NCT00005891

Brief Summary

OBJECTIVES: I. Determine the effectiveness of moderate dose cyclophosphamide and total lymphoid radiotherapy in terms of improving the survival and reducing the morbidity following allogeneic bone marrow transplantation in patients with Fanconi's aplastic anemia.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2000

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

June 2, 2000

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 5, 2000

Completed
Last Updated

June 24, 2005

Status Verified

July 1, 2004

First QC Date

June 2, 2000

Last Update Submit

June 23, 2005

Conditions

Fanconi's Anemia

Keywords

Fanconi's Anemiaaplastic anemiahematologic disordersrare disease

Interventions

cyclophosphamideDRUG
Allogeneic Bone Marrow TransplantationPROCEDURE

Eligibility Criteria

Age0 Years - 54 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
* Diagnosis of severe aplastic anemia with the typical phenotype of Fanconi's anemia: Short stature Hypoplastic radii Skin pigmentation Renal anomalies Chromosomal fragility * Family history of Fanconi's anemia * Histocompatible related donor No evidence of excessive in vitro chromosome fragility typical of Fanconi's anemia Normal CBC and bone marrow

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Fairview University Medical Center

Minneapolis, Minnesota, 55455, United States

Location

MeSH Terms

Conditions

Fanconi AnemiaAnemia, AplasticHematologic DiseasesRare Diseases

Interventions

Cyclophosphamide

Condition Hierarchy (Ancestors)

Anemia, Hypoplastic, CongenitalAnemiaHemic and Lymphatic DiseasesCongenital Bone Marrow Failure SyndromesBone Marrow Failure DisordersBone Marrow DiseasesGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesDNA Repair-Deficiency DisordersMetabolic DiseasesNutritional and Metabolic DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Phosphoramide MustardsNitrogen Mustard CompoundsMustard CompoundsHydrocarbons, HalogenatedHydrocarbonsOrganic ChemicalsPhosphoramidesOrganophosphorus Compounds

Study Officials

  • Daniel J. Weisdorf

    Fairview University Medical Center

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Purpose
TREATMENT
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 2, 2000

First Posted

June 5, 2000

Study Start

March 1, 2000

Last Updated

June 24, 2005

Record last verified: 2004-07

Locations

US(1)