NCT00005502

Brief Summary

To study the entire population of Olmsted County, Minnesota, including all age categories, to examine the secular trends in coronary heart disease (CHD) mortality, myocardial infarction (MI) incidence, and natural history, including MI severity, case fatality and post-MI morbidity. Also, to examine the time trends in the prevalence of CHD at post-mortem because of the uniquely high autopsy rate in Olmsted County.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5,476

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2002

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
2.4 years until next milestone

Study Start

First participant enrolled

October 1, 2002

Completed
10.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2013

Completed
Last Updated

May 14, 2013

Status Verified

May 1, 2013

Enrollment Period

10.5 years

First QC Date

May 25, 2000

Last Update Submit

May 13, 2013

Conditions

Cardiovascular DiseasesCoronary DiseaseMyocardial InfarctionHeart Diseases

Outcome Measures

Primary Outcomes (1)

  • To measure the number of Olmsted County,MN residents who have a Myocardial Infarction and Unstable Angina.

    1979 through 2012

Secondary Outcomes (1)

  • To measure the survival of Olmsted County, MN residents after having a Myocardial Infarction or Unstable Angina event

    1979-2012

Other Outcomes (1)

  • To examine the value of biomarkers on prediction of risks in Olmsted County, MN residents who have a Myocardial Infarction or Unstable Angina

    2002-2012

Study Arms (1)

Residents of Olmsted County, MN with elevated Troponins

Anyone admitted to St Marys or Rochester Methodist Hospitals who have an elevated troponin during their hospitalization and are residents of Olmsted County, MN

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All residents of Olmsted County, MN who are hospitalized and have an elevated Troponin level.Non-residenst of Olmsted County are excluded.

All residents of Olmsted County, MN who are hospitalized and have an elevated Troponin level.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (2)

St Marys Hospital

Rochester, Minnesota, 55902, United States

Location

Rochester Methodist Hospital

Rochester, Minnesota, 55905, United States

Location

Related Publications (27)

  • Roger VL, Farkouh ME, Weston SA, Reeder GS, Jacobsen SJ, Zinsmeister AR, Yawn BP, Kopecky SL, Gabriel SE. Sex differences in evaluation and outcome of unstable angina. JAMA. 2000 Feb 2;283(5):646-52. doi: 10.1001/jama.283.5.646.

    PMID: 10665705BACKGROUND

  • Roger VL, Jacobsen SJ, Weston SA, Bailey KR, Kottke TE, Frye RL. Trends in heart disease deaths in Olmsted County, Minnesota, 1979-1994. Mayo Clin Proc. 1999 Jul;74(7):651-7. doi: 10.4065/74.7.651.

    PMID: 10405692BACKGROUND

  • Roger VL, Weston SA, Killian JM, Pfeifer EA, Belau PG, Kottke TE, Frye RL, Bailey KR, Jacobsen SJ. Time trends in the prevalence of atherosclerosis: a population-based autopsy study. Am J Med. 2001 Mar;110(4):267-73. doi: 10.1016/s0002-9343(00)00709-9.

    PMID: 11239844BACKGROUND

  • Goraya TY, Jacobsen SJ, Belau PG, Weston SA, Kottke TE, Roger VL. Validation of death certificate diagnosis of out-of-hospital coronary heart disease deaths in Olmsted County, Minnesota. Mayo Clin Proc. 2000 Jul;75(7):681-7. doi: 10.4065/75.7.681.

    PMID: 10907382BACKGROUND

  • Targonski P, Jacobsen SJ, Weston SA, Leibson CL, Pfeifer E, Nemetz P, Roger VL. Referral to autopsy: effect of antemortem cardiovascular disease: a population-based study in Olmsted County, Minnesota. Ann Epidemiol. 2001 May;11(4):264-70. doi: 10.1016/s1047-2797(00)00220-9.

    PMID: 11306345BACKGROUND

  • Hellermann JP, Reeder GS, Jacobsen SJ, Weston SA, Killian JM, Roger VL. Longitudinal trends in the severity of acute myocardial infarction: a population study in Olmsted County, Minnesota. Am J Epidemiol. 2002 Aug 1;156(3):246-53. doi: 10.1093/aje/kwf034.

    PMID: 12142259BACKGROUND

  • Roger VL, Killian J, Henkel M, Weston SA, Goraya TY, Yawn BP, Kottke TE, Frye RL, Jacobsen SJ. Coronary disease surveillance in Olmsted County objectives and methodology. J Clin Epidemiol. 2002 Jun;55(6):593-601. doi: 10.1016/s0895-4356(02)00390-6.

    PMID: 12063101BACKGROUND

  • Roger VL, Jacobsen SJ, Weston SA, Goraya TY, Killian J, Reeder GS, Kottke TE, Yawn BP, Frye RL. Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994. Ann Intern Med. 2002 Mar 5;136(5):341-8. doi: 10.7326/0003-4819-136-5-200203050-00005.

    PMID: 11874305BACKGROUND

  • Goraya TY, Leibson CL, Palumbo PJ, Weston SA, Killian JM, Pfeifer EA, Jacobsen SJ, Frye RL, Roger VL. Coronary atherosclerosis in diabetes mellitus: a population-based autopsy study. J Am Coll Cardiol. 2002 Sep 4;40(5):946-53. doi: 10.1016/s0735-1097(02)02065-x.

    PMID: 12225721BACKGROUND

  • Goraya TY, Jacobsen SJ, Kottke TE, Frye RL, Weston SA, Roger VL. Coronary heart disease death and sudden cardiac death: a 20-year population-based study. Am J Epidemiol. 2003 May 1;157(9):763-70. doi: 10.1093/aje/kwg057.

    PMID: 12727669BACKGROUND

  • Hellermann JP, Goraya TY, Jacobsen SJ, Weston SA, Reeder GS, Gersh BJ, Redfield MM, Rodeheffer RJ, Yawn BP, Roger VL. Incidence of heart failure after myocardial infarction: is it changing over time? Am J Epidemiol. 2003 Jun 15;157(12):1101-7. doi: 10.1093/aje/kwg078.

    PMID: 12796046BACKGROUND

  • Hellermann JP, Jacobsen SJ, Reeder GS, Lopez-Jimenez F, Weston SA, Roger VL. Heart failure after myocardial infarction: prevalence of preserved left ventricular systolic function in the community. Am Heart J. 2003 Apr;145(4):742-8. doi: 10.1067/mhj.2003.187.

    PMID: 12679774BACKGROUND

  • Singh M, Reeder GS, Jacobsen SJ, Weston S, Killian J, Roger VL. Scores for post-myocardial infarction risk stratification in the community. Circulation. 2002 Oct 29;106(18):2309-14. doi: 10.1161/01.cir.0000036598.12888.de.

    PMID: 12403659BACKGROUND

  • Hellermann JP, Jacobsen SJ, Gersh BJ, Rodeheffer RJ, Reeder GS, Roger VL. Heart failure after myocardial infarction: a review. Am J Med. 2002 Sep;113(4):324-30. doi: 10.1016/s0002-9343(02)01185-3.

    PMID: 12361819BACKGROUND

  • Roger VL, Jacobsen SJ, Weston SA, Pellikka PA, Miller TD, Bailey KR, Gersh BJ. Sex differences in evaluation and outcome after stress testing. Mayo Clin Proc. 2002 Jul;77(7):638-45. doi: 10.4065/77.7.638.

    PMID: 12108601BACKGROUND

  • Jokhadar M, Jacobsen SJ, Reeder GS, Weston SA, Roger VL. Sudden death and recurrent ischemic events after myocardial infarction in the community. Am J Epidemiol. 2004 Jun 1;159(11):1040-6. doi: 10.1093/aje/kwh147.

    PMID: 15155288BACKGROUND

  • Lopez-Jimenez F, Jacobsen SJ, Reeder GS, Weston SA, Meverden RA, Roger VL. Prevalence and secular trends of excess body weight and impact on outcomes after myocardial infarction in the community. Chest. 2004 Apr;125(4):1205-12. doi: 10.1378/chest.125.4.1205.

    PMID: 15078726BACKGROUND

  • Lopez-Jimenez F, Goraya TY, Hellermann JP, Jacobsen SJ, Reeder GS, Weston SA, Roger VL. Measurement of ejection fraction after myocardial infarction in the population. Chest. 2004 Feb;125(2):397-403. doi: 10.1378/chest.125.2.397.

    PMID: 14769715BACKGROUND

  • Witt BJ, Jacobsen SJ, Weston SA, Killian JM, Meverden RA, Allison TG, Reeder GS, Roger VL. Cardiac rehabilitation after myocardial infarction in the community. J Am Coll Cardiol. 2004 Sep 1;44(5):988-96. doi: 10.1016/j.jacc.2004.05.062.

    PMID: 15337208BACKGROUND

  • Perschbacher JM, Reeder GS, Jacobsen SJ, Weston SA, Killian JM, Slobodova A, Roger VL. Evidence-based therapies for myocardial infarction: secular trends and determinants of practice in the community. Mayo Clin Proc. 2004 Aug;79(8):983-91. doi: 10.4065/79.8.983.

    PMID: 15301324BACKGROUND

  • Bursi F, Enriquez-Sarano M, Nkomo VT, Jacobsen SJ, Weston SA, Meverden RA, Roger VL. Heart failure and death after myocardial infarction in the community: the emerging role of mitral regurgitation. Circulation. 2005 Jan 25;111(3):295-301. doi: 10.1161/01.CIR.0000151097.30779.04. Epub 2005 Jan 17.

    PMID: 15655133BACKGROUND

  • Hellermann JP, Jacobsen SJ, Redfield MM, Reeder GS, Weston SA, Roger VL. Heart failure after myocardial infarction: clinical presentation and survival. Eur J Heart Fail. 2005 Jan;7(1):119-25. doi: 10.1016/j.ejheart.2004.04.011.

    PMID: 15642543BACKGROUND

  • Witt BJ, Brown RD Jr, Jacobsen SJ, Weston SA, Yawn BP, Roger VL. A community-based study of stroke incidence after myocardial infarction. Ann Intern Med. 2005 Dec 6;143(11):785-92. doi: 10.7326/0003-4819-143-11-200512060-00006.

    PMID: 16330789BACKGROUND

  • Leibson CL, Burke JP, Ransom JE, Forsgren J, Melton J 3rd, Bailey KR, Palumbo PJ. Relative risk of mortality associated with diabetes as a function of birth weight. Diabetes Care. 2005 Dec;28(12):2839-43. doi: 10.2337/diacare.28.12.2839.

    PMID: 16306542BACKGROUND

  • Miller TD, Roger VL, Hodge DO, Gibbons RJ. A simple clinical score accurately predicts outcome in a community-based population undergoing stress testing. Am J Med. 2005 Aug;118(8):866-72. doi: 10.1016/j.amjmed.2005.03.013.

    PMID: 16084179BACKGROUND

  • Tleyjeh IM, Steckelberg JM, Murad HS, Anavekar NS, Ghomrawi HM, Mirzoyev Z, Moustafa SE, Hoskin TL, Mandrekar JN, Wilson WR, Baddour LM. Temporal trends in infective endocarditis: a population-based study in Olmsted County, Minnesota. JAMA. 2005 Jun 22;293(24):3022-8. doi: 10.1001/jama.293.24.3022.

    PMID: 15972564BACKGROUND

  • Bursi F, Rocca WA, Killian JM, Weston SA, Knopman DS, Jacobsen SJ, Roger VL. Heart disease and dementia: a population-based study. Am J Epidemiol. 2006 Jan 15;163(2):135-41. doi: 10.1093/aje/kwj025. Epub 2005 Nov 17.

    PMID: 16293716BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

plasma, serum and white blood cells are stored for future research projects

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary DiseaseMyocardial InfarctionHeart Diseases

Condition Hierarchy (Ancestors)

Myocardial IschemiaVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Study Officials

  • Veronique Roger

    Mayo Foundation

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Consultant- Cardiology NonInvasive

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

October 1, 2002

Primary Completion

April 1, 2013

Study Completion

April 1, 2013

Last Updated

May 14, 2013

Record last verified: 2013-05

Locations

US(2)