NCT00005475

Brief Summary

To extend follow-up of a birth cohort of asthmatic children through adolescence and on to adulthood. .

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Aug 1996

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 1996

Completed
3.8 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
6.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2006

Completed
Last Updated

July 29, 2016

Status Verified

May 1, 2009

Enrollment Period

9.9 years

First QC Date

May 25, 2000

Last Update Submit

July 28, 2016

Conditions

AsthmaLung Diseases

Eligibility Criteria

AgeUp to 22 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (36)

  • Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, von Mutius E, Martinez FD. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol. 2000 Mar;105(3):506-13. doi: 10.1067/mai.2000.104940.

    PMID: 10719301BACKGROUND

  • Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet. 1999 Sep;354 Suppl 2:SII12-5. doi: 10.1016/s0140-6736(99)90437-3. No abstract available.

    PMID: 10507253BACKGROUND

  • Wright AL, Sherrill D, Holberg CJ, Halonen M, Martinez FD. Breast-feeding, maternal IgE, and total serum IgE in childhood. J Allergy Clin Immunol. 1999 Sep;104(3 Pt 1):589-94. doi: 10.1016/s0091-6749(99)70328-3.

    PMID: 10482832BACKGROUND

  • Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, Wright AL, Martinez FD. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999 Aug 14;354(9178):541-5. doi: 10.1016/S0140-6736(98)10321-5.

    PMID: 10470697BACKGROUND

  • Halonen M, Stern DA, Lohman C, Wright AL, Brown MA, Martinez FD. Two subphenotypes of childhood asthma that differ in maternal and paternal influences on asthma risk. Am J Respir Crit Care Med. 1999 Aug;160(2):564-70. doi: 10.1164/ajrccm.160.2.9809038.

    PMID: 10430729BACKGROUND

  • Sherrill DL, Stein R, Halonen M, Holberg CJ, Wright A, Martinez FD. Total serum IgE and its association with asthma symptoms and allergic sensitization among children. J Allergy Clin Immunol. 1999 Jul;104(1):28-36. doi: 10.1016/s0091-6749(99)70110-7.

    PMID: 10400836BACKGROUND

  • Castro-Rodriguez JA, Holberg CJ, Wright AL, Halonen M, Taussig LM, Morgan WJ, Martinez FD. Association of radiologically ascertained pneumonia before age 3 yr with asthmalike symptoms and pulmonary function during childhood: a prospective study. Am J Respir Crit Care Med. 1999 Jun;159(6):1891-7. doi: 10.1164/ajrccm.159.6.9811035.

    PMID: 10351936BACKGROUND

  • Martinez FD. Gene by environment interactions in the development of asthma. Clin Exp Allergy. 1998 Nov;28 Suppl 5:21-5; discussion 26-8. doi: 10.1046/j.1365-2222.1998.028s5021.x.

    PMID: 9988443BACKGROUND

  • Martinez FD, Stern DA, Wright AL, Taussig LM, Halonen M. Differential immune responses to acute lower respiratory illness in early life and subsequent development of persistent wheezing and asthma. J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):915-20. doi: 10.1016/s0091-6749(98)70328-8.

    PMID: 9847431BACKGROUND

  • Martinez FD, Solomon S, Holberg CJ, Graves PE, Baldini M, Erickson RP. Linkage of circulating eosinophils to markers on chromosome 5q. Am J Respir Crit Care Med. 1998 Dec;158(6):1739-44. doi: 10.1164/ajrccm.158.6.9712040.

    PMID: 9847261BACKGROUND

  • Stein RT, Holberg CJ, Morgan WJ, Wright AL, Lombardi E, Taussig L, Martinez FD. Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood. Thorax. 1997 Nov;52(11):946-52. doi: 10.1136/thx.52.11.946.

    PMID: 9487341BACKGROUND

  • Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest. 1997 Dec 15;100(12):3184-8. doi: 10.1172/JCI119874.

    PMID: 9399966BACKGROUND

  • Lombardi E, Morgan WJ, Wright AL, Stein RT, Holberg CJ, Martinez FD. Cold air challenge at age 6 and subsequent incidence of asthma. A longitudinal study. Am J Respir Crit Care Med. 1997 Dec;156(6):1863-9. doi: 10.1164/ajrccm.156.6.9612066.

    PMID: 9412567BACKGROUND

  • Wright AL, Holberg CJ, Taussig LM, Martinez FD. Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Thorax. 2001 Mar;56(3):192-7. doi: 10.1136/thorax.56.3.192.

    PMID: 11182011BACKGROUND

  • Wright AL, Holberg CJ, Taussig LM, Martinez F. Maternal asthma status alters relation of infant feeding to asthma in childhood. Adv Exp Med Biol. 2000;478:131-7. doi: 10.1007/0-306-46830-1_11.

    PMID: 11065066BACKGROUND

  • Martinez FD. Context dependency of markers of disease. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 2):S56-7. doi: 10.1164/ajrccm.162.supplement_1.maic-15. No abstract available.

    PMID: 10934136BACKGROUND

  • Vercelli D, Baldini M, Stern D, Lohman IC, Halonen M, Martinez F. CD14: a bridge between innate immunity and adaptive IgE responses. J Endotoxin Res. 2001;7(1):45-8.

    PMID: 11521081BACKGROUND

  • Martinez FD. Links between pediatric and adult asthma. J Allergy Clin Immunol. 2001 May;107(5 Suppl):S449-55. doi: 10.1067/mai.2001.114993.

    PMID: 11344374BACKGROUND

  • Karakoc F, Remes ST, Martinez FD, Wright AL. The association between persistent eosinophilia and asthma in childhood is independent of atopic status. Clin Exp Allergy. 2002 Jan;32(1):51-6. doi: 10.1046/j.0022-0477.2001.01273.x.

    PMID: 12002737BACKGROUND

  • Holberg CJ, Halonen M, Solomon S, Graves PE, Baldini M, Erickson RP, Martinez FD. Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q. J Allergy Clin Immunol. 2001 Nov;108(5):772-80. doi: 10.1067/mai.2001.119158.

    PMID: 11692103BACKGROUND

  • Taussig LM, Wright AL, Holberg CJ, Halonen M, Morgan WJ, Martinez FD. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol. 2003 Apr;111(4):661-75; quiz 676. doi: 10.1067/mai.2003.162.

    PMID: 12704342BACKGROUND

  • Guerra S, Sherrill DL, Bobadilla A, Martinez FD, Barbee RA. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest. 2002 Oct;122(4):1256-63. doi: 10.1378/chest.122.4.1256.

    PMID: 12377850BACKGROUND

  • Ball TM, Holberg CJ, Martinez FD, Wright AL. Is there a common cold constitution? Ambul Pediatr. 2002 Jul-Aug;2(4):261-7. doi: 10.1367/1539-4409(2002)0022.0.co;2.

    PMID: 12135399BACKGROUND

  • Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol. 2002 Mar;109(3):419-25. doi: 10.1067/mai.2002.121701.

    PMID: 11897985BACKGROUND

  • Ball TM, Holberg CJ, Aldous MB, Martinez FD, Wright AL. Influence of attendance at day care on the common cold from birth through 13 years of age. Arch Pediatr Adolesc Med. 2002 Feb;156(2):121-6. doi: 10.1001/archpedi.156.2.121.

    PMID: 11814371BACKGROUND

  • Martinez FD. The coming-of-age of the hygiene hypothesis. Respir Res. 2001;2(3):129-32. doi: 10.1186/rr48. Epub 2001 Apr 2.

    PMID: 11686875BACKGROUND

  • Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol. 2001 Oct;108(4):509-15. doi: 10.1067/mai.2001.117797.

    PMID: 11590373BACKGROUND

  • Castro-Rodriguez JA, Stern DA, Halonen M, Wright AL, Holberg CJ, Taussig LM, Martinez FD. Relation between infantile colic and asthma/atopy: a prospective study in an unselected population. Pediatrics. 2001 Oct;108(4):878-82. doi: 10.1542/peds.108.4.878.

    PMID: 11581439BACKGROUND

  • Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Martinez FD. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med. 2001 May;163(6):1344-9. doi: 10.1164/ajrccm.163.6.2006140.

    PMID: 11371399BACKGROUND

  • Patino CM, Martinez FD. Interactions between genes and environment in the development of asthma. Allergy. 2001 Apr;56(4):279-86. doi: 10.1034/j.1398-9995.2001.00135.x. No abstract available.

    PMID: 11284793BACKGROUND

  • Castro-Rodriguez JA, Holberg CJ, Morgan WJ, Wright AL, Halonen M, Taussig LM, Martinez FD. Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a prospective study. Pediatrics. 2001 Mar;107(3):512-8. doi: 10.1542/peds.107.3.512.

    PMID: 11230591BACKGROUND

  • Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1403-6. doi: 10.1164/ajrccm.162.4.9912111.

    PMID: 11029352BACKGROUND

  • Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med. 2000 Aug 24;343(8):538-43. doi: 10.1056/NEJM200008243430803.

    PMID: 10954761BACKGROUND

  • Guerra S, Wright AL, Morgan WJ, Sherrill DL, Holberg CJ, Martinez FD. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med. 2004 Jul 1;170(1):78-85. doi: 10.1164/rccm.200309-1224OC. Epub 2004 Mar 17.

    PMID: 15028559BACKGROUND

  • Stern DA, Lohman IC, Wright AL, Taussig LM, Martinez FD, Halonen M. Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environment. Clin Exp Allergy. 2004 Oct;34(10):1563-669. doi: 10.1111/j.1365-2222.2004.02088.x.

    PMID: 15479271BACKGROUND

  • Crestani E, Guerra S, Wright AL, Halonen M, Martinez FD. Parental asthma as a risk factor for the development of early skin test sensitization in children. J Allergy Clin Immunol. 2004 Feb;113(2):284-90. doi: 10.1016/j.jaci.2003.11.009.

    PMID: 14767443BACKGROUND

MeSH Terms

Conditions

AsthmaLung Diseases

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Fernando Martinez

    University of Arizona

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

August 1, 1996

Primary Completion

July 1, 2006

Study Completion

July 1, 2006

Last Updated

July 29, 2016

Record last verified: 2009-05