A Study of Decreased Mental Function Associated With HIV
HIV-Associated Cognitive Impairment and Oxidative Stress: An In Vivo Proton Magnetic Resonance Spectroscopy Study of Cerebral Injury
3 other identifiers
interventional
90
1 country
12
Brief Summary
The purpose of this study is to compare pictures of the brain of HIV-infected people with memory problems before and after treatment with selegiline. Selegiline is the study drug received through A5090. HIV patients generally develop memory problems late in the disease. This will be examined using noninvasive proton magnetic resonance spectroscopy (1H-MRS). The effect of the drug selegiline on memory problems also will be examined.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 16, 2001
CompletedFirst Posted
Study publicly available on registry
November 19, 2001
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2005
CompletedJanuary 16, 2015
October 1, 2012
November 16, 2001
January 15, 2015
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- Patients may be eligible for this study if they:
- Are enrolled in ACTG protocol A5090.
You may not qualify if:
- Patients will not be eligible for this study if they have:
- Claustrophobia (unless sedation with lorazepam or zolpidem allows for safe performance of the MRS).
- Metallic implants/medical devices (e.g., skull implants or cardiac devices).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (12)
UCLA CARE Ctr
Los Angeles, California, 90095, United States
Univ of California, San Diego
San Diego, California, 92103, United States
Stanford University
Stanford, California, 94305-5107, United States
Johns Hopkins Hosp
Baltimore, Maryland, 21287, United States
Mount Sinai Med Ctr
New York, New York, 10029, United States
Columbia Presbyterian Med Ctr
New York, New York, 10032, United States
Univ of Rochester Medical Center
Rochester, New York, 14642, United States
Univ of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Rhode Island Hosp
Providence, Rhode Island, 02906, United States
Stanley Street Treatment and Resource
Providence, Rhode Island, 02906, United States
The Miriam Hosp
Providence, Rhode Island, 02906, United States
Univ of Washington
Seattle, Washington, 98104, United States
Related Publications (1)
Schifitto G, Yiannoutsos CT, Ernst T, Navia BA, Nath A, Sacktor N, Anderson C, Marra CM, Clifford DB; ACTG 5114 Team. Selegiline and oxidative stress in HIV-associated cognitive impairment. Neurology. 2009 Dec 8;73(23):1975-81. doi: 10.1212/WNL.0b013e3181c51a48. Epub 2009 Nov 4.
PMID: 19890073RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Giovanni Schifitto
- STUDY CHAIR
Bradford Navia
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Purpose
- TREATMENT
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 16, 2001
First Posted
November 19, 2001
Study Completion
June 1, 2005
Last Updated
January 16, 2015
Record last verified: 2012-10