NCT00005862

Brief Summary

Phase II trial to study the effectiveness of SU5416 in treating patients who have advanced, metastatic, or recurrent soft tissue sarcomas. SU5416 may stop the growth of soft tissue sarcomas by stopping blood flow to the tumor.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P50-P75 for phase_2

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 2, 2000

Completed
4 months until next milestone

Study Start

First participant enrolled

October 1, 2000

Completed
3.4 years until next milestone

First Posted

Study publicly available on registry

February 12, 2004

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2004

Completed
Last Updated

February 11, 2013

Status Verified

April 1, 2002

Enrollment Period

3.8 years

First QC Date

June 2, 2000

Last Update Submit

February 8, 2013

Conditions

Gastrointestinal Stromal TumorSarcoma

Keywords

stage III adult soft tissue sarcomarecurrent adult soft tissue sarcomagastrointestinal stromal tumorstage IV adult soft tissue sarcoma

Study Arms (1)

Arm I

EXPERIMENTAL

atients receive SU5416 IV twice weekly for 4 weeks. Treatment continues every 4 weeks in the absence of disease progression or unacceptable toxicity.

Drug: semaxanib

Interventions

semaxanibDRUG
Arm I

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS: * Histologically confirmed advanced, metastatic, recurrent, or unresectable soft tissue sarcoma or gastrointestinal stromal tumor * Measurable disease defined as lesions that can be measured in at least one dimension as at least 20 mm with conventional techniques or at least 10 mm with spiral CT scan * Must have received prior chemotherapy with no response or progression after initial response * Evidence of disease progression in past 3 months * No CNS metastases or primary brain tumors PATIENT CHARACTERISTICS: * Age: 18 and over * Performance status: ECOG 0-1 * Life expectancy: At least 12 weeks * WBC greater than 2,000/mm3 * Platelet count greater than 100,000/mm3 * Fibrin split products no greater than 0.001 mg * Fibrinogen greater than 200 mg/dL * Bilirubin no greater than upper limit of normal (ULN) * AST/ALT less than 1.5 times ULN * PT/PTT less than 1.25 times ULN * Creatinine no greater than 1.5 mg/dL * At least 1 year since bypass surgery for atherosclerotic coronary artery disease * No uncompensated coronary artery disease * No history of myocardial infarction or unstable/severe angina in past 6 months * No severe peripheral vascular disease * No history of deep venous or arterial thrombosis in past 3 months * No history of pulmonary embolism in past 3 months * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No diabetes mellitus * No history of bleeding diathesis * No known active retroviral disease * No AIDS-associated Kaposi's sarcoma * No history of allergic reaction to Cremophor or paclitaxel * No uncontrolled illness or psychiatric disorder that would preclude study PRIOR CONCURRENT THERAPY: * No concurrent immunotherapy * At least 3 weeks since prior chemotherapy (6 weeks since mitomycin or nitrosoureas) * No concurrent chemotherapy * At least 3 weeks since prior radiotherapy * No concurrent radiotherapy * Greater than 2 weeks since prior minor surgery (greater than 4 weeks since major surgery) * No concurrent antiinflammatory drugs

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (2)

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

Gastrointestinal Stromal TumorsSarcoma

Interventions

Semaxinib

Condition Hierarchy (Ancestors)

Neoplasms, Connective TissueNeoplasms, Connective and Soft TissueNeoplasms by Histologic TypeNeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsDigestive System DiseasesGastrointestinal Diseases

Study Officials

  • George D. Demetri, MD

    Dana-Farber Cancer Institute

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 2, 2000

First Posted

February 12, 2004

Study Start

October 1, 2000

Primary Completion

July 1, 2004

Last Updated

February 11, 2013

Record last verified: 2002-04

Locations

US(2)