NCT00005485

Brief Summary

This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American adults. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the University of Mississippi Medical Center), NIMHD, and NHLBI.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
5,306

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2000

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
4 months until next milestone

Study Start

First participant enrolled

September 19, 2000

Completed
24.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 12, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 12, 2025

Completed
Last Updated

July 9, 2025

Status Verified

June 1, 2025

Enrollment Period

24.9 years

First QC Date

May 25, 2000

Last Update Submit

July 3, 2025

Conditions

Cardiovascular DiseasesHeart DiseasesAtherosclerosisCoronary DiseaseHypertensionCerebrovascular Disorders

Keywords

Cardiovascular diseasesHeart failureStrokeCoronary heart diseaseDiabetesHypertensionChronic kidney disease

Outcome Measures

Primary Outcomes (1)

  • Cardiovascular Disease

    Coronary Heart Disease, Stroke, Heart Failure

    2000-2016

Secondary Outcomes (1)

  • Mortality

    2000-2018

Eligibility Criteria

Age35 Years - 84 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

African-American adult residents of metropolitan Jackson, Mississippi

You may qualify if:

  • African American
  • Residents of Jackson, Mississippi

You may not qualify if:

  • Institutionalization

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UMMC, JSU, Tougaloo College, MSDH

Jackson, Mississippi, 39213, United States

Location

Related Publications (11)

  • Sempos CT, Bild DE, Manolio TA. Overview of the Jackson Heart Study: a study of cardiovascular diseases in African American men and women. Am J Med Sci. 1999 Mar;317(3):142-6. doi: 10.1097/00000441-199903000-00002.

    PMID: 10100686BACKGROUND

  • Crook ED, Taylor H. Traditional and non-traditional risk factors for cardiovascular and renal disease in African Americans: a project of the Jackson Heart Study investigators. Am J Med Sci. 2002 Sep;324(3):115. doi: 10.1097/00000441-200209000-00001. No abstract available.

    PMID: 12240708BACKGROUND

  • Wyatt SB, Williams DR, Calvin R, Henderson FC, Walker ER, Winters K. Racism and cardiovascular disease in African Americans. Am J Med Sci. 2003 Jun;325(6):315-31. doi: 10.1097/00000441-200306000-00003.

    PMID: 12811228BACKGROUND

  • Crook ED, Taylor H. Traditional and nontraditional risk factors for cardiovascular and renal disease in African Americans (Part 2): a project of the Jackson Heart Study investigators. Am J Med Sci. 2003 Jun;325(6):305-6. doi: 10.1097/00000441-200306000-00001. No abstract available.

    PMID: 12811226BACKGROUND

  • Wyatt SB, Diekelmann N, Henderson F, Andrew ME, Billingsley G, Felder SH, Fuqua S, Jackson PB. A community-driven model of research participation: the Jackson Heart Study Participant Recruitment and Retention Study. Ethn Dis. 2003 Fall;13(4):438-55.

    PMID: 14632263BACKGROUND

  • Taylor HA Jr. Establishing a foundation for cardiovascular disease research in an African-American community--the Jackson Heart Study. Ethn Dis. 2003 Fall;13(4):411-3.

    PMID: 14632260BACKGROUND

  • Taylor HA Jr, Clark BL, Garrison RJ, Andrew ME, Han H, Fox ER, Arnett DK, Samdarshi T, Jones DW. Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans. Am J Cardiol. 2005 Feb 1;95(3):401-4. doi: 10.1016/j.amjcard.2004.09.043.

    PMID: 15670554BACKGROUND

  • Carpenter MA, Crow R, Steffes M, Rock W, Heilbraun J, Evans G, Skelton T, Jensen R, Sarpong D. Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study. Am J Med Sci. 2004 Sep;328(3):131-44. doi: 10.1097/00000441-200409000-00001.

    PMID: 15367870BACKGROUND

  • Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Mentz RJ, Bertoni AG. Dysglycemia and incident heart failure among blacks: The jackson heart study. Am Heart J. 2022 Mar;245:1-9. doi: 10.1016/j.ahj.2021.11.003. Epub 2021 Nov 19.

    PMID: 34808103DERIVED

  • Rao VN, Bush CG, Mongraw-Chaffin M, Hall ME, Clark D 3rd, Fudim M, Correa A, Hammill BG, O'Brien E, Min YI, Mentz RJ. Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study. J Am Heart Assoc. 2021 Jul 20;10(14):e020920. doi: 10.1161/JAHA.121.020920. Epub 2021 Jul 9.

    PMID: 34238024DERIVED

  • Rosen DM, Kundel V, Rueschman M, Kaplan R, Guo N, Wilson JG, Min YI, Redline S, Shah N. Self-reported snoring and incident cardiovascular disease events: results from the Jackson Heart Study. Sleep Breath. 2019 Sep;23(3):777-784. doi: 10.1007/s11325-018-01776-1. Epub 2019 Feb 13.

    PMID: 30756321DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

Serum, plasma, urine, DNA

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesAtherosclerosisCoronary DiseaseHypertensionCerebrovascular DisordersHeart FailureStrokeDiabetes MellitusRenal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial IschemiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesRenal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Wendy White, PhD

    Tougaloo College JHS UTEC

    PRINCIPAL INVESTIGATOR

  • Marinelle Payton, MD, PhD

    Jackson State University JHS GTEC

    PRINCIPAL INVESTIGATOR

  • April P Carson, PhD

    UMMC JHS CC and FC

    PRINCIPAL INVESTIGATOR

  • Victor Sutton, PhD

    Mississippi State Department of Health JHS CEC

    PRINCIPAL INVESTIGATOR

  • Jennifer Reneker, PhD

    UMMC JHS GTEC

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 19, 2000

Primary Completion

August 12, 2025

Study Completion

August 12, 2025

Last Updated

July 9, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will share

The JHS adheres to NIH and NHLBI policies for data sharing of epidemiologic studies. Data from each cycle of an examination or follow-up component are prepared by the JHS Coordinating Center and sent to the NHLBI PO for distribution as a data set after the completion of each examination or two years after the baseline, follow-up, genetic, ancillary study, or other data set is finalized within the study for analysis for use in publication. De-identified data from Exams 1, 2 and 3 of the JHS are available and shared commonly through the JHS processes for presentation and publication and ancillary studies. Public datasets for Exam 1, Exam 2, and Exam 3 have been provided to BioLINCC and dbGaP.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
Data are currently available for exams 1, 2 and 3 and for cardiovascular events through 12/31/2016 and mortality through 12/31/2019. Data will be available indefinitely.
Access Criteria
Data can accessed from JHS with approved manuscript proposals and from dbGaP and BIOLINCC.
More information

Locations

US(1)