Indiana, 46202, United States

Location

Mid Atlantic Clinical Research

Rockville, Maryland, 20850, United States

Location

Newton Wellesley Urology

Newton, Massachusetts, 02162, United States

Location

Private Practice

Las Vegas, Nevada, 89109, United States

Location

Medical & Clinical Research Associates

Bay Shore, New York, 11706, United States

Location

Clinical Research of Westchester

New Rochelle, New York, 10801, United States

Location

Columbia University

New York, New York, 10032, United States

Location

Private Practice

Staten Island, New York, 10305, United States

Location

Salem Research Group, Inc.

Winston-Salem, North Carolina, 27103, United States

Location

Tri-State Urologic Services

Cincinnati, Ohio, 45212, United States

Location

Urologic Surgery, P.C

Bala-Cynwyd, Pennsylvania, 19004, United States

Location

Urology Associates of Lancaster

Lancaster, Pennsylvania, 17604, United States

Location

Urology San Antonio Research

San Antonio, Texas, 78229, United States

Location

Seattle Urological Associates

Seattle, Washington, 98104, United States

Location

Madigan Army Medical Center

Tacoma, Washington, 98431, United States

Location

Related Links

MeSH Terms

Conditions

Prostatic Intraepithelial Neoplasia

Interventions

Toremifene

Condition Hierarchy (Ancestors)

Carcinoma in SituCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasms

Intervention Hierarchy (Ancestors)

TamoxifenStilbenesBenzylidene CompoundsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic Chemicals

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

December 22, 2001

First Posted

December 24, 2001

Study Start

April 1, 2001

Study Completion

July 1, 2003

Last Updated

November 15, 2013

Record last verified: 2013-11

Locations