Multidisciplinary Study of Right Ventricular Dysplasia

NCT00024505 | Completed DMC

• 5 other identifiers: 983U01HL065594-05U01HL065594U01HL065652U01HL065691
• Study Type: observational
• Target: 320
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the cardiac, clinical, and genetic aspects of arrhythmogenic right ventricular dysplasia (ARVD), a progressive disorder that predominantly affects the right side of the heart and causes ventricular arrhythmias.

Conditions

Heart Diseases; Arrhythmogenic Right Ventricular Dysplasia

Outcome Measures

Primary Outcomes (1)

• Identifying the cardiac, clinical, and genetic aspects of ARVD

  Measured during the course of the study

Eligibility Criteria

• Age: 12 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Referals to enrolling centers from communities

You may qualify if:

• Males and females over the age of puberty
• Suspected ARVD based on the presence of major or minor Task Force Criteria

You may not qualify if:

• Children younger than 12 years of age
• Internal cardioverter defibrillator (ICD) in place for more than 2 years (for probands)
• Individuals with monomorphic ventricular ectopy of predominantly RBBB morphology
• Individuals with obvious cardiomyopathic abnormalities of structure or function predominantly affecting the left ventricle
• Individuals with other conditions that might be mistaken for right ventricular dysplasia such as congenital heart disease, e.g., atrial septal defect, anomalous drainage of the pulmonary vessels into the right atrium, and Ebstein's malformation
• Individuals unwilling to undergo diagnostic testing at the nearest enrolling center

Sponsors & Collaborators

• University of Arizona: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of Arizona

Tucson, Arizona, 85724, United States

Location

Related Publications (53)

• Marcus F, Towbin JA, Zareba W, Moss A, Calkins H, Brown M, Gear K; ARVD/C Investigators. Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C): a multidisciplinary study: design and protocol. Circulation. 2003 Jun 17;107(23):2975-8. doi: 10.1161/01.CIR.0000071380.43086.29. No abstract available.

  PMID: 12814984 BACKGROUND

• Yoerger DM, Marcus F, Sherrill D, Calkins H, Towbin JA, Zareba W, Picard MH; Multidisciplinary Study of Right Ventricular Dysplasia Investigators. Echocardiographic findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia: new insights from the multidisciplinary study of right ventricular dysplasia. J Am Coll Cardiol. 2005 Mar 15;45(6):860-5. doi: 10.1016/j.jacc.2004.10.070.

  PMID: 15766820 BACKGROUND

• Scheinman MM, Crawford MH. Echocardiographic findings and the search for a gold standard in patients with arrhythmogenic right ventricular dysplasia. J Am Coll Cardiol. 2005 Mar 15;45(6):866-7. doi: 10.1016/j.jacc.2004.12.021. No abstract available.

  PMID: 15766821 BACKGROUND

• Indik JH, Dallas WJ, Ovitt T, Wichter T, Gear K, Marcus FI. Do patients with right ventricular outflow tract ventricular arrhythmias have a normal right ventricular wall motion? A quantitative analysis compared to normal subjects. Cardiology. 2005;104(1):10-5. doi: 10.1159/000086047. Epub 2005 May 28.

  PMID: 15942177 BACKGROUND

• Dalal D, Nasir K, Bomma C, Prakasa K, Tandri H, Piccini J, Roguin A, Tichnell C, James C, Russell SD, Judge DP, Abraham T, Spevak PJ, Bluemke DA, Calkins H. Arrhythmogenic right ventricular dysplasia: a United States experience. Circulation. 2005 Dec 20;112(25):3823-32. doi: 10.1161/CIRCULATIONAHA.105.542266. Epub 2005 Dec 12.

  PMID: 16344387 BACKGROUND

• Bowles NE, Ni J, Marcus F, Towbin JA. The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol. 2002 Mar 6;39(5):892-5. doi: 10.1016/s0735-1097(02)01688-1.

  PMID: 11869858 BACKGROUND

• Rampazzo A, Nava A, Malacrida S, Beffagna G, Bauce B, Rossi V, Zimbello R, Simionati B, Basso C, Thiene G, Towbin JA, Danieli GA. Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2002 Nov;71(5):1200-6. doi: 10.1086/344208. Epub 2002 Oct 8.

  PMID: 12373648 BACKGROUND

• Rampazzo A, Beffagna G, Nava A, Occhi G, Bauce B, Noiato M, Basso C, Frigo G, Thiene G, Towbin J, Danieli GA. Arrhythmogenic right ventricular cardiomyopathy type 1 (ARVD1): confirmation of locus assignment and mutation screening of four candidate genes. Eur J Hum Genet. 2003 Jan;11(1):69-76. doi: 10.1038/sj.ejhg.5200914.

  PMID: 12529708 BACKGROUND

• Gear K, Marcus F. Arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circulation. 2003 Feb 4;107(4):e31-3. doi: 10.1161/01.cir.0000053943.38763.70. No abstract available.

  PMID: 12569915 BACKGROUND

• Nasir K, Tandri H, Rutberg J, Tichnell C, Spevak P, Crossan J, Baughman KL, Kasper EK, Tomaselli GF, Berger R, Calkins H. Filtered QRS duration on signal-averaged electrocardiography predicts inducibility of ventricular tachycardia in arrhythmogenic right ventricle dysplasia. Pacing Clin Electrophysiol. 2003 Oct;26(10):1955-60. doi: 10.1046/j.1460-9592.2003.00302.x.

  PMID: 14516335 BACKGROUND

• Tandri H, Friedrich MG, Calkins H, Bluemke DA. MRI of arrhythmogenic right ventricular cardiomyopathy/dysplasia. J Cardiovasc Magn Reson. 2004;6(2):557-63. doi: 10.1081/jcmr-120030583.

  PMID: 15137340 BACKGROUND

• Tandri H, Bomma C, Calkins H, Bluemke DA. Magnetic resonance and computed tomography imaging of arrhythmogenic right ventricular dysplasia. J Magn Reson Imaging. 2004 Jun;19(6):848-58. doi: 10.1002/jmri.20078.

  PMID: 15170788 BACKGROUND

• Castillo E, Tandri H, Rodriguez ER, Nasir K, Rutberg J, Calkins H, Lima JA, Bluemke DA. Arrhythmogenic right ventricular dysplasia: ex vivo and in vivo fat detection with black-blood MR imaging. Radiology. 2004 Jul;232(1):38-48. doi: 10.1148/radiol.2321030688.

  PMID: 15220492 BACKGROUND

• Tandri H, Bluemke DA, Ferrari VA, Bomma C, Nasir K, Rutberg J, Tichnell C, James C, Lima JA, Calkins H. Findings on magnetic resonance imaging of idiopathic right ventricular outflow tachycardia. Am J Cardiol. 2004 Dec 1;94(11):1441-5. doi: 10.1016/j.amjcard.2004.07.150.

  PMID: 15566923 BACKGROUND

• Roguin A, Bomma CS, Nasir K, Tandri H, Tichnell C, James C, Rutberg J, Crosson J, Spevak PJ, Berger RD, Halperin HR, Calkins H. Implantable cardioverter-defibrillators in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol. 2004 May 19;43(10):1843-52. doi: 10.1016/j.jacc.2004.01.030.

  PMID: 15145110 BACKGROUND

• Basso C, Fox PR, Meurs KM, Towbin JA, Spier AW, Calabrese F, Maron BJ, Thiene G. Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease. Circulation. 2004 Mar 9;109(9):1180-5. doi: 10.1161/01.CIR.0000118494.07530.65. Epub 2004 Mar 1.

  PMID: 14993138 BACKGROUND

• Rossi V, Beffagna G, Rampazzo A, Bauce B, Danieli GA. TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region. Gene. 2004 Jun 23;335:101-8. doi: 10.1016/j.gene.2004.03.008.

  PMID: 15194193 BACKGROUND

• Tandri H, Saranathan M, Rodriguez ER, Martinez C, Bomma C, Nasir K, Rosen B, Lima JA, Calkins H, Bluemke DA. Noninvasive detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement magnetic resonance imaging. J Am Coll Cardiol. 2005 Jan 4;45(1):98-103. doi: 10.1016/j.jacc.2004.09.053.

  PMID: 15629382 BACKGROUND

• Marcus FI. Prevalence of T-wave inversion beyond V1 in young normal individuals and usefulness for the diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia. Am J Cardiol. 2005 May 1;95(9):1070-1. doi: 10.1016/j.amjcard.2004.12.060.

  PMID: 15842973 BACKGROUND

• Beffagna G, Occhi G, Nava A, Vitiello L, Ditadi A, Basso C, Bauce B, Carraro G, Thiene G, Towbin JA, Danieli GA, Rampazzo A. Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1. Cardiovasc Res. 2005 Feb 1;65(2):366-73. doi: 10.1016/j.cardiores.2004.10.005.

  PMID: 15639475 BACKGROUND

• Ainsworth CD, Skanes AC, Klein GJ, Gula LJ, Yee R, Krahn AD. Differentiating arrhythmogenic right ventricular cardiomyopathy from right ventricular outflow tract ventricular tachycardia using multilead QRS duration and axis. Heart Rhythm. 2006 Apr;3(4):416-23. doi: 10.1016/j.hrthm.2005.12.024.

  PMID: 16567288 BACKGROUND

• Altbach MI, Li Z, Bilgin A, Marcus FI, Sorrell VL, Gmitro AF, Bluemke DA. Interleaved acquisition of lipid and water images of the heart using a double-inversion fast spin-echo method. Magn Reson Med. 2005 Dec;54(6):1562-8. doi: 10.1002/mrm.20691.

  PMID: 16217777 BACKGROUND

• Dalal D, Molin LH, Piccini J, Tichnell C, James C, Bomma C, Prakasa K, Towbin JA, Marcus FI, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP. Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2. Circulation. 2006 Apr 4;113(13):1641-9. doi: 10.1161/CIRCULATIONAHA.105.568642. Epub 2006 Mar 20.

  PMID: 16549640 BACKGROUND

• Piccini JP, Dalal D, Roguin A, Bomma C, Cheng A, Prakasa K, Dong J, Tichnell C, James C, Russell S, Crosson J, Berger RD, Marine JE, Tomaselli G, Calkins H. Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia. Heart Rhythm. 2005 Nov;2(11):1188-94. doi: 10.1016/j.hrthm.2005.08.022.

  PMID: 16253908 BACKGROUND

• Awad MM, Dalal D, Cho E, Amat-Alarcon N, James C, Tichnell C, Tucker A, Russell SD, Bluemke DA, Dietz HC, Calkins H, Judge DP. DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Hum Genet. 2006 Jul;79(1):136-42. doi: 10.1086/504393. Epub 2006 Apr 28.

  PMID: 16773573 BACKGROUND

• Pilichou K, Nava A, Basso C, Beffagna G, Bauce B, Lorenzon A, Frigo G, Vettori A, Valente M, Towbin J, Thiene G, Danieli GA, Rampazzo A. Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation. 2006 Mar 7;113(9):1171-9. doi: 10.1161/CIRCULATIONAHA.105.583674. Epub 2006 Feb 27.

  PMID: 16505173 BACKGROUND

• Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006 Sep 15;99(6):646-55. doi: 10.1161/01.RES.0000241482.19382.c6. Epub 2006 Aug 17.

  PMID: 16917092 BACKGROUND

• Piotrowicz K, Couderc JP, Towbin JA, Marcus F, Zareba W.. Repolarization dynamics and heart rate variability in patients with ARVD. Heart Rhythm 2005;2(1S)S223

  BACKGROUND

• Tandri H, Rutberg J, Bluemke DA, Calkins H. Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia. J Cardiovasc Electrophysiol. 2002 Nov;13(11):1180. doi: 10.1046/j.1540-8167.2002.01180.x. No abstract available.

  PMID: 12475115 BACKGROUND

• Nasir K, Rutberg J, Tandri H, Berger R, Tomaselli G, Calkins H. Utility of SAECG in arrhythmogenic right ventricle dysplasia. Ann Noninvasive Electrocardiol. 2003 Apr;8(2):112-20. doi: 10.1046/j.1542-474x.2003.08204.x.

  PMID: 12848791 BACKGROUND

• Tandri H, Calkins H, Nasir K, Bomma C, Castillo E, Rutberg J, Tichnell C, Lima JA, Bluemke DA. Magnetic resonance imaging findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia. J Cardiovasc Electrophysiol. 2003 May;14(5):476-82. doi: 10.1046/j.1540-8167.2003.02560.x.

  PMID: 12776863 BACKGROUND

• Bomma C, Rutberg J, Tandri H, Nasir K, Roguin A, Tichnell C, Rodriguez R, James C, Kasper E, Spevak P, Bluemke DA, Calkins H. Misdiagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Cardiovasc Electrophysiol. 2004 Mar;15(3):300-6. doi: 10.1046/j.1540-8167.2004.03429.x.

  PMID: 15030420 BACKGROUND

• Bomma C, Dalal D, Tandri H, Prakasa K, Nasir K, Roguin A, Tichnell C, James C, Lima JA, Calkins H, Bluemke DA. Regional differences in systolic and diastolic function in arrhythmogenic right ventricular dysplasia/cardiomyopathy using magnetic resonance imaging. Am J Cardiol. 2005 Jun 15;95(12):1507-11. doi: 10.1016/j.amjcard.2005.02.026.

  PMID: 15950585 BACKGROUND

• Fritz J, Solaiyappan M, Tandri H, Bomma C, Genc A, Claussen CD, Lima JA, Bluemke DA. Right ventricle shape and contraction patterns and relation to magnetic resonance imaging findings. J Comput Assist Tomogr. 2005 Nov-Dec;29(6):725-33. doi: 10.1097/01.rct.0000179596.86221.38.

  PMID: 16272840 BACKGROUND

• Dalal D, James C, Devanagondi R, Tichnell C, Tucker A, Prakasa K, Spevak PJ, Bluemke DA, Abraham T, Russell SD, Calkins H, Judge DP. Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol. 2006 Oct 3;48(7):1416-24. doi: 10.1016/j.jacc.2006.06.045. Epub 2006 Sep 12.

  PMID: 17010805 BACKGROUND

• Prakasa KR, Dalal D, Wang J, Bomma C, Tandri H, Dong J, James C, Tichnell C, Russell SD, Spevak P, Corretti M, Bluemke DA, Calkins H, Abraham TP. Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2006 Mar 1;97(5):703-9. doi: 10.1016/j.amjcard.2005.11.020. Epub 2006 Jan 13.

  PMID: 16490442 BACKGROUND

• Marcus F, Towbin JA. The mystery of arrhythmogenic right ventricular dysplasia/cardiomyopathy: from observation to mechanistic explanation. Circulation. 2006 Oct 24;114(17):1794-5. doi: 10.1161/CIRCULATIONAHA.106.653493. No abstract available.

  PMID: 17060394 BACKGROUND

• Tandri H, Castillo E, Ferrari VA, Nasir K, Dalal D, Bomma C, Calkins H, Bluemke DA. Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia: sensitivity, specificity, and observer variability of fat detection versus functional analysis of the right ventricle. J Am Coll Cardiol. 2006 Dec 5;48(11):2277-84. doi: 10.1016/j.jacc.2006.07.051.

  PMID: 17161260 BACKGROUND

• Marcus FI, Zareba W, Sherrill D. Evaluation of the normal values for signal-averaged electrocardiogram. J Cardiovasc Electrophysiol. 2007 Feb;18(2):231-3. doi: 10.1111/j.1540-8167.2006.00685.x. No abstract available.

  PMID: 17338774 BACKGROUND

• Tandri H, Daya SK, Nasir K, Bomma C, Lima JA, Calkins H, Bluemke DA. Normal reference values for the adult right ventricle by magnetic resonance imaging. Am J Cardiol. 2006 Dec 15;98(12):1660-4. doi: 10.1016/j.amjcard.2006.07.049. Epub 2006 Oct 27.

  PMID: 17145230 BACKGROUND

• Vatta M, Marcus F, Towbin JA. Arrhythmogenic right ventricular cardiomyopathy: a 'final common pathway' that defines clinical phenotype. Eur Heart J. 2007 Mar;28(5):529-30. doi: 10.1093/eurheartj/ehl530. Epub 2007 Feb 15. No abstract available.

  PMID: 17303588 BACKGROUND

• Bomma C, Dalal D, Tandri H, Prakasa K, Nasir K, Roguin A, Piccini J, Dong J, Mahadevappa M, Tichnell C, James C, Lima JA, Fishman E, Calkins H, Bluemke DA. Evolving role of multidetector computed tomography in evaluation of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Jul 1;100(1):99-105. doi: 10.1016/j.amjcard.2007.02.064. Epub 2007 May 21.

  PMID: 17599449 BACKGROUND

• Dalal D, Jain R, Tandri H, Dong J, Eid SM, Prakasa K, Tichnell C, James C, Abraham T, Russell SD, Sinha S, Judge DP, Bluemke DA, Marine JE, Calkins H. Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol. 2007 Jul 31;50(5):432-40. doi: 10.1016/j.jacc.2007.03.049. Epub 2007 Jul 16.

  PMID: 17662396 BACKGROUND

• Prakasa KR, Wang J, Tandri H, Dalal D, Bomma C, Chojnowski R, James C, Tichnell C, Russell S, Judge D, Corretti M, Bluemke D, Calkins H, Abraham TP. Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Am J Cardiol. 2007 Aug 1;100(3):507-12. doi: 10.1016/j.amjcard.2007.03.053. Epub 2007 Jun 15.

  PMID: 17659937 BACKGROUND

• Wang J, Prakasa K, Bomma C, Tandri H, Dalal D, James C, Tichnell C, Corretti M, Bluemke D, Calkins H, Abraham TP. Comparison of novel echocardiographic parameters of right ventricular function with ejection fraction by cardiac magnetic resonance. J Am Soc Echocardiogr. 2007 Sep;20(9):1058-64. doi: 10.1016/j.echo.2007.01.038. Epub 2007 Jun 6.

  PMID: 17555927 BACKGROUND

• Tandri H, Macedo R, Calkins H, Marcus F, Cannom D, Scheinman M, Daubert J, Estes M 3rd, Wilber D, Talajic M, Duff H, Krahn A, Sweeney M, Garan H, Bluemke DA; Multidisciplinary Study of Right Ventricular Dysplasia Investigators. Role of magnetic resonance imaging in arrhythmogenic right ventricular dysplasia: insights from the North American arrhythmogenic right ventricular dysplasia (ARVD/C) study. Am Heart J. 2008 Jan;155(1):147-53. doi: 10.1016/j.ahj.2007.08.011. Epub 2007 Sep 14.

  PMID: 18082506 BACKGROUND

• Indik JH, Wichter T, Gear K, Dallas WJ, Marcus FI. Quantitative assessment of angiographic right ventricular wall motion in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). J Cardiovasc Electrophysiol. 2008 Jan;19(1):39-45. doi: 10.1111/j.1540-8167.2007.00974.x. Epub 2007 Sep 24.

  PMID: 17900252 BACKGROUND

• Jain A, Tandri H, Calkins H, Bluemke DA. Role of cardiovascular magnetic resonance imaging in arrhythmogenic right ventricular dysplasia. J Cardiovasc Magn Reson. 2008 Jun 20;10(1):32. doi: 10.1186/1532-429X-10-32.

  PMID: 18570661 BACKGROUND

• Ly S, Marcus FI, Xu T, Towbin JA. A woman with incidental findings of ventricular aneurysms and a desmosomal cardiomyopathy. Heart Rhythm. 2008 Oct;5(10):1455-7. doi: 10.1016/j.hrthm.2008.05.025. Epub 2008 May 29. No abstract available.

  PMID: 18672408 BACKGROUND

• Zareba W, Marcus F, Calkins H,; Piotrowicz K, McNitt S. Importance of ECG Presentation of Newly Identified ARVD Probands - Findings from the North American ARVD Registry Circ 114(18):II-706 2006

  RESULT

• Ruwald AC, Marcus F, Estes NA 3rd, Link M, McNitt S, Polonsky B, Calkins H, Towbin JA, Moss AJ, Zareba W. Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 2015 Jul 14;36(27):1735-43. doi: 10.1093/eurheartj/ehv110. Epub 2015 Apr 20.

  PMID: 25896080 DERIVED

• Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J. 2010 Apr;31(7):806-14. doi: 10.1093/eurheartj/ehq025. Epub 2010 Feb 19.

  PMID: 20172912 DERIVED

• Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation. 2010 Apr 6;121(13):1533-41. doi: 10.1161/CIRCULATIONAHA.108.840827. Epub 2010 Feb 19.

  PMID: 20172911 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Heart Diseases; Arrhythmogenic Right Ventricular Dysplasia

Condition Hierarchy (Ancestors)

Cardiovascular Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiomyopathies; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Frank I. Marcus, MD

  University of Arizona

  PRINCIPAL INVESTIGATOR

• Jeffrey Towbin

  Baylor College of Medicine

  PRINCIPAL INVESTIGATOR

• Wojciech Zareba

  University of Rochester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Emeritus

Study Record Dates

• First Submitted: September 18, 2001
• First Posted: September 18, 2001
• Study Start: September 1, 2001
• Primary Completion: July 1, 2010
• Study Completion: July 1, 2010
• Last Updated: January 17, 2013

Record last verified: 2013-01

Locations

US (1)