Studies of HIV-1 Infection in Newly Infected Individuals in Southern Africa

NCT00006298 | Completed

• 1 other identifier: HIVNET 028
• Study Type: observational
• Target: 125
• Locations: 1 country
• Sites: 1

Brief Summary

The main goal of this study is to find out how the immune system responds to a specific type of HIV infection, known as C HIV-1, in order to develop a vaccine against this type of infection. The study involves Southern African populations. The HIV-1 virus changes rapidly and many different subtypes have been found. In South Africa, limited data have suggested Subtype C HIV-1 is the most common. This study strives to verify the most common subtype and also look at genetic differences and immune responses among newly infected individuals. Results will aid in the development of vaccines specific for certain geographical areas.

Conditions

HIV Infections; HIV Seronegativity

Keywords

HIV Antibodies; HIV-1; CD4 Lymphocyte Count; T-Lymphocytes, Cytotoxic; Genotype; Species Specificity; Neutralization Tests; Viral Load; Alleles; HLA Antigens; Cross Reactions; Immunodominant Epitopes; Haplotypes

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants may be eligible for this study if they:
• Are first HIV-negative and later test HIV-positive; or are HIV-positive and have evidence of being HIV-negative within the 8 months prior to first testing HIV-positive; or are HIV-positive with one test and HIV-negative with another test.

You may not qualify if:

• Participants will not be eligible for this study if they:
• Have a mental disorder that interferes with agreeing to do the study or with participating in the study.
• Are receiving anti-HIV treatment for more than 4 weeks.
• Have tuberculosis.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

Missie Allen

Research Triangle Park, North Carolina, 27709, United States

Location

Related Publications (2)

• Masemola A, Mashishi T, Khoury G, Mohube P, Mokgotho P, Vardas E, Colvin M, Zijenah L, Katzenstein D, Musonda R, Allen S, Kumwenda N, Taha T, Gray G, McIntyre J, Karim SA, Sheppard HW, Gray CM; HIVNET 028 Study Team. Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load. J Virol. 2004 Apr;78(7):3233-43. doi: 10.1128/jvi.78.7.3233-3243.2004.

  PMID: 15016844 RESULT

• Masemola AM, Mashishi TN, Khoury G, Bredell H, Paximadis M, Mathebula T, Barkhan D, Puren A, Vardas E, Colvin M, Zijenah L, Katzenstein D, Musonda R, Allen S, Kumwenda N, Taha T, Gray G, McIntyre J, Karim SA, Sheppard HW, Gray CM; HIVNET 028 Study Team. Novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype C HIV type 1 infection from southern Africa. J Immunol. 2004 Oct 1;173(7):4607-17. doi: 10.4049/jimmunol.173.7.4607.

  PMID: 15383595 RESULT

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases

Study Officials

• Haynes Sheppard

  STUDY CHAIR

• Desmond Martin

  STUDY CHAIR

• Clive Gray

  STUDY CHAIR

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: September 26, 2000
• First Posted: August 31, 2001
• Last Updated: September 25, 2008

Record last verified: 2004-07

Locations

US (1)