NCT00005525

Brief Summary

To conduct a genetic analysis of anatomic risk factors for sleep apnea in a well-characterized United States population-based registry of elderly male twins who have been successfully followed for the past 30 years.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1998

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1998

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
2.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2002

Completed
Last Updated

March 16, 2016

Status Verified

March 1, 2005

First QC Date

May 25, 2000

Last Update Submit

March 15, 2016

Conditions

Lung DiseasesSleep Apnea SyndromesObesity

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (3)

  • Carmelli D, Bliwise DL, Swan GE, Reed T. A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry. J Sleep Res. 2001 Mar;10(1):53-8. doi: 10.1046/j.1365-2869.2001.00241.x.

    PMID: 11285055BACKGROUND

  • Carmelli D, Bliwise DL, Swan GE, Reed T. Genetic factors in self-reported snoring and excessive daytime sleepiness: a twin study. Am J Respir Crit Care Med. 2001 Sep 15;164(6):949-52. doi: 10.1164/ajrccm.164.6.2012001.

    PMID: 11587976BACKGROUND

  • Carmelli D, Colrain IM, Swan GE, Bliwise DL. Genetic and environmental influences in sleep-disordered breathing in older male twins. Sleep. 2004 Aug 1;27(5):917-22. doi: 10.1093/sleep/27.5.917.

    PMID: 15453550BACKGROUND

MeSH Terms

Conditions

Lung DiseasesSleep Apnea SyndromesObesity

Condition Hierarchy (Ancestors)

Respiratory Tract DiseasesApneaRespiration DisordersSleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesOverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Dorit Carmelli

    SRI International

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

August 1, 1998

Study Completion

July 1, 2002

Last Updated

March 16, 2016

Record last verified: 2005-03