CP-609,754 in Treating Patients With Advanced Solid Tumors

NCT00006085 | Unknown Phase 1

• 4 other identifiers: CDR0000068077MCC-12222PFIZER-A3321001NCI-G00-1824
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of CP-609,754 in treating patients who have advanced solid tumors.

Conditions

Unspecified Adult Solid Tumor, Protocol Specific

Keywords

unspecified adult solid tumor, protocol specific

Interventions

CP-609,754 DRUG

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed advanced solid tumor No standard curative therapy exists OR Refractory OR Disease progression while on therapy Measurable disease No brain metastases or leptomeningeal disease PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At least 12 weeks Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 mg/dL AST and ALT no greater than 2.5 times upper limit of normal (ULN) (no greater than 5 times ULN if liver metastases) Renal: Creatinine no greater than 1.5 times ULN OR Creatinine clearance at least 60 mL/min Cardiovascular: No prior hemorrhagic or thrombotic cerebrovascular events including transient ischemic attacks No clinically significant or unstable cardiac disease No myocardial infarction within past 6 months No serious cardiac arrhythmia or conduction abnormality Pulmonary: No chronic obstructive pulmonary disease requiring hospitalization within past year Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective barrier contraception Female patients must use barrier contraception plus a second form of effective contraception for at least 3 months prior to and during study No other serious concurrent systemic disorders that would preclude study No uncontrolled diabetes mellitus, thyroid disease, or seizure disorder No active neurologic or psychiatric disease No clinically apparent uncontrolled infection (e.g., HIV, hepatitis B or C) No known sensitivity to imidazole containing drugs (e.g., clotrimazole, oxiconazole, sulconazole, econazole, etoconazole, metronidazole, or ketoconazole) No clinically significant gastrointestinal abnormalities requiring intravenous alimentation No malabsorption syndrome or active peptic ulcer No other lab abnormalities (i.e., electrolytes, uric acid, calcium, phosphorous, or glucose) that would preclude study No other malignancy in past 5 years except nonmelanomatous skin cancer or carcinoma in situ of the breast or cervix PRIOR CONCURRENT THERAPY: Biologic therapy: At least 4 weeks since prior immunotherapy and recovered No prior bone marrow transplantation Chemotherapy: At least 4 weeks since prior chemotherapy (6 weeks for carboplatin, nitrosoureas, or mitomycin) and recovered Endocrine therapy: At least 1 week since prior hormonal therapy and recovered Concurrent hormone replacement therapy allowed No concurrent chronic steroid therapy Radiotherapy: At least 4 weeks since prior radiotherapy and recovered No prior radiotherapy to study lesions or to more than 30% of bone marrow containing areas Surgery: Not specified Other: At least 4 weeks since other prior investigational drugs No other concurrent investigational drugs Any regimens for other concurrent diseases or medical conditions must be stable for at least 4 weeks

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• H. Lee Moffitt Cancer Center and Research Institute: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612-9497, United States

Location

MeSH Terms

Interventions

CP 609754

Study Officials

• Daniel M. Sullivan, MD

  H. Lee Moffitt Cancer Center and Research Institute

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 1
• Purpose: TREATMENT
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 3, 2000
• First Posted: March 16, 2004
• Study Start: June 1, 2000
• Last Updated: December 19, 2013

Record last verified: 2001-12

Locations

US (1)