Radiation Therapy After Surgery in Treating Women With Early Stage Breast Cancer
Standardization of Breast Radiotherapy: Trial B - A Randomized Comparison of Fractionation Regimens After Local Excision or Mastectomy in Women With Early Stage Breast Cancer
3 other identifiers
interventional
N/A
1 country
32
Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective following surgery for breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two regimens of radiation therapy following surgery in treating women who have early stage breast cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jan 1999
32 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 1999
CompletedFirst Submitted
Initial submission to the registry
May 2, 2000
CompletedFirst Posted
Study publicly available on registry
May 19, 2003
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2004
CompletedDecember 19, 2013
July 1, 2001
May 2, 2000
December 18, 2013
Conditions
Keywords
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (32)
Royal Sussex County Hospital
Brighton, England, BN2 5BE, United Kingdom
Addenbrooke's NHS Trust
Cambridge, England, CB2 2QQ, United Kingdom
Cheltenham General Hospital
Cheltenham, England, GL53 7AN, United Kingdom
Royal Devon and Exeter Hospital
Exeter, England, EX2 5DW, United Kingdom
Royal Surrey County Hospital
Guildford, England, GU2 5XX, United Kingdom
Ipswich Hospital NHS Trust
Ipswich, England, IP4 5PD, United Kingdom
University Hospitals of Leicester
Leicester, England, LE1 5WW, United Kingdom
Guy's and St. Thomas' Hospitals Trust
London, England, SE1 9RT, United Kingdom
Maidstone Hospital
Maidstone, England, ME16 9QQ, United Kingdom
Christie Hospital N.H.S. Trust
Manchester, England, M20 4BX, United Kingdom
Clatterbridge Centre for Oncology NHS Trust
Merseyside, England, L63 4JY, United Kingdom
South Tees Hospitals NHS Trust
Middlesbrough, Cleveland, England, TS4 3BW, United Kingdom
King Edward VII Hospital
Midhurst, England, GU29 OBL, United Kingdom
Mount Vernon Hospital
Northwood, England, HA6 2RN, United Kingdom
Norfolk & Norwich Hospital
Norwich, England, NR1 3SR, United Kingdom
Nottingham City Hospital NHS Trust
Nottingham, England, NG5 1PB, United Kingdom
Derriford Hospital
Plymouth, England, PL6 8DH, United Kingdom
Royal Berkshire Hospital
Reading, England, RG1 5AN, United Kingdom
Oldchurch Hospital
Romford, England, RM7 OBE, United Kingdom
Weston Park Hospital
Sheffield, England, S1O 2SJ, United Kingdom
Royal Shrewsbury Hospital
Shrewsbury, England, United Kingdom
North Staffs Royal Infirmary
Stoke-on-Trent, England, ST4 7LN, United Kingdom
Royal Marsden Hospital
Sutton, England, SM2 5PT, United Kingdom
Torbay Hospital
Torquay Devon, England, TQ2 7AA, United Kingdom
Southend NHS Trust Hospital
Westcliff-on-Sea, England, United Kingdom
New Cross Hospital
Wolverhampton, England, WV10 0QP, United Kingdom
Belfast City Hospital Trust Incorporating Belvoir Park Hospital
Belfast, Northern Ireland, BT8 8JR, United Kingdom
Ninewells Hospital and Medical School
Dundee, Scotland, DD1 9SY, United Kingdom
Velindre Hospital
Cardiff, Wales, CF4 7XL, United Kingdom
Cumberland Infirmary
Carlisle, CA2 7HY, United Kingdom
Saint Mary's Hospital
Portsmouth Hants, PO3 6AD, United Kingdom
Royal Preston Hospital
Preston, PR2 9HT, United Kingdom
Related Publications (4)
Hopwood P, Haviland JS, Sumo G, Mills J, Bliss JM, Yarnold JR; START Trial Management Group. Comparison of patient-reported breast, arm, and shoulder symptoms and body image after radiotherapy for early breast cancer: 5-year follow-up in the randomised Standardisation of Breast Radiotherapy (START) trials. Lancet Oncol. 2010 Mar;11(3):231-40. doi: 10.1016/S1470-2045(09)70382-1. Epub 2010 Feb 6.
PMID: 20138809RESULTSTART Trialists' Group; Bentzen SM, Agrawal RK, Aird EG, Barrett JM, Barrett-Lee PJ, Bentzen SM, Bliss JM, Brown J, Dewar JA, Dobbs HJ, Haviland JS, Hoskin PJ, Hopwood P, Lawton PA, Magee BJ, Mills J, Morgan DA, Owen JR, Simmons S, Sumo G, Sydenham MA, Venables K, Yarnold JR. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet. 2008 Mar 29;371(9618):1098-107. doi: 10.1016/S0140-6736(08)60348-7. Epub 2008 Mar 19.
PMID: 18355913RESULTHopwood P, Haviland J, Mills J, Sumo G, M Bliss J; START Trial Management Group. The impact of age and clinical factors on quality of life in early breast cancer: an analysis of 2208 women recruited to the UK START Trial (Standardisation of Breast Radiotherapy Trial). Breast. 2007 Jun;16(3):241-51. doi: 10.1016/j.breast.2006.11.003. Epub 2007 Jan 19.
PMID: 17236771RESULTVenables K, Miles EA, Aird EG, Hoskin PJ; START Trial Management Group. The use of in vivo thermoluminescent dosimeters in the quality assurance programme for the START breast fractionation trial. Radiother Oncol. 2004 Jun;71(3):303-10. doi: 10.1016/j.radonc.2004.02.008.
PMID: 15172146RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
John R. Yarnold, MD, FRCR
Royal Marsden NHS Foundation Trust
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
May 2, 2000
First Posted
May 19, 2003
Study Start
January 1, 1999
Study Completion
June 1, 2004
Last Updated
December 19, 2013
Record last verified: 2001-07