NCT00006311

Brief Summary

To examine the role of reduced vagal control of heart rate in the increased risk of cardiac mortality associated with anxiety in a population with established coronary artery disease (CAD). A second objective is to determine whether the effects of anxiety are independent of the effects of depression.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jun 1999

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 1999

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

September 28, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 29, 2000

Completed
3.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2004

Completed
Last Updated

February 18, 2016

Status Verified

January 1, 2006

First QC Date

September 28, 2000

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesCoronary DiseaseDepressionHeart DiseasesDeath, Sudden, CardiacArrhythmia

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (2)

  • Watkins LL, Blumenthal JA, Carney RM. Association of anxiety with reduced baroreflex cardiac control in patients after acute myocardial infarction. Am Heart J. 2002 Mar;143(3):460-6. doi: 10.1067/mhj.2002.120404.

    PMID: 11868052BACKGROUND

  • Hughes JW, Tomlinson A, Blumenthal JA, Davidson J, Sketch MH, Watkins LL. Social support and religiosity as coping strategies for anxiety in hospitalized cardiac patients. Ann Behav Med. 2004 Dec;28(3):179-85. doi: 10.1207/s15324796abm2803_6.

    PMID: 15576256BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary DiseaseDepressionHeart DiseasesDeath, Sudden, CardiacArrhythmias, Cardiac

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular DiseasesBehavioral SymptomsBehaviorHeart ArrestDeath, SuddenDeathPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Lana Watkins

    Duke University

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

September 28, 2000

First Posted

September 29, 2000

Study Start

June 1, 1999

Study Completion

May 1, 2004

Last Updated

February 18, 2016

Record last verified: 2006-01