Genetics of CVD Risk Factors in Samoans

NCT00005528 | Completed

• 2 other identifiers: 5060R01HL052611
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in Samoans residing in American and Western Samoa, who were exposed to the biobehavioral changes of modernization.

Conditions

Cardiovascular Diseases; Heart Diseases; Obesity; Atherosclerosis

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (10)

• Kamboh MI, McGarvey ST, Aston CE, Ferrell RE, Bausserman L. Plasma lipoprotein(a) distribution and its correlates among Samoans. Hum Biol. 2000 Apr;72(2):321-36.

  PMID: 10803663 BACKGROUND

• Newman JD, McGarvey ST, Steele MS. Longitudinal association of cardiovascular reactivity and blood pressure in Samoan adolescents. Psychosom Med. 1999 Mar-Apr;61(2):243-9. doi: 10.1097/00006842-199903000-00017.

  PMID: 10204978 BACKGROUND

• Galanis DJ, McGarvey ST, Quested C, Sio B, Afele-Fa'amuli SA. Dietary intake of modernizing Samoans: implications for risk of cardiovascular disease. J Am Diet Assoc. 1999 Feb;99(2):184-90. doi: 10.1016/s0002-8223(99)00044-9.

  PMID: 9972185 BACKGROUND

• Steele MS, McGarvey ST. Anger expression, age, and blood pressure in modernizing Samoan adults. Psychosom Med. 1997 Nov-Dec;59(6):632-7. doi: 10.1097/00006842-199711000-00013.

  PMID: 9407584 BACKGROUND

• Steele MS, McGarvey ST. Expression of anger by Samoan adults. Psychol Rep. 1996 Dec;79(3 Pt 2):1339-48. doi: 10.2466/pr0.1996.79.3f.1339.

  PMID: 9009791 BACKGROUND

• DePrince K, McGarvey ST, McAllister AE, Bausserman L, Aston CE, Ferrell RE, Kamboh MI. Genetic effect of two APOA repeat polymorphisms (kringle 4 and pentanucleotide repeats) on plasma Lp(a) levels in American Samoans. Hum Biol. 2001 Feb;73(1):91-104. doi: 10.1353/hub.2001.0006.

  PMID: 11332648 BACKGROUND

• Moffett S, Martinson J, Shriver MD, Deka R, McGarvey ST, Barrantes R, Ferrell RE. Genetic diversity and evolution of the human leptin locus tetranucleotide repeat. Hum Genet. 2002 May;110(5):412-7. doi: 10.1007/s00439-002-0715-5. Epub 2002 Apr 4.

  PMID: 12073010 BACKGROUND

• McGarvey ST, Forrest W, Weeks DE, Sun G, Smelser D, Tufa J, Viali S, Deka R. Human leptin locus (LEP) alleles and BMI in Samoans. Int J Obes Relat Metab Disord. 2002 Jun;26(6):783-8. doi: 10.1038/sj.ijo.0801996.

  PMID: 12037648 BACKGROUND

• Tsai HJ, Sun G, Weeks DE, Kaushal R, Wolujewicz M, McGarvey ST, Tufa J, Viali S, Deka R. Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. Am J Hum Genet. 2001 Dec;69(6):1236-44. doi: 10.1086/324646. Epub 2001 Nov 5.

  PMID: 11704924 BACKGROUND

• Choh AC, Gage TB, McGarvey ST, Comuzzie AG. Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans. Am J Phys Anthropol. 2001 Aug;115(4):304-11. doi: 10.1002/ajpa.1086.

  PMID: 11471128 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Obesity; Atherosclerosis

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Mohammad Kamboh

  University of Pittsburgh

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: April 1, 1995
• Study Completion: February 1, 2000
• Last Updated: May 13, 2016

Record last verified: 2004-08