Endocrine Studies in Health and Disease

NCT00006073 | Terminated

• 2 other identifiers: 00018000-CH-0180
• Study Type: observational
• Target: 3,090
• Locations: 1 country
• Sites: 1

Brief Summary

This study will evaluate healthy normal volunteers and patients with a variety of endocrine disorders to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) train physicians in endocrinology. Patients with endocrine-related conditions and healthy volunteers of all ages may be eligible for this study. All participants will have a physical examination medical and history. They may be required to provide blood, saliva or urine samples and undergo ultrasound (using sound waves) or magnetic resonance (using a magnetic field) imaging to visualize internal body structures. Some healthy adult volunteers will have hormone-stimulating tests to assess endocrine function. These tests measure blood hormone levels before and after injection of a synthetic form of a hormone. A device called a heparin lock, through which the hormone is injected and the blood samples are collected, is placed in a vein in the arm or hand. Blood samples are drawn before the hormone is injected and at various intervals after the injection to measure levels of the hormone. These tests, which last from 1 to 3 hours, may include the following:

1. 1.CRH stimulation test corticotropin-releasing hormone is given to test pituitary and adrenal gland function
2. 2.ACTH stimulation test adrenocorticotrophic hormone is given to test adrenal gland function
3. 3.LHRH stimulation test luteinizing hormone-releasing hormone is given to test pituitary gland function
4. 4.TRH stimulation test thyroid-releasing hormone is given to test pituitary and thyroid gland function
5. 5.GHRH stimulation test growth hormone releasing hormone is given to measure growth hormone levels.

Conditions

Endocrine Diseases

Keywords

Evaluation; Endocrinology; Hormones; Metabolism; Teaching; Endocrine Disorder

Eligibility Criteria

• Age: Up to 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects and patients with endocrine-related conditions of all ages are eligible for this protocol. The actual selection of patients most appropriate for clinical training needs will be made by protocol investigators.
• Subjects with disabilities are not formally excluded from the study unless the disability would specifically prevent their participation. If a subject with cognitive impairment wishes to participate, there must be available a family member or other qualified individual holding a durable power of attorney who is able to guide the impaired subject s participation and be an advocate for their interests. This participation is limited to the non-research, clinical training arm of the study.

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

• Han JC, Reyes-Capo DP, Liu CY, Reynolds JC, Turkbey E, Turkbey IB, Bryant J, Marshall JD, Naggert JK, Gahl WA, Yanovski JA, Gunay-Aygun M. Comprehensive Endocrine-Metabolic Evaluation of Patients With Alstrom Syndrome Compared With BMI-Matched Controls. J Clin Endocrinol Metab. 2018 Jul 1;103(7):2707-2719. doi: 10.1210/jc.2018-00496.

  PMID: 29718281 DERIVED

MeSH Terms

Conditions

Endocrine System Diseases

Study Officials

• Margaret F Keil, C.R.N.P.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: OTHER
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 25, 2000
• First Posted: July 14, 2003
• Study Start: July 19, 2000
• Study Completion: August 31, 2016
• Last Updated: October 6, 2017

Record last verified: 2016-08-31

Locations

US (1)