NCT00005539

Brief Summary

To investigate the prevalence and incidence rates of cardiovascular disease morbidity and mortality in people with Type 1 diabetes of long duration.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Feb 1999

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 1999

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2003

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2003

Completed
Last Updated

February 8, 2016

Status Verified

February 1, 2016

Enrollment Period

3.9 years

First QC Date

May 25, 2000

Last Update Submit

February 5, 2016

Conditions

Cardiovascular DiseasesDiabetes MellitusHeart DiseasesDiabetes Mellitus, Insulin-dependent

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (18)

  • Klein R, Klein BE, Moss SE, Cruickshanks KJ. Association of ocular disease and mortality in a diabetic population. Arch Ophthalmol. 1999 Nov;117(11):1487-95. doi: 10.1001/archopht.117.11.1487.

    PMID: 10565517BACKGROUND

  • Valmadrid CT, Klein R, Moss SE, Klein BE, Cruickshanks KJ. Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus. JAMA. 1999 Jul 21;282(3):239-46. doi: 10.1001/jama.282.3.239.

    PMID: 10422992BACKGROUND

  • Wong TY, Cruickshank KJ, Klein R, Klein BE, Moss SE, Palta M, Riley WJ, Maclaren NK, Vadheim CM, Rotter JI. HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy. Ophthalmology. 2002 Feb;109(2):275-81. doi: 10.1016/s0161-6420(01)00925-3.

    PMID: 11825808BACKGROUND

  • Wong TY, Klein R, Klein BE, Tielsch JM, Hubbard L, Nieto FJ. Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. Surv Ophthalmol. 2001 Jul-Aug;46(1):59-80. doi: 10.1016/s0039-6257(01)00234-x.

    PMID: 11525792BACKGROUND

  • Wong TY, Klein R. Retinal arteriolar emboli: epidemiology and risk of stroke. Curr Opin Ophthalmol. 2002 Jun;13(3):142-6. doi: 10.1097/00055735-200206000-00002.

    PMID: 12011681BACKGROUND

  • Klein R. Prevention of visual loss from diabetic retinopathy. Surv Ophthalmol. 2002 Dec;47 Suppl 2:S246-52. doi: 10.1016/s0039-6257(02)00388-0.

    PMID: 12507626BACKGROUND

  • Klein R, Klein BE, Moss SE, Wong TY, Hubbard L, Cruickshanks KJ, Palta M. The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol. 2004 Jan;122(1):76-83. doi: 10.1001/archopht.122.1.76.

    PMID: 14718299BACKGROUND

  • Wang JJ, Mitchell P, Rochtchina E, Tan AG, Wong TY, Klein R. Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study. Br J Ophthalmol. 2004 Jan;88(1):104-9. doi: 10.1136/bjo.88.1.104.

    PMID: 14693785BACKGROUND

  • Wong TY, Shankar A, Klein R, Klein BE. Retinal vessel diameters and the incidence of gross proteinuria and renal insufficiency in people with type 1 diabetes. Diabetes. 2004 Jan;53(1):179-84. doi: 10.2337/diabetes.53.1.179.

    PMID: 14693713BACKGROUND

  • Wang JJ, Mitchell P, Leung H, Rochtchina E, Wong TY, Klein R. Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension. 2003 Oct;42(4):534-41. doi: 10.1161/01.HYP.0000090122.38230.41. Epub 2003 Aug 25.

    PMID: 12939235BACKGROUND

  • Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Hubbard LD, Klein R, Mitchell P. Computer-assisted retinal vessel measurement in an older population: correlation between right and left eyes. Clin Exp Ophthalmol. 2003 Aug;31(4):326-30. doi: 10.1046/j.1442-9071.2003.00661.x.

    PMID: 12880458BACKGROUND

  • Tan AG, Wang JJ, Rochtchina E, Klein R, Wong TY, Hubbard LD, Mitchell P. Correlation between generalized and focal retinal arteriolar narrowing in an older population. Clin Exp Ophthalmol. 2003 Aug;31(4):322-5. doi: 10.1046/j.1442-9071.2003.00662.x.

    PMID: 12880457BACKGROUND

  • Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Klein R, Hubbard LD, Mitchell P. Relationships between age, blood pressure, and retinal vessel diameters in an older population. Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2900-4. doi: 10.1167/iovs.02-1114.

    PMID: 12824229BACKGROUND

  • Klein R. Is intensive management of blood pressure to prevent visual loss in persons with type 2 diabetes indicated? Arch Ophthalmol. 2004 Nov;122(11):1707-9. doi: 10.1001/archopht.122.11.1707. No abstract available.

    PMID: 15534135BACKGROUND

  • Klein BE, Klein R, Hall ER, Lee KE, Jensen K. The comparability of estimates of retroilluminated lens opacities as judged from film-based and digital imaging. Am J Ophthalmol. 2004 Oct;138(4):668-70. doi: 10.1016/j.ajo.2004.04.068.

    PMID: 15488807BACKGROUND

  • Klein BE, Klein R, McBride PE, Cruickshanks KJ, Palta M, Knudtson MD, Moss SE, Reinke JO. Cardiovascular disease, mortality, and retinal microvascular characteristics in type 1 diabetes: Wisconsin epidemiologic study of diabetic retinopathy. Arch Intern Med. 2004 Sep 27;164(17):1917-24. doi: 10.1001/archinte.164.17.1917.

    PMID: 15451768BACKGROUND

  • Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P. Impact of current and past blood pressure on retinal arteriolar diameter in an older population. J Hypertens. 2004 Aug;22(8):1543-9. doi: 10.1097/01.hjh.0000125455.28861.3f.

    PMID: 15257178BACKGROUND

  • Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P. Does hormone replacement therapy influence retinal microvascular caliber? Microvasc Res. 2004 Jan;67(1):48-54. doi: 10.1016/j.mvr.2003.10.002.

    PMID: 14709402BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesDiabetes MellitusHeart DiseasesDiabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Ronald Klein, MD, MPH

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

February 1, 1999

Primary Completion

January 1, 2003

Study Completion

January 1, 2003

Last Updated

February 8, 2016

Record last verified: 2016-02