The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

NCT00006196 | Completed Phase 1

• 2 other identifiers: NCRR-M01RR00036-0754M01RR000036
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. An unknown number of elderly have vitamin D resistance resulting in a functional vitamin D deficiency state. Because there are no simple procedures or blood tests that identify vitamin D resistance, its prevalence and contribution to disability in the elderly is unknown. Our inability to screen for this condition precludes our ability to initiate and monitor treatment. Previous studies indicate that fingernail thickness correlates with vitamin D status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin D deficiency but also, those with vitamin D resistance. This procedure may also provide a way to monitor an individual's response to treatment. This study is designed to demonstrate the association between fingernail thickness and vitamin D status.

Conditions

Osteoporosis

Keywords

Vitamin D resistance

Interventions

Vitamin D DRUG

Eligibility Criteria

• Age: 25 Years - 75 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• females 25-75 years of age with no known bone disorders

You may not qualify if:

• history of vertebral fractures or nonvertebral fractures without trauma
• prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen)
• history of malignancy other than basal cell or squamous cell cancer of the skin
• use of steroids or anticonvulsants in the 6 months prior to enrollment

Sponsors & Collaborators

• National Center for Research Resources (NCRR): lead

Study Sites (1)

4488 Forest Park, Suite 201

St Louis, Missouri, 63108, United States

Location

MeSH Terms

Conditions

Osteoporosis

Interventions

Vitamin D

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Secosteroids; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: DIAGNOSTIC
• Sponsor Type: NIH

Study Record Dates

• First Submitted: September 7, 2000
• First Posted: September 8, 2000
• Last Updated: June 24, 2005

Record last verified: 2003-12

Locations

US (1)