Digital Mammography Screening Trial (ACRIN6652)
DMIST
Screening and Diagnostic Trial to Compare the Effectiveness of Two Types of Mammography in Detecting Breast Cancer in Women
4 other identifiers
interventional
49,528
2 countries
32
Brief Summary
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for cancer. It is not yet known which type of mammography is more effective in detecting breast cancer. PURPOSE: Screening and diagnostic trial to compare the effectiveness of two types of mammography in detecting breast cancer in women.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable breast-cancer
Started Oct 2001
Typical duration for not_applicable breast-cancer
32 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 6, 2001
CompletedStudy Start
First participant enrolled
October 1, 2001
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2005
CompletedJuly 11, 2017
July 1, 2017
3.3 years
January 6, 2001
July 7, 2017
Conditions
Keywords
Study Arms (2)
SFM then FFDM
OTHERScreen Film Mammography (SFM) followed by Full Field Digital Mammography (FFDM)
FFDM then SFM
OTHERFull Field Digital Mammography (FFDM) followed by Screen Film Mammography (SFM)
Interventions
Radiologic test to screen women for Breast cancer using digital detectors
Radiologic test to screen women for Breast cancer using plain film detectors a resolution screen
Eligibility Criteria
You may not qualify if:
- All women who have breast implants. 4.2.3 Any woman who is pregnant or has reason to believe that she might be pregnant.
- Participants who cannot, for any reason, undergo follow-up screen-film mammography at the participating institution or provide mammograms from another institution for review for one year after study entry.
- All women with a history of breast cancer treated with lumpectomy. Note: Women with a history of breast cancer treated with mastectomy who have now returned to a screening population will still be included in the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (32)
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095, United States
University of California Davis Cancer Center
Sacramento, California, 95817, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Aurora, Colorado, 80010, United States
Washington Radiology Associates, P.C.
Washington D.C., District of Columbia, 20037, United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497, United States
Emory Health Care Clinic
Atlanta, Georgia, 30322, United States
Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago, Illinois, 60610, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637, United States
La Grange Memorial Hospital
La Grange, Illinois, 60525, United States
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1002, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21287, United States
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Lahey Clinic - Burlington
Burlington, Massachusetts, 01805, United States
William Beaumont Hospital
Royal Oak, Michigan, 48073, United States
Siteman Cancer Center
St Louis, Missouri, 63110, United States
Monmouth Medical Center
Long Branch, New Jersey, 07740-6395, United States
Shore Memorial Hospital
Somers Point, New Jersey, 08244, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10003, United States
Mount Sinai School of Medicine
New York, New York, 10029-6574, United States
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, 10032, United States
Elizabeth Wende Breast Clinic
Rochester, New York, 14620, United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267-0772, United States
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104-4283, United States
Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212-4772, United States
Roger Williams Medical Center/BUSM
Providence, Rhode Island, 02908-4735, United States
Simmons Cancer Center - Dallas
Dallas, Texas, 75390-8585, United States
Cancer Center at the University of Virginia
Charlottesville, Virginia, 22908, United States
University of Washington Medical Center
Seattle, Washington, 98112, United States
Sunnybrook and Women's College Health Sciences Centre
North York, Ontario, M4N 3M5, Canada
Related Publications (9)
Hendrick RE, Pisano ED, Averbukh A, Moran C, Berns EA, Yaffe MJ, Herman B, Acharyya S, Gatsonis C. Comparison of acquisition parameters and breast dose in digital mammography and screen-film mammography in the American College of Radiology Imaging Network digital mammographic imaging screening trial. AJR Am J Roentgenol. 2010 Feb;194(2):362-9. doi: 10.2214/AJR.08.2114.
PMID: 20093597BACKGROUNDTosteson AN, Stout NK, Fryback DG, Acharyya S, Herman BA, Hannah LG, Pisano ED; DMIST Investigators. Cost-effectiveness of digital mammography breast cancer screening. Ann Intern Med. 2008 Jan 1;148(1):1-10. doi: 10.7326/0003-4819-148-1-200801010-00002.
PMID: 18166758BACKGROUNDBaum JK, Hanna LG, Acharyya S, Mahoney MC, Conant EF, Bassett LW, Pisano ED. Use of BI-RADS 3-probably benign category in the American College of Radiology Imaging Network Digital Mammographic Imaging Screening Trial. Radiology. 2011 Jul;260(1):61-7. doi: 10.1148/radiol.11101285. Epub 2011 Apr 18.
PMID: 21502382RESULTHendrick RE, Cole EB, Pisano ED, Acharyya S, Marques H, Cohen MA, Jong RA, Mawdsley GE, Kanal KM, D'Orsi CJ, Rebner M, Gatsonis C. Accuracy of soft-copy digital mammography versus that of screen-film mammography according to digital manufacturer: ACRIN DMIST retrospective multireader study. Radiology. 2008 Apr;247(1):38-48. doi: 10.1148/radiol.2471070418.
PMID: 18372463RESULTPisano ED, Hendrick RE, Yaffe MJ, Baum JK, Acharyya S, Cormack JB, Hanna LA, Conant EF, Fajardo LL, Bassett LW, D'Orsi CJ, Jong RA, Rebner M, Tosteson AN, Gatsonis CA; DMIST Investigators Group. Diagnostic accuracy of digital versus film mammography: exploratory analysis of selected population subgroups in DMIST. Radiology. 2008 Feb;246(2):376-83. doi: 10.1148/radiol.2461070200.
PMID: 18227537RESULTBloomquist AK, Yaffe MJ, Pisano ED, Hendrick RE, Mawdsley GE, Bright S, Shen SZ, Mahesh M, Nickoloff EL, Fleischman RC, Williams MB, Maidment AD, Beideck DJ, Och J, Seibert JA. Quality control for digital mammography in the ACRIN DMIST trial: part I. Med Phys. 2006 Mar;33(3):719-36. doi: 10.1118/1.2163407.
PMID: 16878575RESULTYaffe MJ, Bloomquist AK, Mawdsley GE, Pisano ED, Hendrick RE, Fajardo LL, Boone JM, Kanal K, Mahesh M, Fleischman RC, Och J, Williams MB, Beideck DJ, Maidment AD. Quality control for digital mammography: part II. Recommendations from the ACRIN DMIST trial. Med Phys. 2006 Mar;33(3):737-52. doi: 10.1118/1.2164067.
PMID: 16878576RESULTPisano ED, Gatsonis CA, Yaffe MJ, Hendrick RE, Tosteson AN, Fryback DG, Bassett LW, Baum JK, Conant EF, Jong RA, Rebner M, D'Orsi CJ. American College of Radiology Imaging Network digital mammographic imaging screening trial: objectives and methodology. Radiology. 2005 Aug;236(2):404-12. doi: 10.1148/radiol.2362050440. Epub 2005 Jun 16.
PMID: 15961755RESULTPisano ED, Gatsonis C, Hendrick E, Yaffe M, Baum JK, Acharyya S, Conant EF, Fajardo LL, Bassett L, D'Orsi C, Jong R, Rebner M; Digital Mammographic Imaging Screening Trial (DMIST) Investigators Group. Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med. 2005 Oct 27;353(17):1773-83. doi: 10.1056/NEJMoa052911. Epub 2005 Sep 16.
PMID: 16169887RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Etta Pisano, MD
UNC Lineberger Comprehensive Cancer Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 6, 2001
First Posted
January 27, 2003
Study Start
October 1, 2001
Primary Completion
February 1, 2005
Study Completion
June 30, 2005
Last Updated
July 11, 2017
Record last verified: 2017-07